STRINGSTRING
ENSCHIP00000000835 ENSCHIP00000000835 LOC102184017 LOC102184017 RCBTB1 RCBTB1 KDM4A KDM4A RBBP8 RBBP8 EXO1 EXO1 H2BC21 H2BC21 RMI1 RMI1 H2BE1 H2BE1 XRCC6 XRCC6 ENSCHIP00000010204 ENSCHIP00000010204 RFC3 RFC3 RCBTB2 RCBTB2 TDP1 TDP1 ENSCHIP00000009605 ENSCHIP00000009605 ENSCHIP00000009386 ENSCHIP00000009386 ENSCHIP00000009219 ENSCHIP00000009219 ENSCHIP00000009200 ENSCHIP00000009200 ENSCHIP00000009147 ENSCHIP00000009147 LOC102189098 LOC102189098 POLD4 POLD4 ENSCHIP00000008488 ENSCHIP00000008488 LOC102180587 LOC102180587 LOC102172689 LOC102172689 APBB1 APBB1 ENSCHIP00000007999 ENSCHIP00000007999 H2BC11 H2BC11 CNPPD1 CNPPD1 NBN NBN RECQL4 RECQL4 ENSCHIP00000007594 ENSCHIP00000007594 H2BC3 H2BC3 LOC102185323 LOC102185323 EYA2 EYA2 TIMELESS TIMELESS LOC106503503 LOC106503503 LOC108636047 LOC108636047 LOC106503502 LOC106503502 BLM BLM POLH POLH TP53BP1 TP53BP1 PALB2 PALB2 ENSCHIP00000006197 ENSCHIP00000006197 LOC108633414 LOC108633414 H2BC6 H2BC6 ENSCHIP00000005897 ENSCHIP00000005897 ENSCHIP00000005753 ENSCHIP00000005753 LOC102180845 LOC102180845 LOC102172954 LOC102172954 POLD2 POLD2 NSD2 NSD2 ENSCHIP00000005277 ENSCHIP00000005277 H2BU1 H2BU1 H2BC15 H2BC15 FEN1 FEN1 RFC2 RFC2 RAD52 RAD52 ENSCHIP00000004577 ENSCHIP00000004577 SUMO1 SUMO1 H2BC1 H2BC1 LOC102179187 LOC102179187 ENSCHIP00000004381 ENSCHIP00000004381 ENSCHIP00000004308 ENSCHIP00000004308 ENSCHIP00000004205 ENSCHIP00000004205 ENSCHIP00000004152 ENSCHIP00000004152 POLK POLK ENSCHIP00000003806 ENSCHIP00000003806 ENSCHIP00000003676 ENSCHIP00000003676 LOC102172226 LOC102172226 H2BC18 H2BC18 LOC102182181 LOC102182181 RNF8 RNF8 ENSCHIP00000003493 ENSCHIP00000003493 LOC102183280 LOC102183280 POLE POLE ENSCHIP00000003174 ENSCHIP00000003174 RAD50 RAD50 CDK2 CDK2 UBXN1 UBXN1 PPP4R2 PPP4R2 LOC102175243 LOC102175243 LOC102181912 LOC102181912 RNF169 RNF169 ENSCHIP00000002654 ENSCHIP00000002654 DNTT DNTT ENSCHIP00000001833 ENSCHIP00000001833 POLL POLL BABAM2 BABAM2 LOC102180307 LOC102180307 ENSCHIP00000001380 ENSCHIP00000001380 ENSCHIP00000001154 ENSCHIP00000001154 H2BC12 H2BC12 ENSCHIP00000000954 ENSCHIP00000000954 LIG4 LIG4 TIPIN TIPIN ENSCHIP00000000668 ENSCHIP00000000668 LOC106503984 LOC106503984 ENSCHIP00000000047 ENSCHIP00000000047 KXD1 KXD1 TOP3A TOP3A RAD9A RAD9A RAD51B RAD51B MDC1 MDC1 SLC23A3 SLC23A3 NHEJ1 NHEJ1 WRN WRN RAD51C RAD51C RAD1 RAD1 SLF1 SLF1 TDP2 TDP2 UBC UBC PIAS4 PIAS4 KAT5 KAT5 ENSCHIP00000014639 ENSCHIP00000014639 DCLRE1C DCLRE1C PCNA PCNA RAD9B RAD9B XRCC4 XRCC4 BRIP1 BRIP1 PARP3 PARP3 EME1 EME1 HERC2 HERC2 ENSCHIP00000015808 ENSCHIP00000015808 ABRAXAS1 ABRAXAS1 ATM ATM SIRT7 SIRT7 RFC5 RFC5 SLX4 SLX4 KDM4B KDM4B UBE2I UBE2I CCNA2 CCNA2 ENSCHIP00000018629 ENSCHIP00000018629 PARP1 PARP1 SPIDR SPIDR BRCC3 BRCC3 POLD1 POLD1 ENSCHIP00000020042 ENSCHIP00000020042 RPA2 RPA2 DNA2 DNA2 ENSCHIP00000021132 ENSCHIP00000021132 RAD51D RAD51D CDK3 CDK3 RFC1 RFC1 TDRD3 TDRD3 POLE3 POLE3 PAXIP1 PAXIP1 RIF1 RIF1 ENSCHIP00000022726 ENSCHIP00000022726 XRCC1 XRCC1 RAD17 RAD17 RFC4 RFC4 XRCC3 XRCC3 SLX1A SLX1A ENSCHIP00000023574 ENSCHIP00000023574 BRCA2 BRCA2 TMEM182 TMEM182 RMI2 RMI2 MRE11 MRE11 BARD1 BARD1 ABL1 ABL1 EYA4 