STRINGSTRING
SUMO2 SUMO2 TOPBP1 TOPBP1 BRCA1 BRCA1 ENSCHIP00000033267 ENSCHIP00000033267 H2BC6 H2BC6 LOC108633414 LOC108633414 ENSCHIP00000006197 ENSCHIP00000006197 TP53BP1 TP53BP1 BLM BLM TIMELESS TIMELESS LOC102185323 LOC102185323 H2BC3 H2BC3 RECQL4 RECQL4 NBN NBN H2BC11 H2BC11 ENSCHIP00000007999 ENSCHIP00000007999 LOC102180587 LOC102180587 ENSCHIP00000009605 ENSCHIP00000009605 RCBTB2 RCBTB2 RFC3 RFC3 ENSCHIP00000010204 ENSCHIP00000010204 H2BE1 H2BE1 RMI1 RMI1 H2BC21 H2BC21 EXO1 EXO1 RBBP8 RBBP8 RCBTB1 RCBTB1 LOC102184017 LOC102184017 LOC102172676 LOC102172676 RHNO1 RHNO1 CCNA1 CCNA1 TOP3A TOP3A RAD9A RAD9A MDC1 MDC1 WRN WRN RAD1 RAD1 PIAS4 PIAS4 KAT5 KAT5 RAD9B RAD9B BRIP1 BRIP1 HERC2 HERC2 ENSCHIP00000015808 ENSCHIP00000015808 ABRAXAS1 ABRAXAS1 ATM ATM RFC5 RFC5 UBE2I UBE2I CCNA2 CCNA2 ENSCHIP00000018629 ENSCHIP00000018629 BRCC3 BRCC3 RPA2 RPA2 DNA2 DNA2 CDK3 CDK3 RAD17 RAD17 RFC4 RFC4 RMI2 RMI2 MRE11 MRE11 BARD1 BARD1 ATR ATR PPP4C PPP4C ENSCHIP00000026297 ENSCHIP00000026297 UIMC1 UIMC1 ENSCHIP00000027126 ENSCHIP00000027126 RNF168 RNF168 RPA3 RPA3 HUS1 HUS1 ATRIP ATRIP BABAM1 BABAM1 CHEK1 CHEK1 ENSCHIP00000031302 ENSCHIP00000031302 ENSCHIP00000031435 ENSCHIP00000031435 SIRT6 SIRT6 ENSCHIP00000031621 ENSCHIP00000031621 RPA1 RPA1 ENSCHIP00000000047 ENSCHIP00000000047 TIPIN TIPIN ENSCHIP00000000835 ENSCHIP00000000835 ENSCHIP00000000954 ENSCHIP00000000954 H2BC12 H2BC12 ENSCHIP00000001154 ENSCHIP00000001154 ENSCHIP00000001380 ENSCHIP00000001380 BABAM2 BABAM2 ENSCHIP00000001833 ENSCHIP00000001833 ENSCHIP00000002654 ENSCHIP00000002654 RNF169 RNF169 LOC102181912 LOC102181912 LOC102175243 LOC102175243 PPP4R2 PPP4R2 CDK2 CDK2 RAD50 RAD50 ENSCHIP00000003174 ENSCHIP00000003174 LOC102183280 LOC102183280 RNF8 RNF8 LOC102182181 LOC102182181 H2BC18 H2BC18 LOC102172226 LOC102172226 ENSCHIP00000003806 ENSCHIP00000003806 ENSCHIP00000004205 ENSCHIP00000004205 ENSCHIP00000004308 ENSCHIP00000004308 ENSCHIP00000004381 ENSCHIP00000004381 LOC102179187 LOC102179187 ENSCHIP00000004577 ENSCHIP00000004577 RFC2 RFC2 H2BC15 H2BC15 H2BU1 H2BU1 NSD2 NSD2 LOC102180845 LOC102180845 ENSCHIP00000005897 ENSCHIP00000005897
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SUMO2Small ubiquitin-related modifier. (95 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1521 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1843 aa)
ENSCHIP00000033267Reverse transcriptase domain-containing protein. (241 aa)
H2BC6Histone H2B type 1. (126 aa)
LOC108633414Histone H2B type 1. (126 aa)
ENSCHIP00000006197Reverse transcriptase domain-containing protein. (851 aa)
TP53BP1Tumor protein p53 binding protein 1. (1966 aa)
BLMBLM RecQ like helicase. (1429 aa)
TIMELESSTimeless circadian regulator. (1206 aa)
LOC102185323Histone H2B type 1. (126 aa)
H2BC3Histone H2B; Belongs to the histone H2B family. (126 aa)
RECQL4RecQ like helicase 4. (1176 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa)
H2BC11Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSCHIP00000007999Uncharacterized protein. (233 aa)
LOC102180587Histone H2B type 1. (126 aa)
ENSCHIP00000009605Uncharacterized protein. (61 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (551 aa)
RFC3Replication factor C subunit 3. (356 aa)
ENSCHIP00000010204TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (275 aa)
H2BE1Histone H2B; Belongs to the histone H2B family. (122 aa)
RMI1RecQ mediated genome instability 1. (624 aa)
H2BC21Histone H2B; Belongs to the histone H2B family. (126 aa)
EXO1Exonuclease 1. (835 aa)
RBBP8RB binding protein 8, endonuclease. (889 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
LOC102184017Histone H2B type 1. (126 aa)
LOC102172676Histone H2B type 2-E-like. (126 aa)
RHNO1RAD9-HUS1-RAD1 interacting nuclear orphan 1. (241 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (421 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1002 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (395 aa)
MDC1Mediator of DNA damage checkpoint 1. (1914 aa)
WRNWRN RecQ like helicase. (1405 aa)
RAD1Uncharacterized protein. (279 aa)
