STRINGSTRING
FGFR2 FGFR2 MAPK1 MAPK1 ENSCHIP00000000483 ENSCHIP00000000483 IRS2 IRS2 FGF3 FGF3 PIK3R2 PIK3R2 KL KL FLT3 FLT3 FGFR3 FGFR3 PDE3B PDE3B FGF4 FGF4 FRS2 FRS2 FGFR1 FGFR1 INS INS FGF18 FGF18 FGF16 FGF16 ENSCHIP00000009861 ENSCHIP00000009861 FGF10 FGF10 SHC1 SHC1 FGF19 FGF19 FLT3LG FLT3LG FGF6 FGF6 INSR INSR FGF20 FGF20 AKT2 AKT2 PDPK1 PDPK1 THEM4 THEM4 PIK3C3 PIK3C3 FGF7 FGF7 GRB2 GRB2 MAPK3 MAPK3 PIK3CA PIK3CA SPEM2 SPEM2 FGF23 FGF23 FGF8 FGF8 GAB2 GAB2 FGF2 FGF2 LOC108635484 LOC108635484 SOS1 SOS1 LOC102169118 LOC102169118 ENSCHIP00000020708 ENSCHIP00000020708 PTPN11 PTPN11 PIK3CB PIK3CB TRIB3 TRIB3 FGF9 FGF9 PIK3R1 PIK3R1 GRB10 GRB10 ENSCHIP00000027249 ENSCHIP00000027249 AKT1 AKT1 FGFR4 FGFR4 SPEM1 SPEM1 KLB KLB TLR9 TLR9 LOC106504022 LOC106504022 GAB1 GAB1 FGF5 FGF5 PIK3R4 PIK3R4 FGF17 FGF17 FGF1 FGF1 FGF22 FGF22
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGFR2Fibroblast growth factor receptor. (841 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (396 aa)
ENSCHIP00000000483Uncharacterized protein. (304 aa)
IRS2Insulin receptor substrate 2. (1465 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (232 aa)
PIK3R2Uncharacterized protein. (724 aa)
KLKlotho. (1013 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (992 aa)
FGFR3Receptor protein-tyrosine kinase. (710 aa)
PDE3BPhosphodiesterase. (1115 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
FGFR1Fibroblast growth factor receptor. (860 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
ENSCHIP00000009861Protein kinase domain-containing protein. (292 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
SHC1SHC adaptor protein 1. (583 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
FLT3LGFms related tyrosine kinase 3 ligand. (290 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
INSRTyrosine-protein kinase receptor. (1365 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (557 aa)
THEM4Thioesterase superfamily member 4. (268 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (900 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
SPEM2SPEM family member 2. (495 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (245 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
GAB2GRB2 associated binding protein 2. (680 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
LOC108635484Protein kinase domain-containing protein. (677 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1318 aa)
LOC102169118Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (605 aa)
ENSCHIP00000020708Protein kinase domain-containing protein. (969 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
TRIB3Tribbles pseudokinase 3. (357 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
GRB10Growth factor receptor bound protein 10. (591 aa)
ENSCHIP00000027249Protein kinase domain-containing protein. (292 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (495 aa)
FGFR4Fibroblast growth factor receptor. (870 aa)
SPEM1Spermatid maturation 1. (313 aa)
KLBKlotho beta. (1032 aa)
TLR9TIR domain-containing protein. (1070 aa)
LOC106504022Uncharacterized protein. (553 aa)
GAB1GRB2 associated binding protein 1. (751 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (270 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1310 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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