EYA4 EXD2 EXD2 ATR ATR EYA1 EYA1 BAP1 BAP1 XRCC5 XRCC5 ENSCHIP00000025548 ENSCHIP00000025548 PPP4C PPP4C ERCC4 ERCC4 ENSCHIP00000026297 ENSCHIP00000026297 UBB UBB UIMC1 UIMC1 POLM POLM ENSCHIP00000027126 ENSCHIP00000027126 RNF168 RNF168 RPA3 RPA3 ENSCHIP00000027691 ENSCHIP00000027691 CHEK2 CHEK2 POLD3 POLD3 POLE4 POLE4 POLE2 POLE2 LIG3 LIG3 MUS81 MUS81 APBB2 APBB2 HUS1 HUS1 XRCC2 XRCC2 ATRIP ATRIP UBA52 UBA52 ENSCHIP00000033267 ENSCHIP00000033267 RAD51 RAD51 BRCA1 BRCA1 KPNA2 KPNA2 TOPBP1 TOPBP1 EYA3 EYA3 SUMO2 SUMO2 KPNA7 KPNA7 RPA1 RPA1 ENSCHIP00000031621 ENSCHIP00000031621 SIRT6 SIRT6 ENSCHIP00000031435 ENSCHIP00000031435 ENSCHIP00000031302 ENSCHIP00000031302 ERCC1 ERCC1 CHEK1 CHEK1 TP53 TP53 BABAM1 BABAM1 PPP5C PPP5C PARP2 PARP2 RAD51AP1 RAD51AP1 PRKDC PRKDC GEN1 GEN1 CCNA1 CCNA1 POLQ POLQ RPS27A RPS27A UBE2V2 UBE2V2 RHNO1 RHNO1 LOC102172676 LOC102172676 MEIOB MEIOB ENSCHIP00000011074 ENSCHIP00000011074
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSCHIP00000000835Reverse transcriptase domain-containing protein. (303 aa)
LOC102184017Histone H2B type 1. (126 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
KDM4AUncharacterized protein. (1067 aa)
RBBP8RB binding protein 8, endonuclease. (889 aa)
EXO1Exonuclease 1. (835 aa)
H2BC21Histone H2B; Belongs to the histone H2B family. (126 aa)
RMI1RecQ mediated genome instability 1. (624 aa)
H2BE1Histone H2B; Belongs to the histone H2B family. (122 aa)
XRCC6X-ray repair cross complementing 6. (607 aa)
ENSCHIP00000010204TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (275 aa)
RFC3Replication factor C subunit 3. (356 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (551 aa)
TDP1Tyrosyl-DNA phosphodiesterase 1. (612 aa)
ENSCHIP00000009605Uncharacterized protein. (61 aa)
ENSCHIP00000009386Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (102 aa)
ENSCHIP00000009219Ubiquitin-like domain-containing protein. (108 aa)
ENSCHIP00000009200annotation not available (103 aa)
ENSCHIP00000009147annotation not available (103 aa)
LOC102189098MPN domain-containing protein. (291 aa)
POLD4Uncharacterized protein. (132 aa)
ENSCHIP00000008488annotation not available (103 aa)
LOC102180587Histone H2B type 1. (126 aa)
LOC102172689Importin subunit alpha; Functions in nuclear protein import. (529 aa)
APBB1Amyloid beta precursor protein binding family B member 1. (707 aa)
ENSCHIP00000007999Uncharacterized protein. (233 aa)
H2BC11Histone H2B; Belongs to the histone H2B family. (126 aa)
CNPPD1Cyclin Pas1/PHO80 domain containing 1. (411 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa)
RECQL4RecQ like helicase 4. (1176 aa)
ENSCHIP00000007594Ubiquitin carboxyl-terminal hydrolase. (721 aa)
H2BC3Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC102185323Histone H2B type 1. (126 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (552 aa)
TIMELESSTimeless circadian regulator. (1206 aa)
LOC106503503Histone H4. (103 aa)
LOC108636047Histone H4. (103 aa)
LOC106503502Histone H4. (103 aa)
BLMBLM RecQ like helicase. (1429 aa)
POLHDNA polymerase eta. (733 aa)
TP53BP1Tumor protein p53 binding protein 1. (1966 aa)
PALB2Partner and localizer of BRCA2. (1194 aa)
