STRINGSTRING
RPA2 RPA2 PSMA6 PSMA6 RFC4 RFC4 PSMF1 PSMF1 PSMD5 PSMD5 GINS3 GINS3 PSMB9 PSMB9 POLA2 POLA2 ORC2 ORC2 ANAPC1 ANAPC1 ENSCHIP00000024921 ENSCHIP00000024921 ENSCHIP00000025842 ENSCHIP00000025842 ORC6 ORC6 CCNE2 CCNE2 PSME4 PSME4 UBB UBB PSMB6 PSMB6 PSMB10 PSMB10 ENSCHIP00000027563 ENSCHIP00000027563 UBE2E1 UBE2E1 RPA3 RPA3 POLD3 POLD3 ANAPC4 ANAPC4 ENSCHIP00000027691 ENSCHIP00000027691 ANAPC5 ANAPC5 PSMD11 PSMD11 PSME3 PSME3 LOC102169845 LOC102169845 POLE POLE CDK2 CDK2 LOC102188771 LOC102188771 GINS1 GINS1 PSMD13 PSMD13 LOC102176395 LOC102176395 ENSCHIP00000002654 ENSCHIP00000002654 ANAPC2 ANAPC2 ENSCHIP00000001931 ENSCHIP00000001931 PSMD3 PSMD3 ENSCHIP00000001665 ENSCHIP00000001665 PSMB11 PSMB11 LOC102174738 LOC102174738 ENSCHIP00000000668 ENSCHIP00000000668 ENSCHIP00000000212 ENSCHIP00000000212 TM7SF3 TM7SF3 PSMC3 PSMC3 PSME1 PSME1 POLD2 POLD2 LOC102187058 LOC102187058 PSMD10 PSMD10 CDC6 CDC6 PSMA5 PSMA5 FEN1 FEN1 RFC2 RFC2 FAM89A FAM89A ENSCHIP00000004839 ENSCHIP00000004839 ENSCHIP00000007070 ENSCHIP00000007070 ENSCHIP00000007962 ENSCHIP00000007962 MCM5 MCM5 PSMB5 PSMB5 POLD4 POLD4 PSMA4 PSMA4 PSMB3 PSMB3 ENSCHIP00000009163 ENSCHIP00000009163 ENSCHIP00000009219 ENSCHIP00000009219 ENSCHIP00000009691 ENSCHIP00000009691 CDT1 CDT1 PSMA2 PSMA2 RCBTB2 RCBTB2 RFC3 RFC3 ENSCHIP00000010100 ENSCHIP00000010100 PSMB8 PSMB8 ORC1 ORC1 CDC26 CDC26 RCBTB1 RCBTB1 MEIOB MEIOB FAM89B FAM89B RPS27A RPS27A CCNA1 CCNA1 ANAPC11 ANAPC11 ENSCHIP00000011946 ENSCHIP00000011946 MCM8 MCM8 PSMA7 PSMA7 FZR1 FZR1 ENSCHIP00000013851 ENSCHIP00000013851 SKP1 SKP1 PSMC2 PSMC2 UBC UBC ENSCHIP00000014344 ENSCHIP00000014344 PCNA PCNA PSMB7 PSMB7 UBE2C UBE2C ANAPC16 ANAPC16 GINS4 GINS4 TM4SF19 TM4SF19 GINS2 GINS2 PSMC4 PSMC4 ENSCHIP00000016054 ENSCHIP00000016054 PSMA3 PSMA3 ORC5 ORC5 POLA1 POLA1 PSMB2 PSMB2 ATAD5 ATAD5 RFC5 RFC5 PSMC1 PSMC1 PSMD2 PSMD2 PSMD1 PSMD1 PSMC6 PSMC6 MCM6 MCM6 CCNA2 CCNA2 MCM4 MCM4 MCM9 MCM9 PSMD7 PSMD7 POLD1 POLD1 PSMA8 PSMA8 PSMC5 PSMC5 DNA2 DNA2 SKP2 SKP2 ENSCHIP00000021132 ENSCHIP00000021132 LOC102183472 LOC102183472 PSMB4 PSMB4 PSMA1 PSMA1 GMNN GMNN CDK3 CDK3 MCM2 MCM2 CDC27 CDC27 RFC1 RFC1 ANAPC7 ANAPC7 POLE3 POLE3 KXD1 KXD1 MCM7 MCM7 PRIM1 PRIM1 PSMB1 PSMB1 LIG1 LIG1 PSMD8 PSMD8 RPA1 RPA1 PSMD14 PSMD14 PRIM2 PRIM2 CUL1 CUL1 RBX1 RBX1 PSMD4 PSMD4 PSMD12 PSMD12 UBE2S UBE2S ANAPC15 ANAPC15 CDC23 CDC23 CCNE1 CCNE1 UBA52 UBA52 CDC16 CDC16 PSMD6 PSMD6 ORC3 ORC3 POLE2 POLE2 ORC4 ORC4 POLE4 POLE4 PSME2 PSME2 ANAPC10 ANAPC10 PSMD9 PSMD9 MCM3 MCM3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPA2Replication protein A2. (270 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
RFC4Replication factor C subunit 4. (364 aa)
PSMF1Proteasome inhibitor subunit 1. (277 aa)
PSMD5Proteasome 26S subunit, non-ATPase 5. (504 aa)
GINS3GINS complex subunit 3. (216 aa)
PSMB9Proteasome subunit beta 9. (216 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (603 aa)
ORC2Origin recognition complex subunit 2. (596 aa)
ANAPC1Anaphase promoting complex subunit 1. (1905 aa)
ENSCHIP00000024921F-box domain-containing protein. (377 aa)
ENSCHIP00000025842Uncharacterized protein. (185 aa)
ORC6Origin recognition complex subunit 6. (252 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
PSME4Proteasome activator subunit 4. (1840 aa)
UBBUbiquitin B. (323 aa)
PSMB6Proteasome subunit beta. (239 aa)
PSMB10Proteasome subunit beta. (273 aa)
ENSCHIP00000027563MPN domain-containing protein. (302 aa)
UBE2E1Ubiquitin conjugating enzyme E2 E1; Belongs to the ubiquitin-conjugating enzyme family. (202 aa)
