Your Input: | |
| | SFN | Stratifin; Belongs to the 14-3-3 family. (248 aa) |
| | ENSCHIP00000005897 | Reverse transcriptase domain-containing protein. (269 aa) |
| | H2BC6 | Histone H2B type 1. (126 aa) |
| | LOC108633414 | Histone H2B type 1. (126 aa) |
| | ENSCHIP00000006197 | Reverse transcriptase domain-containing protein. (851 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1966 aa) |
| | BLM | BLM RecQ like helicase. (1429 aa) |
| | LOC106503502 | Histone H4. (103 aa) |
| | LOC108636047 | Histone H4. (103 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3058 aa) |
| | ABRAXAS1 | Abraxas 1, BRCA1 A complex subunit. (410 aa) |
| | ENSCHIP00000016214 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (217 aa) |
| | ENSCHIP00000015808 | BRCT domain-containing protein. (262 aa) |
| | CCNB1 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (427 aa) |
| | HERC2 | HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4836 aa) |
| | YWHAH | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa) |
| | BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (1217 aa) |
| | RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (428 aa) |
| | YWHAB | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa) |
| | PIAS4 | Protein inhibitor of activated STAT 4. (513 aa) |
| | ENSCHIP00000014234 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (256 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1056 aa) |
| | RAD1 | Uncharacterized protein. (279 aa) |
| | WRN | WRN RecQ like helicase. (1405 aa) |
| | MDC1 | Mediator of DNA damage checkpoint 1. (1914 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (395 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1002 aa) |
| | UBE2V2 | Ubiquitin conjugating enzyme E2 V2. (148 aa) |
| | RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (241 aa) |
| | LOC102172676 | Histone H2B type 2-E-like. (126 aa) |
| | MEIOB | Meiosis specific with OB-fold. (467 aa) |
| | ENSCHIP00000011074 | annotation not available (103 aa) |
| | LOC106503503 | Histone H4. (103 aa) |
| | LOC102185323 | Histone H2B type 1. (126 aa) |
| | H2BC3 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | RECQL4 | RecQ like helicase 4. (1176 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa) |
| | H2BC11 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSCHIP00000007999 | Uncharacterized protein. (233 aa) |
| | ENSCHIP00000004152 | annotation not available (103 aa) |
| | LOC102180587 | Histone H2B type 1. (126 aa) |
| | ENSCHIP00000008488 | annotation not available (103 aa) |
| | ENSCHIP00000009147 | annotation not available (103 aa) |
| | ENSCHIP00000009200 | annotation not available (103 aa) |
| | ENSCHIP00000009386 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (102 aa) |
| | ENSCHIP00000009605 | Uncharacterized protein. (61 aa) |
| | H2BC15 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSCHIP00000004205 | Reverse transcriptase domain-containing protein. (997 aa) |
| | ENSCHIP00000004308 | annotation not available (103 aa) |
| | ENSCHIP00000004381 | Reverse transcriptase domain-containing protein. (960 aa) |
| | ENSCHIP00000004431 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (245 aa) |
| | LOC102179187 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2BC1 | Histone H2B; Belongs to the histone H2B family. (127 aa) |
| | ENSCHIP00000004577 | Reverse transcriptase domain-containing protein. (738 aa) |
| | RFC2 | Replication factor C subunit 2. (352 aa) |
| | H2BU1 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSCHIP00000005277 | annotation not available (103 aa) |
| | NSD2 | Nuclear receptor binding SET domain protein 2. (1365 aa) |
| | LOC102172954 | Histone H4. (103 aa) |
| | LOC102180845 | Histone H2B type 1. (126 aa) |
| | YWHAQ | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (245 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | H2BE1 | Histone H2B; Belongs to the histone H2B family. (122 aa) |
| | RMI1 | RecQ mediated genome instability 1. (624 aa) |
| | LOC102184017 | Histone H2B type 1. (126 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (889 aa) |
| | EXO1 | Exonuclease 1. (835 aa) |
| | H2BC21 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa) |
| | ENSCHIP00000031621 | Uncharacterized protein. (159 aa) |
| | ENSCHIP00000031435 | Uncharacterized protein. (77 aa) |