ENSCHIP00000006197Reverse transcriptase domain-containing protein. (851 aa)
LOC108633414Histone H2B type 1. (126 aa)
H2BC6Histone H2B type 1. (126 aa)
ENSCHIP00000005897Reverse transcriptase domain-containing protein. (269 aa)
ENSCHIP00000005753annotation not available (103 aa)
LOC102180845Histone H2B type 1. (126 aa)
LOC102172954Histone H4. (103 aa)
POLD2DNA polymerase delta 2, accessory subunit. (469 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1365 aa)
ENSCHIP00000005277annotation not available (103 aa)
H2BU1Histone H2B; Belongs to the histone H2B family. (126 aa)
H2BC15Histone H2B; Belongs to the histone H2B family. (126 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
RFC2Replication factor C subunit 2. (352 aa)
RAD52RAD52 homolog, DNA repair protein. (416 aa)
ENSCHIP00000004577Reverse transcriptase domain-containing protein. (738 aa)
SUMO1Small ubiquitin-related modifier. (101 aa)
H2BC1Histone H2B; Belongs to the histone H2B family. (127 aa)
LOC102179187Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSCHIP00000004381Reverse transcriptase domain-containing protein. (960 aa)
ENSCHIP00000004308annotation not available (103 aa)
ENSCHIP00000004205Reverse transcriptase domain-containing protein. (997 aa)
ENSCHIP00000004152annotation not available (103 aa)
POLKDNA polymerase kappa. (905 aa)
ENSCHIP00000003806Reverse transcriptase domain-containing protein. (310 aa)
ENSCHIP00000003676RECA_2 domain-containing protein. (278 aa)
LOC102172226Histone domain-containing protein; Belongs to the histone H2B family. (126 aa)
H2BC18Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC102182181Histone H2B type 1. (126 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (504 aa)
ENSCHIP00000003493MPN domain-containing protein. (262 aa)
LOC102183280Histone H2B type 1. (126 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2281 aa)
ENSCHIP00000003174Endo/exonuclease/phosphatase domain-containing protein. (426 aa)
RAD50Zinc-hook domain-containing protein. (1332 aa)
CDK2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (346 aa)
UBXN1UBX domain protein 1. (297 aa)
PPP4R2Protein phosphatase 4 regulatory subunit 2. (412 aa)
LOC102175243Histone domain-containing protein; Belongs to the histone H2B family. (122 aa)
LOC102181912Histone H2B; Belongs to the histone H2B family. (126 aa)
RNF169Ring finger protein 169. (708 aa)
ENSCHIP00000002654Uncharacterized protein. (121 aa)
DNTTDNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (501 aa)
ENSCHIP00000001833Reverse transcriptase domain-containing protein. (304 aa)
POLLDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (594 aa)
BABAM2BRISC and BRCA1 A complex member 2. (383 aa)
LOC102180307Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
ENSCHIP00000001380Reverse transcriptase domain-containing protein. (704 aa)
ENSCHIP00000001154Reverse transcriptase domain-containing protein. (730 aa)
H2BC12Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSCHIP00000000954Reverse transcriptase domain-containing protein. (679 aa)
LIG4DNA ligase. (911 aa)
TIPINTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (289 aa)
