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ATP6V1A ATP6V1A ATP6V0E1 ATP6V0E1 SESN2 SESN2 DMRTA1 DMRTA1 ATP6V0C ATP6V0C ATP6V1E1 ATP6V1E1 WDR24 WDR24 ATP6V0D2 ATP6V0D2 TCIRG1 TCIRG1 KIAA1671 KIAA1671 FNIP1 FNIP1 RPTOR RPTOR LOC102180669 LOC102180669 ENSCHIP00000022631 ENSCHIP00000022631 LOC102185906 LOC102185906 RRAGD RRAGD ATP6V1D ATP6V1D LOC108635156 LOC108635156 DMRTC2 DMRTC2 DMRT2 DMRT2 MTOR MTOR KPTN KPTN TXNDC11 TXNDC11 DMRTB1 DMRTB1 ITFG2 ITFG2 CASTOR2 CASTOR2 RRAGB RRAGB SLC38A9 SLC38A9 ENSCHIP00000018746 ENSCHIP00000018746 ATP6V1C1 ATP6V1C1 SESN1 SESN1 ATP6V0D1 ATP6V0D1 FNIP2 FNIP2 RHEB RHEB ATP6V0B ATP6V0B ATP6V1C2 ATP6V1C2 LAMTOR5 LAMTOR5 NPRL2 NPRL2 ATP6V1B2 ATP6V1B2 RHEBL1 RHEBL1 ENSCHIP00000016240 ENSCHIP00000016240 ATP6V1H ATP6V1H DEPDC5 DEPDC5 ATP6V1G1 ATP6V1G1 MACC1 MACC1 ATF3 ATF3 SEC13 SEC13 ATF4 ATF4 RRAGC RRAGC ATP6V1B1 ATP6V1B1 CASTOR1 CASTOR1 DMRTA2 DMRTA2 SH3BP4 SH3BP4 NPRL3 NPRL3 DMRT3 DMRT3 LAMTOR1 LAMTOR1 LIM2 LIM2 ENSCHIP00000009480 ENSCHIP00000009480 CNST CNST DDIT3 DDIT3 ATP6V0E2 ATP6V0E2 ENSCHIP00000008002 ENSCHIP00000008002 MIOS MIOS LAMTOR4 LAMTOR4 ENSCHIP00000007345 ENSCHIP00000007345 ATP6V1G3 ATP6V1G3 WDR59 WDR59 CRYBB3 CRYBB3 CEBPG CEBPG PPP1R3A PPP1R3A ATP6V1F ATP6V1F ENSCHIP00000004243 ENSCHIP00000004243 EIF2AK4 EIF2AK4 SEH1L SEH1L MLST8 MLST8 RRAGA RRAGA METTL25 METTL25 ATP6V1E2 ATP6V1E2 C12orf66 C12orf66 IMPACT IMPACT FLCN FLCN CRYGN CRYGN LAMTOR2 LAMTOR2 BMT2 BMT2 SESN3 SESN3 SZT2 SZT2 ENSCHIP00000030469 ENSCHIP00000030469 GCN1 GCN1 ATP6V1G2 ATP6V1G2 LAMTOR3 LAMTOR3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ATP6V1AATPase H+ transporting V1 subunit A. (618 aa)
ATP6V0E1Uncharacterized protein. (81 aa)
SESN2Sestrin 2. (471 aa)
DMRTA1DMRT like family A1. (496 aa)
ATP6V0CV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
ATP6V1E1ATPase H+ transporting V1 subunit E1. (226 aa)
WDR24WD repeat domain 24. (790 aa)
ATP6V0D2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (829 aa)
KIAA1671KIAA1671. (1805 aa)
FNIP1Folliculin interacting protein 1. (1162 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1342 aa)
LOC102180669DM domain-containing protein. (203 aa)
ENSCHIP00000022631Uncharacterized protein. (89 aa)
LOC102185906Uncharacterized protein. (239 aa)
RRAGDRas related GTP binding D. (439 aa)
ATP6V1DUncharacterized protein. (237 aa)
LOC108635156WD_REPEATS_REGION domain-containing protein; Belongs to the WD repeat SEC13 family. (274 aa)
DMRTC2DMRT like family C2. (370 aa)
DMRT2Doublesex and mab-3 related transcription factor 2. (558 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
KPTNKaptin, actin binding protein. (464 aa)
TXNDC11Thioredoxin domain containing 11. (955 aa)
DMRTB1Uncharacterized protein. (184 aa)
ITFG2Integrin alpha FG-GAP repeat containing 2. (444 aa)
CASTOR2Uncharacterized protein. (331 aa)
RRAGBRas related GTP binding B. (374 aa)
SLC38A9Solute carrier family 38 member 9. (561 aa)
ENSCHIP00000018746Uncharacterized protein. (84 aa)
ATP6V1C1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
SESN1Sestrin 1. (552 aa)
ATP6V0D1V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
FNIP2Folliculin interacting protein 2. (1104 aa)
RHEBUncharacterized protein. (187 aa)
ATP6V0BATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (205 aa)
