48 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	POLE2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (518 aa)
	USP31	Ubiquitin specific peptidase 31; Belongs to the peptidase C19 family. (1346 aa)
	UBA52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	USP10	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (798 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa)
	PCLAF	PAF domain-containing protein. (111 aa)
	KXD1	KxDL motif containing 1. (176 aa)
	RFC2	Replication factor C subunit 2. (352 aa)
	POLK	DNA polymerase kappa. (905 aa)
	POLE	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2281 aa)
	ENSCHIP00000002654	Uncharacterized protein. (121 aa)
	ENSCHIP00000000668	Ubiquitin-like domain-containing protein. (103 aa)
	POLH	DNA polymerase eta. (733 aa)
	UBA7	Ubiquitin like modifier activating enzyme 7. (1000 aa)
	POLD4	Uncharacterized protein. (132 aa)
	ENSCHIP00000009163	Uncharacterized protein. (122 aa)
	ENSCHIP00000009219	Ubiquitin-like domain-containing protein. (108 aa)
	TRIM25	Tripartite motif containing 25. (633 aa)
	RCBTB2	RCC1 and BTB domain containing protein 2. (551 aa)
	RFC3	Replication factor C subunit 3. (356 aa)
	REV1	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1254 aa)
	RCBTB1	RCC1 and BTB domain containing protein 1. (531 aa)
	MEIOB	Meiosis specific with OB-fold. (467 aa)
	RPS27A	Ubiquitin-like domain-containing protein. (156 aa)
	USP43	Ubiquitin specific peptidase 43; Belongs to the peptidase C19 family. (1121 aa)
	UBE2L6	Ubiquitin conjugating enzyme E2 L6; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
	UBC	Ubiquitin C. (655 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	TRIM47	Tripartite motif containing 47. (642 aa)
	POLD2	DNA polymerase delta 2, accessory subunit. (469 aa)
	POLI	DNA polymerase iota. (751 aa)
	POLE3	CBFD_NFYB_HMF domain-containing protein. (147 aa)
	ENSCHIP00000022790	UCH domain-containing protein. (675 aa)
	RFC4	Replication factor C subunit 4. (364 aa)
	TRIM65	Tripartite motif containing 65. (511 aa)
	UBB	Ubiquitin B. (323 aa)
	LOC108638216	Uncharacterized protein. (629 aa)
	ATAD5	ATPase family AAA domain containing 5. (1894 aa)
	RFC5	Replication factor C subunit 5. (339 aa)
	ISG15	Interferon-stimulated protein 17/ubiquitin cross-reactive protein. (157 aa)
	POLD1	DNA polymerase. (1115 aa)
	RPA2	Replication protein A2. (270 aa)
	ENSCHIP00000021132	Ubiquitin-like domain-containing protein. (127 aa)
	RFC1	Replication factor C subunit 1. (1143 aa)
	RPA3	Uncharacterized protein. (121 aa)
	ENSCHIP00000027691	Ubiquitin-like domain-containing protein. (116 aa)
	POLD3	Uncharacterized protein. (464 aa)
	POLE4	DNA polymerase epsilon 4, accessory subunit. (131 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAD5	ENSCHIP00000002654	ENSCHIP00000016824	ENSCHIP00000002654	ATPase family AAA domain containing 5.	Uncharacterized protein.	0.446
ATAD5	ENSCHIP00000009163	ENSCHIP00000016824	ENSCHIP00000009163	ATPase family AAA domain containing 5.	Uncharacterized protein.	0.588
ATAD5	ENSCHIP00000021132	ENSCHIP00000016824	ENSCHIP00000021132	ATPase family AAA domain containing 5.	Ubiquitin-like domain-containing protein.	0.421
ATAD5	MEIOB	ENSCHIP00000016824	ENSCHIP00000011102	ATPase family AAA domain containing 5.	Meiosis specific with OB-fold.	0.710
ATAD5	PCLAF	ENSCHIP00000016824	ENSCHIP00000032859	ATPase family AAA domain containing 5.	PAF domain-containing protein.	0.436
ATAD5	PCNA	ENSCHIP00000016824	ENSCHIP00000015091	ATPase family AAA domain containing 5.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.953
ATAD5	POLD1	ENSCHIP00000016824	ENSCHIP00000019836	ATPase family AAA domain containing 5.	DNA polymerase.	0.748
ATAD5	POLD2	ENSCHIP00000016824	ENSCHIP00000005641	ATPase family AAA domain containing 5.	DNA polymerase delta 2, accessory subunit.	0.630
ATAD5	POLE	ENSCHIP00000016824	ENSCHIP00000003433	ATPase family AAA domain containing 5.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.824
ATAD5	POLE2	ENSCHIP00000016824	ENSCHIP00000028310	ATPase family AAA domain containing 5.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.779
ATAD5	POLE3	ENSCHIP00000016824	ENSCHIP00000022059	ATPase family AAA domain containing 5.	CBFD_NFYB_HMF domain-containing protein.	0.637
ATAD5	POLE4	ENSCHIP00000016824	ENSCHIP00000028280	ATPase family AAA domain containing 5.	DNA polymerase epsilon 4, accessory subunit.	0.677
ATAD5	POLH	ENSCHIP00000016824	ENSCHIP00000006491	ATPase family AAA domain containing 5.	DNA polymerase eta.	0.574
ATAD5	POLI	ENSCHIP00000016824	ENSCHIP00000021798	ATPase family AAA domain containing 5.	DNA polymerase iota.	0.514
ATAD5	POLK	ENSCHIP00000016824	ENSCHIP00000003884	ATPase family AAA domain containing 5.	DNA polymerase kappa.	0.597
ATAD5	REV1	ENSCHIP00000016824	ENSCHIP00000010141	ATPase family AAA domain containing 5.	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family.	0.615
ATAD5	RFC1	ENSCHIP00000016824	ENSCHIP00000021706	ATPase family AAA domain containing 5.	Replication factor C subunit 1.	0.728
ATAD5	RFC2	ENSCHIP00000016824	ENSCHIP00000004939	ATPase family AAA domain containing 5.	Replication factor C subunit 2.	0.969
ATAD5	RFC3	ENSCHIP00000016824	ENSCHIP00000010064	ATPase family AAA domain containing 5.	Replication factor C subunit 3.	0.975
ATAD5	RFC4	ENSCHIP00000016824	ENSCHIP00000023106	ATPase family AAA domain containing 5.	Replication factor C subunit 4.	0.988