ENSCHIP00000000668Ubiquitin-like domain-containing protein. (103 aa)
LOC106503984Uncharacterized protein. (292 aa)
ENSCHIP00000000047RING-type domain-containing protein. (101 aa)
KXD1KxDL motif containing 1. (176 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1002 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (395 aa)
RAD51BRAD51 paralog B. (270 aa)
MDC1Mediator of DNA damage checkpoint 1. (1914 aa)
SLC23A3Solute carrier family 23 member 3. (585 aa)
NHEJ1Non-homologous end joining factor 1. (299 aa)
WRNWRN RecQ like helicase. (1405 aa)
RAD51CRAD51 paralog C. (371 aa)
RAD1Uncharacterized protein. (279 aa)
SLF1SMC5-SMC6 complex localization factor 1. (1056 aa)
TDP2Endo/exonuclease/phosphatase domain-containing protein. (330 aa)
UBCUbiquitin C. (655 aa)
PIAS4Protein inhibitor of activated STAT 4. (513 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa)
ENSCHIP00000014639Uncharacterized protein. (93 aa)
DCLRE1CDNA cross-link repair 1C. (710 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (428 aa)
XRCC4X-ray repair cross complementing 4. (332 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1217 aa)
PARP3Poly [ADP-ribose] polymerase. (525 aa)
EME1Essential meiotic structure-specific endonuclease 1. (580 aa)
HERC2HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4836 aa)
ENSCHIP00000015808BRCT domain-containing protein. (262 aa)
ABRAXAS1Abraxas 1, BRCA1 A complex subunit. (410 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3058 aa)
SIRT7Sirtuin 7. (405 aa)
RFC5Replication factor C subunit 5. (339 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1752 aa)
KDM4BLysine demethylase 4B. (1070 aa)
UBE2IUbiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (430 aa)
ENSCHIP00000018629Rad60-SLD domain-containing protein. (90 aa)
PARP1Poly [ADP-ribose] polymerase. (1020 aa)
SPIDRScaffold protein involved in DNA repair. (916 aa)
BRCC3MPN domain-containing protein. (288 aa)
POLD1DNA polymerase. (1115 aa)
ENSCHIP00000020042MPN domain-containing protein. (245 aa)
RPA2Replication protein A2. (270 aa)
DNA2DNA replication helicase/nuclease 2. (1062 aa)
ENSCHIP00000021132Ubiquitin-like domain-containing protein. (127 aa)
RAD51DDNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (338 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa)
RFC1Replication factor C subunit 1. (1143 aa)
TDRD3Tudor domain containing 3. (762 aa)
POLE3CBFD_NFYB_HMF domain-containing protein. (147 aa)
PAXIP1PAX interacting protein 1. (1006 aa)
RIF1Replication timing regulatory factor 1. (2486 aa)
ENSCHIP00000022726Uncharacterized protein. (88 aa)
XRCC1X-ray repair cross complementing 1. (632 aa)
RAD17RAD17 checkpoint clamp loader component. (709 aa)
RFC4Replication factor C subunit 4. (364 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (341 aa)
SLX1AStructure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (267 aa)
ENSCHIP00000023574Uncharacterized protein. (61 aa)
BRCA2BRCA2 DNA repair associated. (3405 aa)
TMEM182Transmembrane protein 182. (229 aa)
RMI2Uncharacterized protein. (161 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (724 aa)
BARD1BRCA1 associated RING domain 1. (775 aa)
