STRINGSTRING
PRIM1 PRIM1 RPA1 RPA1 LIG1 LIG1 PRIM2 PRIM2 POLD3 POLD3 RPA3 RPA3 POLA2 POLA2 DNA2 DNA2 RPA2 RPA2 POLD1 POLD1 POLA1 POLA1 PCNA PCNA MEIOB MEIOB POLD4 POLD4 POLD2 POLD2 FEN1 FEN1 ENSCHIP00000002654 ENSCHIP00000002654
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRIM1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (401 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa)
LIG1DNA ligase. (915 aa)
PRIM2Uncharacterized protein. (219 aa)
POLD3Uncharacterized protein. (464 aa)
RPA3Uncharacterized protein. (121 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (603 aa)
DNA2DNA replication helicase/nuclease 2. (1062 aa)
RPA2Replication protein A2. (270 aa)
POLD1DNA polymerase. (1115 aa)
POLA1DNA polymerase. (1468 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
MEIOBMeiosis specific with OB-fold. (467 aa)
POLD4Uncharacterized protein. (132 aa)
POLD2DNA polymerase delta 2, accessory subunit. (469 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
ENSCHIP00000002654Uncharacterized protein. (121 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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