ATP6V1C2V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (427 aa)
LAMTOR5Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (91 aa)
NPRL2NPR2 like, GATOR1 complex subunit. (380 aa)
ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (511 aa)
RHEBL1RHEB like 1. (183 aa)
ENSCHIP00000016240Uncharacterized protein. (67 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa)
DEPDC5DEP domain-containing protein. (1563 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
MACC1MET transcriptional regulator MACC1. (852 aa)
ATF3Activating transcription factor 3. (181 aa)
SEC13WD_REPEATS_REGION domain-containing protein; Belongs to the WD repeat SEC13 family. (322 aa)
ATF4Activating transcription factor 4. (352 aa)
RRAGCRas related GTP binding C. (399 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
CASTOR1Cytosolic arginine sensor for mTORC1 subunit 1. (329 aa)
DMRTA2DMRT like family A2. (535 aa)
SH3BP4SH3 domain binding protein 4. (963 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (569 aa)
DMRT3Doublesex and mab-3 related transcription factor 3. (472 aa)
LAMTOR1Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (161 aa)
LIM2Lens fiber membrane intrinsic protein; Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis; Belongs to the PMP-22/EMP/MP20 family. (173 aa)
ENSCHIP00000009480V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
CNSTConsortin, connexin sorting protein. (721 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
ATP6V0E2V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
ENSCHIP00000008002Uncharacterized protein. (112 aa)
MIOSMeiosis regulator for oocyte development. (876 aa)
LAMTOR4Late endosomal/lysosomal adaptor, MAPK and MTOR activator 4. (98 aa)
ENSCHIP00000007345Uncharacterized protein. (285 aa)
ATP6V1G3V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
WDR59WD repeat domain 59. (923 aa)
CRYBB3Crystallin beta B3; Belongs to the beta/gamma-crystallin family. (211 aa)
CEBPGCCAAT enhancer binding protein gamma. (149 aa)
PPP1R3AProtein phosphatase 1 regulatory subunit 3A. (1148 aa)
ATP6V1FV-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa)
ENSCHIP00000004243Uncharacterized protein. (91 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1649 aa)
SEH1LSEH1 like nucleoporin; Belongs to the WD repeat SEC13 family. (422 aa)
MLST8MTOR associated protein, LST8 homolog. (338 aa)
RRAGARas related GTP binding A. (313 aa)
METTL25Methyltransferase like 25. (601 aa)
ATP6V1E2ATPase H+ transporting V1 subunit E2. (226 aa)
C12orf66Chromosome 12 open reading frame 66. (445 aa)
IMPACTImpact RWD domain protein. (318 aa)
FLCNUDENN FLCN/SMCR8-type domain-containing protein. (579 aa)
CRYGNCrystallin gamma N; Belongs to the beta/gamma-crystallin family. (183 aa)
LAMTOR2Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2. (125 aa)
BMT2S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (405 aa)
SESN3Sestrin 3. (492 aa)
SZT2SZT2 subunit of KICSTOR complex. (3427 aa)
ENSCHIP00000030469Uncharacterized protein. (160 aa)
GCN1GCN1 activator of EIF2AK4. (2657 aa)
ATP6V1G2V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
LAMTOR3Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3. (124 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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