STRINGSTRING
ENSCHIP00000003493 ENSCHIP00000003493 LOC102183280 LOC102183280 ENSCHIP00000003174 ENSCHIP00000003174 RAD50 RAD50 LOC102175243 LOC102175243 LOC102181912 LOC102181912 RNF169 RNF169 DNTT DNTT ENSCHIP00000001833 ENSCHIP00000001833 POLL POLL BABAM2 BABAM2 LOC102180307 LOC102180307 ENSCHIP00000001380 ENSCHIP00000001380 ENSCHIP00000001154 ENSCHIP00000001154 H2BC12 H2BC12 ENSCHIP00000000954 ENSCHIP00000000954 LIG4 LIG4 ENSCHIP00000000835 ENSCHIP00000000835 LOC106503984 LOC106503984 ENSCHIP00000000047 ENSCHIP00000000047 ABRAXAS1 ABRAXAS1 ATM ATM BRCC3 BRCC3 ENSCHIP00000020042 ENSCHIP00000020042 PAXIP1 PAXIP1 RIF1 RIF1 TMEM182 TMEM182 MRE11 MRE11 BARD1 BARD1 XRCC5 XRCC5 ENSCHIP00000026297 ENSCHIP00000026297 UIMC1 UIMC1 LOC106503502 LOC106503502 TP53BP1 TP53BP1 ENSCHIP00000006197 ENSCHIP00000006197 LOC108633414 LOC108633414 H2BC6 H2BC6 ENSCHIP00000005897 ENSCHIP00000005897 ENSCHIP00000005753 ENSCHIP00000005753 LOC102180845 LOC102180845 LOC102172954 LOC102172954 NSD2 NSD2 ENSCHIP00000005277 ENSCHIP00000005277 H2BU1 H2BU1 H2BC15 H2BC15 ENSCHIP00000004577 ENSCHIP00000004577 H2BC1 H2BC1 LOC102185323 LOC102185323 LOC102184017 LOC102184017 H2BC3 H2BC3 NBN NBN CNPPD1 CNPPD1 H2BC11 H2BC11 LOC102180587 LOC102180587 ENSCHIP00000008488 ENSCHIP00000008488 LOC102189098 LOC102189098 ENSCHIP00000009147 ENSCHIP00000009147 ENSCHIP00000009200 ENSCHIP00000009200 ENSCHIP00000009386 ENSCHIP00000009386 ENSCHIP00000009605 ENSCHIP00000009605 TDP1 TDP1 H2BE1 H2BE1 H2BC21 H2BC21 LOC102172676 LOC102172676 ENSCHIP00000011074 ENSCHIP00000011074 XRCC6 XRCC6 POLM POLM ENSCHIP00000027126 ENSCHIP00000027126 RNF168 RNF168 BABAM1 BABAM1 LOC106503503 LOC106503503 ENSCHIP00000033267 ENSCHIP00000033267 BRCA1 BRCA1 LOC108636047 LOC108636047 UBE2V2 UBE2V2 PRKDC PRKDC MDC1 MDC1 SLC23A3 SLC23A3 NHEJ1 NHEJ1 TDP2 TDP2 PIAS4 PIAS4 KAT5 KAT5 DCLRE1C DCLRE1C XRCC4 XRCC4 HERC2 HERC2 ENSCHIP00000031302 ENSCHIP00000031302 ENSCHIP00000015808 ENSCHIP00000015808 LOC102179187 LOC102179187 ENSCHIP00000004381 ENSCHIP00000004381 ENSCHIP00000004308 ENSCHIP00000004308 ENSCHIP00000004205 ENSCHIP00000004205 ENSCHIP00000004152 ENSCHIP00000004152 ENSCHIP00000003806 ENSCHIP00000003806 LOC102172226 LOC102172226 H2BC18 H2BC18 LOC102182181 LOC102182181 RNF8 RNF8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSCHIP00000003493MPN domain-containing protein. (262 aa)
LOC102183280Histone H2B type 1. (126 aa)
ENSCHIP00000003174Endo/exonuclease/phosphatase domain-containing protein. (426 aa)
RAD50Zinc-hook domain-containing protein. (1332 aa)
LOC102175243Histone domain-containing protein; Belongs to the histone H2B family. (122 aa)
LOC102181912Histone H2B; Belongs to the histone H2B family. (126 aa)
RNF169Ring finger protein 169. (708 aa)
DNTTDNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (501 aa)
ENSCHIP00000001833Reverse transcriptase domain-containing protein. (304 aa)
POLLDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (594 aa)
BABAM2BRISC and BRCA1 A complex member 2. (383 aa)
LOC102180307Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
ENSCHIP00000001380Reverse transcriptase domain-containing protein. (704 aa)
ENSCHIP00000001154Reverse transcriptase domain-containing protein. (730 aa)
H2BC12Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSCHIP00000000954Reverse transcriptase domain-containing protein. (679 aa)
LIG4DNA ligase. (911 aa)
ENSCHIP00000000835Reverse transcriptase domain-containing protein. (303 aa)
LOC106503984Uncharacterized protein. (292 aa)
ENSCHIP00000000047RING-type domain-containing protein. (101 aa)
ABRAXAS1Abraxas 1, BRCA1 A complex subunit. (410 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3058 aa)
BRCC3MPN domain-containing protein. (288 aa)
ENSCHIP00000020042MPN domain-containing protein. (245 aa)
PAXIP1PAX interacting protein 1. (1006 aa)
RIF1Replication timing regulatory factor 1. (2486 aa)
TMEM182Transmembrane protein 182. (229 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (724 aa)