RPA3Uncharacterized protein. (121 aa)
POLD3Uncharacterized protein. (464 aa)
ANAPC4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (805 aa)
ENSCHIP00000027691Ubiquitin-like domain-containing protein. (116 aa)
ANAPC5Anaphase promoting complex subunit 5. (747 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
PSME3Proteasome activator subunit 3. (249 aa)
LOC102169845Proteasome subunit alpha type. (234 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2281 aa)
CDK2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (346 aa)
LOC102188771Zf-rbx1 domain-containing protein. (108 aa)
GINS1GINS complex subunit 1. (196 aa)
PSMD13PCI domain-containing protein. (376 aa)
LOC102176395Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
ENSCHIP00000002654Uncharacterized protein. (121 aa)
ANAPC2Anaphase promoting complex subunit 2; Belongs to the cullin family. (843 aa)
ENSCHIP00000001931AAA domain-containing protein. (316 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (537 aa)
ENSCHIP00000001665PROTEASOME_ALPHA_1 domain-containing protein. (229 aa)
PSMB11Proteasome subunit beta 11. (336 aa)
LOC102174738Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
ENSCHIP00000000668Ubiquitin-like domain-containing protein. (103 aa)
ENSCHIP00000000212Uncharacterized protein. (216 aa)
TM7SF3Transmembrane 7 superfamily member 3. (570 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (442 aa)
PSME1Proteasome activator subunit 1. (241 aa)
POLD2DNA polymerase delta 2, accessory subunit. (469 aa)
LOC102187058Proteasome subunit beta. (239 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (226 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (562 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
RFC2Replication factor C subunit 2. (352 aa)
FAM89AFamily with sequence similarity 89 member A. (183 aa)
ENSCHIP00000004839UBIQUITIN_CONJUGAT_2 domain-containing protein. (101 aa)
ENSCHIP00000007070CULLIN_2 domain-containing protein; Belongs to the cullin family. (766 aa)
ENSCHIP00000007962Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (231 aa)
MCM5DNA helicase; Belongs to the MCM family. (734 aa)
PSMB5Proteasome subunit beta. (263 aa)
POLD4Uncharacterized protein. (132 aa)
PSMA4Proteasome subunit alpha type. (284 aa)
PSMB3Proteasome subunit beta. (205 aa)
ENSCHIP00000009163Uncharacterized protein. (122 aa)
ENSCHIP00000009219Ubiquitin-like domain-containing protein. (108 aa)
ENSCHIP00000009691DOC domain-containing protein. (155 aa)
CDT1Chromatin licensing and DNA replication factor 1. (637 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (551 aa)
RFC3Replication factor C subunit 3. (356 aa)
ENSCHIP00000010100Uncharacterized protein. (228 aa)
PSMB8Proteasome subunit beta. (276 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (863 aa)
CDC26Cell division cycle 26. (85 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
MEIOBMeiosis specific with OB-fold. (467 aa)
FAM89BFamily with sequence similarity 89 member B. (192 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (421 aa)
ANAPC11RING-type domain-containing protein. (84 aa)
ENSCHIP00000011946Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
MCM8MCM domain-containing protein; Belongs to the MCM family. (832 aa)
PSMA7Proteasome subunit alpha type. (248 aa)
FZR1Fizzy and cell division cycle 20 related 1. (513 aa)
ENSCHIP00000013851Uncharacterized protein. (113 aa)
SKP1S-phase kinase associated protein 1. (163 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
UBCUbiquitin C. (655 aa)
