29 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSCHIP00000002654	Uncharacterized protein. (121 aa)
	PRIM1	DNA primase; Belongs to the eukaryotic-type primase small subunit family. (401 aa)
	LIG1	DNA ligase. (915 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa)
	PRIM2	Uncharacterized protein. (219 aa)
	POLD3	Uncharacterized protein. (464 aa)
	RPA3	Uncharacterized protein. (121 aa)
	POLA2	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (603 aa)
	GINS3	GINS complex subunit 3. (216 aa)
	RFC4	Replication factor C subunit 4. (364 aa)
	RFC1	Replication factor C subunit 1. (1143 aa)
	DNA2	DNA replication helicase/nuclease 2. (1062 aa)
	RPA2	Replication protein A2. (270 aa)
	POLD1	DNA polymerase. (1115 aa)
	RFC5	Replication factor C subunit 5. (339 aa)
	ATAD5	ATPase family AAA domain containing 5. (1894 aa)
	POLA1	DNA polymerase. (1468 aa)
	GINS2	DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa)
	GINS4	DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	MEIOB	Meiosis specific with OB-fold. (467 aa)
	RCBTB1	RCC1 and BTB domain containing protein 1. (531 aa)
	RFC3	Replication factor C subunit 3. (356 aa)
	RCBTB2	RCC1 and BTB domain containing protein 2. (551 aa)
	POLD4	Uncharacterized protein. (132 aa)
	GINS1	GINS complex subunit 1. (196 aa)
	POLD2	DNA polymerase delta 2, accessory subunit. (469 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
	RFC2	Replication factor C subunit 2. (352 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAD5	DNA2	ENSCHIP00000016824	ENSCHIP00000020258	ATPase family AAA domain containing 5.	DNA replication helicase/nuclease 2.	0.829
ATAD5	ENSCHIP00000002654	ENSCHIP00000016824	ENSCHIP00000002654	ATPase family AAA domain containing 5.	Uncharacterized protein.	0.446
ATAD5	FEN1	ENSCHIP00000016824	ENSCHIP00000005017	ATPase family AAA domain containing 5.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.891
ATAD5	LIG1	ENSCHIP00000016824	ENSCHIP00000032333	ATPase family AAA domain containing 5.	DNA ligase.	0.766
ATAD5	MEIOB	ENSCHIP00000016824	ENSCHIP00000011102	ATPase family AAA domain containing 5.	Meiosis specific with OB-fold.	0.710
ATAD5	PCNA	ENSCHIP00000016824	ENSCHIP00000015091	ATPase family AAA domain containing 5.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.953
ATAD5	POLA1	ENSCHIP00000016824	ENSCHIP00000016749	ATPase family AAA domain containing 5.	DNA polymerase.	0.800
ATAD5	POLA2	ENSCHIP00000016824	ENSCHIP00000024367	ATPase family AAA domain containing 5.	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.	0.830
ATAD5	POLD1	ENSCHIP00000016824	ENSCHIP00000019836	ATPase family AAA domain containing 5.	DNA polymerase.	0.748
ATAD5	POLD2	ENSCHIP00000016824	ENSCHIP00000005641	ATPase family AAA domain containing 5.	DNA polymerase delta 2, accessory subunit.	0.630
ATAD5	PRIM1	ENSCHIP00000016824	ENSCHIP00000033299	ATPase family AAA domain containing 5.	DNA primase; Belongs to the eukaryotic-type primase small subunit family.	0.730
ATAD5	PRIM2	ENSCHIP00000016824	ENSCHIP00000031577	ATPase family AAA domain containing 5.	Uncharacterized protein.	0.776
ATAD5	RFC1	ENSCHIP00000016824	ENSCHIP00000021706	ATPase family AAA domain containing 5.	Replication factor C subunit 1.	0.728
ATAD5	RFC2	ENSCHIP00000016824	ENSCHIP00000004939	ATPase family AAA domain containing 5.	Replication factor C subunit 2.	0.969
ATAD5	RFC3	ENSCHIP00000016824	ENSCHIP00000010064	ATPase family AAA domain containing 5.	Replication factor C subunit 3.	0.975
ATAD5	RFC4	ENSCHIP00000016824	ENSCHIP00000023106	ATPase family AAA domain containing 5.	Replication factor C subunit 4.	0.988
ATAD5	RFC5	ENSCHIP00000016824	ENSCHIP00000016842	ATPase family AAA domain containing 5.	Replication factor C subunit 5.	0.969
ATAD5	RPA1	ENSCHIP00000016824	ENSCHIP00000032279	ATPase family AAA domain containing 5.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.710
ATAD5	RPA2	ENSCHIP00000016824	ENSCHIP00000020251	ATPase family AAA domain containing 5.	Replication protein A2.	0.485
ATAD5	RPA3	ENSCHIP00000016824	ENSCHIP00000027638	ATPase family AAA domain containing 5.	Uncharacterized protein.	0.446