BARD1BRCA1 associated RING domain 1. (775 aa)
XRCC5X-ray repair cross complementing 5. (736 aa)
ENSCHIP00000026297Histone domain-containing protein; Belongs to the histone H2B family. (112 aa)
UIMC1Ubiquitin interaction motif containing 1. (795 aa)
LOC106503502Histone H4. (103 aa)
TP53BP1Tumor protein p53 binding protein 1. (1966 aa)
ENSCHIP00000006197Reverse transcriptase domain-containing protein. (851 aa)
LOC108633414Histone H2B type 1. (126 aa)
H2BC6Histone H2B type 1. (126 aa)
ENSCHIP00000005897Reverse transcriptase domain-containing protein. (269 aa)
ENSCHIP00000005753annotation not available (103 aa)
LOC102180845Histone H2B type 1. (126 aa)
LOC102172954Histone H4. (103 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1365 aa)
ENSCHIP00000005277annotation not available (103 aa)
H2BU1Histone H2B; Belongs to the histone H2B family. (126 aa)
H2BC15Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSCHIP00000004577Reverse transcriptase domain-containing protein. (738 aa)
H2BC1Histone H2B; Belongs to the histone H2B family. (127 aa)
LOC102185323Histone H2B type 1. (126 aa)
LOC102184017Histone H2B type 1. (126 aa)
H2BC3Histone H2B; Belongs to the histone H2B family. (126 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa)
CNPPD1Cyclin Pas1/PHO80 domain containing 1. (411 aa)
H2BC11Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC102180587Histone H2B type 1. (126 aa)
ENSCHIP00000008488annotation not available (103 aa)
LOC102189098MPN domain-containing protein. (291 aa)
ENSCHIP00000009147annotation not available (103 aa)
ENSCHIP00000009200annotation not available (103 aa)
ENSCHIP00000009386Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (102 aa)
ENSCHIP00000009605Uncharacterized protein. (61 aa)
TDP1Tyrosyl-DNA phosphodiesterase 1. (612 aa)
H2BE1Histone H2B; Belongs to the histone H2B family. (122 aa)
H2BC21Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC102172676Histone H2B type 2-E-like. (126 aa)
ENSCHIP00000011074annotation not available (103 aa)
XRCC6X-ray repair cross complementing 6. (607 aa)
POLMDNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (488 aa)
ENSCHIP00000027126UBIQUITIN_CONJUGAT_2 domain-containing protein. (132 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (573 aa)
BABAM1BRISC and BRCA1 A complex member 1. (332 aa)
LOC106503503Histone H4. (103 aa)
ENSCHIP00000033267Reverse transcriptase domain-containing protein. (241 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1843 aa)
LOC108636047Histone H4. (103 aa)
UBE2V2Ubiquitin conjugating enzyme E2 V2. (148 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4117 aa)
MDC1Mediator of DNA damage checkpoint 1. (1914 aa)
SLC23A3Solute carrier family 23 member 3. (585 aa)
NHEJ1Non-homologous end joining factor 1. (299 aa)
TDP2Endo/exonuclease/phosphatase domain-containing protein. (330 aa)
PIAS4Protein inhibitor of activated STAT 4. (513 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa)
DCLRE1CDNA cross-link repair 1C. (710 aa)
XRCC4X-ray repair cross complementing 4. (332 aa)
HERC2HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4836 aa)
ENSCHIP00000031302UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (155 aa)
ENSCHIP00000015808BRCT domain-containing protein. (262 aa)
LOC102179187Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSCHIP00000004381Reverse transcriptase domain-containing protein. (960 aa)
ENSCHIP00000004308annotation not available (103 aa)
ENSCHIP00000004205Reverse transcriptase domain-containing protein. (997 aa)
ENSCHIP00000004152annotation not available (103 aa)
ENSCHIP00000003806Reverse transcriptase domain-containing protein. (310 aa)
LOC102172226Histone domain-containing protein; Belongs to the histone H2B family. (126 aa)
H2BC18Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC102182181Histone H2B type 1. (126 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (504 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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