ENSCHIP00000014344F-box domain-containing protein. (336 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
PSMB7Proteasome subunit beta. (277 aa)
UBE2CUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (172 aa)
ANAPC16Anaphase promoting complex subunit 16. (110 aa)
GINS4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa)
TM4SF19Uncharacterized protein. (202 aa)
GINS2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
ENSCHIP00000016054Uncharacterized protein; Belongs to the SKP1 family. (157 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
ORC5Origin recognition complex subunit 5. (435 aa)
POLA1DNA polymerase. (1468 aa)
PSMB2Proteasome subunit beta. (201 aa)
ATAD5ATPase family AAA domain containing 5. (1894 aa)
RFC5Replication factor C subunit 5. (339 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (979 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
PSMC6AAA domain-containing protein; Belongs to the AAA ATPase family. (403 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (430 aa)
MCM4DNA helicase; Belongs to the MCM family. (851 aa)
MCM9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1137 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (322 aa)
POLD1DNA polymerase. (1115 aa)
PSMA8Proteasome subunit alpha type. (250 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
DNA2DNA replication helicase/nuclease 2. (1062 aa)
SKP2F-box domain-containing protein. (424 aa)
ENSCHIP00000021132Ubiquitin-like domain-containing protein. (127 aa)
LOC102183472PA28_beta domain-containing protein. (200 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
PSMA1Proteasome subunit alpha type. (263 aa)
GMNNGeminin DNA replication inhibitor. (186 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa)
MCM2DNA helicase; Belongs to the MCM family. (1061 aa)
CDC27Cell division cycle 27. (824 aa)
RFC1Replication factor C subunit 1. (1143 aa)
ANAPC7Anaphase promoting complex subunit 7. (598 aa)
POLE3CBFD_NFYB_HMF domain-containing protein. (147 aa)
KXD1KxDL motif containing 1. (176 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
PRIM1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (401 aa)
PSMB1Proteasome subunit beta. (241 aa)
LIG1DNA ligase. (915 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (287 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa)
PSMD14MPN domain-containing protein. (310 aa)
PRIM2Uncharacterized protein. (219 aa)
CUL1CULLIN_2 domain-containing protein; Belongs to the cullin family. (776 aa)
RBX1RING-type domain-containing protein. (108 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (377 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (456 aa)
UBE2SUbiquitin conjugating enzyme E2 S; Belongs to the ubiquitin-conjugating enzyme family. (217 aa)
ANAPC15Anaphase promoting complex subunit 15. (132 aa)
CDC23Cell division cycle 23. (597 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (411 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
CDC16Cell division cycle 16. (620 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (389 aa)
ORC3Origin recognition complex subunit 3. (712 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (518 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (131 aa)
PSME2Proteasome activator subunit 2. (239 aa)
ANAPC10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
PSMD9PDZ domain-containing protein. (221 aa)
MCM3DNA helicase; Belongs to the MCM family. (808 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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