| | ENSCHIP00000031302 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (155 aa) |
| | YWHAG | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (247 aa) |
| | ENSCHIP00000030705 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (206 aa) |
| | CHEK1 | Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa) |
| | ENSCHIP00000005753 | annotation not available (103 aa) |
| | ENSCHIP00000033267 | Reverse transcriptase domain-containing protein. (241 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1843 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1521 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa) |
| | BABAM1 | BRISC and BRCA1 A complex member 1. (332 aa) |
| | CDC25C | Cell division cycle 25C. (452 aa) |
| | LOC102186674 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (235 aa) |
| | ATRIP | ATR interacting protein. (791 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (280 aa) |
| | CHEK2 | Checkpoint kinase 2. (534 aa) |
| | RPA3 | Uncharacterized protein. (121 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (573 aa) |
| | YWHAE | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (243 aa) |
| | ENSCHIP00000027126 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (132 aa) |
| | ENSCHIP00000027031 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (240 aa) |
| | UIMC1 | Ubiquitin interaction motif containing 1. (795 aa) |
| | ENSCHIP00000026297 | Histone domain-containing protein; Belongs to the histone H2B family. (112 aa) |
| | ENSCHIP00000025754 | Uncharacterized protein; Belongs to the cyclin family. (386 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (642 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (775 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (724 aa) |
| | RMI2 | Uncharacterized protein. (161 aa) |
| | ENSCHIP00000024011 | 14_3_3 domain-containing protein. (93 aa) |
| | ENSCHIP00000023759 | Uncharacterized protein; Belongs to the cyclin family. (388 aa) |
| | RFC4 | Replication factor C subunit 4. (364 aa) |
| | RAD17 | RAD17 checkpoint clamp loader component. (709 aa) |
| | YWHAZ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide; Belongs to the 14-3-3 family. (245 aa) |
| | TDRD3 | Tudor domain containing 3. (762 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1062 aa) |
| | RPA2 | Replication protein A2. (270 aa) |
| | WEE2 | Wee1-like protein kinase. (566 aa) |
| | BRCC3 | MPN domain-containing protein. (288 aa) |
| | WEE1 | Wee1-like protein kinase. (645 aa) |
| | RFC5 | Replication factor C subunit 5. (339 aa) |
| | ENSCHIP00000003806 | Reverse transcriptase domain-containing protein. (310 aa) |
| | LOC102172226 | Histone domain-containing protein; Belongs to the histone H2B family. (126 aa) |
| | H2BC18 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC102182181 | Histone H2B type 1. (126 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (504 aa) |
| | LOC102183280 | Histone H2B type 1. (126 aa) |
| | ENSCHIP00000003174 | Endo/exonuclease/phosphatase domain-containing protein. (426 aa) |
| | RAD50 | Zinc-hook domain-containing protein. (1332 aa) |
| | LOC102175243 | Histone domain-containing protein; Belongs to the histone H2B family. (122 aa) |
| | LOC102181912 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | RNF169 | Ring finger protein 169. (708 aa) |
| | ENSCHIP00000002654 | Uncharacterized protein. (121 aa) |
| | ENSCHIP00000001833 | Reverse transcriptase domain-containing protein. (304 aa) |
| | BABAM2 | BRISC and BRCA1 A complex member 2. (383 aa) |
| | LOC102180307 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | ENSCHIP00000001380 | Reverse transcriptase domain-containing protein. (704 aa) |
| | ENSCHIP00000001154 | Reverse transcriptase domain-containing protein. (730 aa) |
| | H2BC12 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSCHIP00000000954 | Reverse transcriptase domain-containing protein. (679 aa) |
| | ENSCHIP00000000835 | Reverse transcriptase domain-containing protein. (303 aa) |
| | ENSCHIP00000000787 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (245 aa) |
| | CDK1 | Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (312 aa) |
| | LOC102176379 | Wee1-like protein kinase. (549 aa) |
| | ENSCHIP00000000047 | RING-type domain-containing protein. (101 aa) |
