(10 nodes) Signal attenuation network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	LOC106504022	Uncharacterized protein. (553 aa)
	GRB10	Growth factor receptor bound protein 10. (591 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1318 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
	INSR	Tyrosine-protein kinase receptor. (1365 aa)
	SHC1	SHC adaptor protein 1. (583 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
	IRS2	Insulin receptor substrate 2. (1465 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (396 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GRB10	GRB2	ENSCHIP00000025373	ENSCHIP00000015407	Growth factor receptor bound protein 10.	Growth factor receptor bound protein 2.	0.768
GRB10	INS	ENSCHIP00000025373	ENSCHIP00000007610	Growth factor receptor bound protein 10.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.834
GRB10	INSR	ENSCHIP00000025373	ENSCHIP00000012457	Growth factor receptor bound protein 10.	Tyrosine-protein kinase receptor.	0.904
GRB10	IRS2	ENSCHIP00000025373	ENSCHIP00000000977	Growth factor receptor bound protein 10.	Insulin receptor substrate 2.	0.600
GRB10	LOC106504022	ENSCHIP00000025373	ENSCHIP00000029351	Growth factor receptor bound protein 10.	Uncharacterized protein.	0.566
GRB10	SHC1	ENSCHIP00000025373	ENSCHIP00000010307	Growth factor receptor bound protein 10.	SHC adaptor protein 1.	0.419
GRB2	GRB10	ENSCHIP00000015407	ENSCHIP00000025373	Growth factor receptor bound protein 2.	Growth factor receptor bound protein 10.	0.768
GRB2	INS	ENSCHIP00000015407	ENSCHIP00000007610	Growth factor receptor bound protein 2.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.804
GRB2	INSR	ENSCHIP00000015407	ENSCHIP00000012457	Growth factor receptor bound protein 2.	Tyrosine-protein kinase receptor.	0.974
GRB2	IRS2	ENSCHIP00000015407	ENSCHIP00000000977	Growth factor receptor bound protein 2.	Insulin receptor substrate 2.	0.994
GRB2	LOC106504022	ENSCHIP00000015407	ENSCHIP00000029351	Growth factor receptor bound protein 2.	Uncharacterized protein.	0.877
GRB2	MAPK1	ENSCHIP00000015407	ENSCHIP00000000204	Growth factor receptor bound protein 2.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.720
GRB2	MAPK3	ENSCHIP00000015407	ENSCHIP00000015503	Growth factor receptor bound protein 2.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.417
GRB2	SHC1	ENSCHIP00000015407	ENSCHIP00000010307	Growth factor receptor bound protein 2.	SHC adaptor protein 1.	0.999
GRB2	SOS1	ENSCHIP00000015407	ENSCHIP00000020128	Growth factor receptor bound protein 2.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.999
INS	GRB10	ENSCHIP00000007610	ENSCHIP00000025373	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Growth factor receptor bound protein 10.	0.834
INS	GRB2	ENSCHIP00000007610	ENSCHIP00000015407	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Growth factor receptor bound protein 2.	0.804
INS	INSR	ENSCHIP00000007610	ENSCHIP00000012457	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Tyrosine-protein kinase receptor.	0.999
INS	IRS2	ENSCHIP00000007610	ENSCHIP00000000977	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin receptor substrate 2.	0.991
INS	LOC106504022	ENSCHIP00000007610	ENSCHIP00000029351	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.924