Your Input: | |||||
SUMO2 | Small ubiquitin-related modifier. (95 aa) | ||||
TOPBP1 | DNA topoisomerase II binding protein 1. (1521 aa) | ||||
BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1843 aa) | ||||
ENSCHIP00000033267 | Reverse transcriptase domain-containing protein. (241 aa) | ||||
H2BC6 | Histone H2B type 1. (126 aa) | ||||
LOC108633414 | Histone H2B type 1. (126 aa) | ||||
ENSCHIP00000006197 | Reverse transcriptase domain-containing protein. (851 aa) | ||||
TP53BP1 | Tumor protein p53 binding protein 1. (1966 aa) | ||||
BLM | BLM RecQ like helicase. (1429 aa) | ||||
TIMELESS | Timeless circadian regulator. (1206 aa) | ||||
LOC102185323 | Histone H2B type 1. (126 aa) | ||||
H2BC3 | Histone H2B; Belongs to the histone H2B family. (126 aa) | ||||
RECQL4 | RecQ like helicase 4. (1176 aa) | ||||
NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa) | ||||
H2BC11 | Histone H2B; Belongs to the histone H2B family. (126 aa) | ||||
ENSCHIP00000007999 | Uncharacterized protein. (233 aa) | ||||
LOC102180587 | Histone H2B type 1. (126 aa) | ||||
ENSCHIP00000009605 | Uncharacterized protein. (61 aa) | ||||
RCBTB2 | RCC1 and BTB domain containing protein 2. (551 aa) | ||||
RFC3 | Replication factor C subunit 3. (356 aa) | ||||
ENSCHIP00000010204 | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (275 aa) | ||||
H2BE1 | Histone H2B; Belongs to the histone H2B family. (122 aa) | ||||
RMI1 | RecQ mediated genome instability 1. (624 aa) | ||||
H2BC21 | Histone H2B; Belongs to the histone H2B family. (126 aa) | ||||
EXO1 | Exonuclease 1. (835 aa) | ||||
RBBP8 | RB binding protein 8, endonuclease. (889 aa) | ||||
RCBTB1 | RCC1 and BTB domain containing protein 1. (531 aa) | ||||
LOC102184017 | Histone H2B type 1. (126 aa) | ||||
LOC102172676 | Histone H2B type 2-E-like. (126 aa) | ||||
RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (241 aa) | ||||
CCNA1 | Cyclin A1; Belongs to the cyclin family. (421 aa) | ||||
TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1002 aa) | ||||
RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (395 aa) | ||||
MDC1 | Mediator of DNA damage checkpoint 1. (1914 aa) | ||||
WRN | WRN RecQ like helicase. (1405 aa) | ||||
RAD1 | Uncharacterized protein. (279 aa) | ||||
PIAS4 | Protein inhibitor of activated STAT 4. (513 aa) | ||||
KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa) | ||||
RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (428 aa) | ||||
BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (1217 aa) | ||||
HERC2 | HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4836 aa) | ||||
ENSCHIP00000015808 | BRCT domain-containing protein. (262 aa) | ||||
ABRAXAS1 | Abraxas 1, BRCA1 A complex subunit. (410 aa) | ||||
ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3058 aa) | ||||
RFC5 | Replication factor C subunit 5. (339 aa) | ||||
UBE2I | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (158 aa) | ||||
CCNA2 | Cyclin A2; Belongs to the cyclin family. (430 aa) | ||||
ENSCHIP00000018629 | Rad60-SLD domain-containing protein. (90 aa) | ||||
BRCC3 | MPN domain-containing protein. (288 aa) | ||||
RPA2 | Replication protein A2. (270 aa) | ||||
DNA2 | DNA replication helicase/nuclease 2. (1062 aa) | ||||
CDK3 | Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa) | ||||
RAD17 | RAD17 checkpoint clamp loader component. (709 aa) | ||||
RFC4 | Replication factor C subunit 4. (364 aa) | ||||
RMI2 | Uncharacterized protein. (161 aa) | ||||
MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (724 aa) | ||||
BARD1 | BRCA1 associated RING domain 1. (775 aa) | ||||
ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa) | ||||
PPP4C | Serine/threonine-protein phosphatase. (307 aa) | ||||
ENSCHIP00000026297 | Histone domain-containing protein; Belongs to the histone H2B family. (112 aa) | ||||
UIMC1 | Ubiquitin interaction motif containing 1. (795 aa) | ||||
ENSCHIP00000027126 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (132 aa) | ||||
RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (573 aa) | ||||
RPA3 | Uncharacterized protein. (121 aa) | ||||
HUS1 | Checkpoint protein; Belongs to the HUS1 family. (280 aa) | ||||
ATRIP | ATR interacting protein. (791 aa) | ||||
BABAM1 | BRISC and BRCA1 A complex member 1. (332 aa) | ||||
CHEK1 | Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa) | ||||
ENSCHIP00000031302 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (155 aa) | ||||
ENSCHIP00000031435 | Uncharacterized protein. (77 aa) | ||||
SIRT6 | Sirtuin 6. (335 aa) | ||||
ENSCHIP00000031621 | Uncharacterized protein. (159 aa) | ||||
RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa) | ||||
ENSCHIP00000000047 | RING-type domain-containing protein. (101 aa) | ||||
TIPIN | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (289 aa) | ||||
ENSCHIP00000000835 | Reverse transcriptase domain-containing protein. (303 aa) | ||||
ENSCHIP00000000954 | Reverse transcriptase domain-containing protein. (679 aa) | ||||
H2BC12 | Histone H2B; Belongs to the histone H2B family. (126 aa) | ||||
ENSCHIP00000001154 | Reverse transcriptase domain-containing protein. (730 aa) | ||||
ENSCHIP00000001380 | Reverse transcriptase domain-containing protein. (704 aa) | ||||
BABAM2 | BRISC and BRCA1 A complex member 2. (383 aa) | ||||
ENSCHIP00000001833 | Reverse transcriptase domain-containing protein. (304 aa) | ||||
ENSCHIP00000002654 | Uncharacterized protein. (121 aa) | ||||
RNF169 | Ring finger protein 169. (708 aa) | ||||
LOC102181912 | Histone H2B; Belongs to the histone H2B family. (126 aa) | ||||
LOC102175243 | Histone domain-containing protein; Belongs to the histone H2B family. (122 aa) | ||||
PPP4R2 | Protein phosphatase 4 regulatory subunit 2. (412 aa) | ||||
CDK2 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (346 aa) | ||||
RAD50 | Zinc-hook domain-containing protein. (1332 aa) | ||||
ENSCHIP00000003174 | Endo/exonuclease/phosphatase domain-containing protein. (426 aa) | ||||
LOC102183280 | Histone H2B type 1. (126 aa) | ||||
RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (504 aa) | ||||
LOC102182181 | Histone H2B type 1. (126 aa) | ||||
H2BC18 | Histone H2B; Belongs to the histone H2B family. (126 aa) | ||||
LOC102172226 | Histone domain-containing protein; Belongs to the histone H2B family. (126 aa) | ||||
ENSCHIP00000003806 | Reverse transcriptase domain-containing protein. (310 aa) | ||||
ENSCHIP00000004205 | Reverse transcriptase domain-containing protein. (997 aa) | ||||
ENSCHIP00000004308 | annotation not available (103 aa) | ||||
ENSCHIP00000004381 | Reverse transcriptase domain-containing protein. (960 aa) | ||||
LOC102179187 | Histone H2B; Belongs to the histone H2B family. (126 aa) | ||||
ENSCHIP00000004577 | Reverse transcriptase domain-containing protein. (738 aa) | ||||
RFC2 | Replication factor C subunit 2. (352 aa) | ||||
H2BC15 | Histone H2B; Belongs to the histone H2B family. (126 aa) | ||||
H2BU1 | Histone H2B; Belongs to the histone H2B family. (126 aa) | ||||
NSD2 | Nuclear receptor binding SET domain protein 2. (1365 aa) | ||||
LOC102180845 | Histone H2B type 1. (126 aa) | ||||
ENSCHIP00000005897 | Reverse transcriptase domain-containing protein. (269 aa) |