ABL1Tyrosine-protein kinase. (1151 aa)
EYA4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (639 aa)
EXD2Exonuclease 3'-5' domain containing 2. (642 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (618 aa)
BAP1Ubiquitin carboxyl-terminal hydrolase. (729 aa)
XRCC5X-ray repair cross complementing 5. (736 aa)
ENSCHIP00000025548Uncharacterized protein. (51 aa)
PPP4CSerine/threonine-protein phosphatase. (307 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
ENSCHIP00000026297Histone domain-containing protein; Belongs to the histone H2B family. (112 aa)
UBBUbiquitin B. (323 aa)
UIMC1Ubiquitin interaction motif containing 1. (795 aa)
POLMDNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (488 aa)
ENSCHIP00000027126UBIQUITIN_CONJUGAT_2 domain-containing protein. (132 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (573 aa)
RPA3Uncharacterized protein. (121 aa)
ENSCHIP00000027691Ubiquitin-like domain-containing protein. (116 aa)
CHEK2Checkpoint kinase 2. (534 aa)
POLD3Uncharacterized protein. (464 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (131 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (518 aa)
LIG3DNA ligase. (1004 aa)
MUS81MUS81 structure-specific endonuclease subunit. (552 aa)
APBB2Amyloid beta precursor protein binding family B member 2. (755 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
XRCC2X-ray repair cross complementing 2. (280 aa)
ATRIPATR interacting protein. (791 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
ENSCHIP00000033267Reverse transcriptase domain-containing protein. (241 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1843 aa)
KPNA2Importin subunit alpha; Functions in nuclear protein import. (495 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1521 aa)
EYA3Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (573 aa)
SUMO2Small ubiquitin-related modifier. (95 aa)
KPNA7Importin subunit alpha; Functions in nuclear protein import. (522 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa)
ENSCHIP00000031621Uncharacterized protein. (159 aa)
SIRT6Sirtuin 6. (335 aa)
ENSCHIP00000031435Uncharacterized protein. (77 aa)
ENSCHIP00000031302UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (155 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (294 aa)
CHEK1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
BABAM1BRISC and BRCA1 A complex member 1. (332 aa)
PPP5CSerine/threonine-protein phosphatase. (528 aa)
PARP2Poly [ADP-ribose] polymerase. (533 aa)
RAD51AP1RAD51 associated protein 1. (326 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4117 aa)
GEN1GEN1 Holliday junction 5' flap endonuclease. (931 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (421 aa)
POLQDNA polymerase theta. (2587 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
UBE2V2Ubiquitin conjugating enzyme E2 V2. (148 aa)
RHNO1RAD9-HUS1-RAD1 interacting nuclear orphan 1. (241 aa)
LOC102172676Histone H2B type 2-E-like. (126 aa)
MEIOBMeiosis specific with OB-fold. (467 aa)
ENSCHIP00000011074annotation not available (103 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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