PIAS4Protein inhibitor of activated STAT 4. (513 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (428 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1217 aa)
HERC2HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4836 aa)
ENSCHIP00000015808BRCT domain-containing protein. (262 aa)
ABRAXAS1Abraxas 1, BRCA1 A complex subunit. (410 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3058 aa)
RFC5Replication factor C subunit 5. (339 aa)
UBE2IUbiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (430 aa)
ENSCHIP00000018629Rad60-SLD domain-containing protein. (90 aa)
BRCC3MPN domain-containing protein. (288 aa)
RPA2Replication protein A2. (270 aa)
DNA2DNA replication helicase/nuclease 2. (1062 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa)
RAD17RAD17 checkpoint clamp loader component. (709 aa)
RFC4Replication factor C subunit 4. (364 aa)
RMI2Uncharacterized protein. (161 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (724 aa)
BARD1BRCA1 associated RING domain 1. (775 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
PPP4CSerine/threonine-protein phosphatase. (307 aa)
ENSCHIP00000026297Histone domain-containing protein; Belongs to the histone H2B family. (112 aa)
UIMC1Ubiquitin interaction motif containing 1. (795 aa)
ENSCHIP00000027126UBIQUITIN_CONJUGAT_2 domain-containing protein. (132 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (573 aa)
RPA3Uncharacterized protein. (121 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
ATRIPATR interacting protein. (791 aa)
BABAM1BRISC and BRCA1 A complex member 1. (332 aa)
CHEK1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
ENSCHIP00000031302UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (155 aa)
ENSCHIP00000031435Uncharacterized protein. (77 aa)
SIRT6Sirtuin 6. (335 aa)
ENSCHIP00000031621Uncharacterized protein. (159 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa)
ENSCHIP00000000047RING-type domain-containing protein. (101 aa)
TIPINTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (289 aa)
ENSCHIP00000000835Reverse transcriptase domain-containing protein. (303 aa)
ENSCHIP00000000954Reverse transcriptase domain-containing protein. (679 aa)
H2BC12Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSCHIP00000001154Reverse transcriptase domain-containing protein. (730 aa)
ENSCHIP00000001380Reverse transcriptase domain-containing protein. (704 aa)
BABAM2BRISC and BRCA1 A complex member 2. (383 aa)
ENSCHIP00000001833Reverse transcriptase domain-containing protein. (304 aa)
ENSCHIP00000002654Uncharacterized protein. (121 aa)
RNF169Ring finger protein 169. (708 aa)
LOC102181912Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC102175243Histone domain-containing protein; Belongs to the histone H2B family. (122 aa)
PPP4R2Protein phosphatase 4 regulatory subunit 2. (412 aa)
CDK2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (346 aa)
RAD50Zinc-hook domain-containing protein. (1332 aa)
ENSCHIP00000003174Endo/exonuclease/phosphatase domain-containing protein. (426 aa)
LOC102183280Histone H2B type 1. (126 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (504 aa)
LOC102182181Histone H2B type 1. (126 aa)
H2BC18Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC102172226Histone domain-containing protein; Belongs to the histone H2B family. (126 aa)
ENSCHIP00000003806Reverse transcriptase domain-containing protein. (310 aa)
ENSCHIP00000004205Reverse transcriptase domain-containing protein. (997 aa)
ENSCHIP00000004308annotation not available (103 aa)
ENSCHIP00000004381Reverse transcriptase domain-containing protein. (960 aa)
LOC102179187Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSCHIP00000004577Reverse transcriptase domain-containing protein. (738 aa)
RFC2Replication factor C subunit 2. (352 aa)
H2BC15Histone H2B; Belongs to the histone H2B family. (126 aa)
H2BU1Histone H2B; Belongs to the histone H2B family. (126 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1365 aa)
LOC102180845Histone H2B type 1. (126 aa)
ENSCHIP00000005897Reverse transcriptase domain-containing protein. (269 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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