STRINGSTRING
FOS FOS MAPK8 MAPK8 MAP2K4 MAP2K4 ENSCHIP00000031302 ENSCHIP00000031302 CUL1 CUL1 ATF7 ATF7 LOC102180290 LOC102180290 MAP3K1 MAP3K1 APP APP MAPKAPK2 MAPKAPK2 UBE2V1 UBE2V1 NKIRAS2 NKIRAS2 CREB1 CREB1 KXD1 KXD1 MAPK1 MAPK1 LRRC74B LRRC74B ENSCHIP00000000668 ENSCHIP00000000668 MAPK14 MAPK14 LOC102174738 LOC102174738 RPS6KA4 RPS6KA4 TAB3 TAB3 JUN JUN LRRC71 LRRC71 TRAF2 TRAF2 USP14 USP14 LRRC74A LRRC74A ENSCHIP00000003440 ENSCHIP00000003440 JUNB JUNB CCDC71L CCDC71L PPP2CB PPP2CB NFKB1 NFKB1 DUSP7 DUSP7 ELK1 ELK1 FOSL2 FOSL2 DUSP4 DUSP4 DUSP6 DUSP6 ATF2 ATF2 ENSCHIP00000008753 ENSCHIP00000008753 MAP3K7 MAP3K7 LRRC14 LRRC14 ENSCHIP00000009219 ENSCHIP00000009219 IRAK1 IRAK1 NKIRAS1 NKIRAS1 LOC108637886 LOC108637886 MAPK10 MAPK10 LOC100860781 LOC100860781 S100A12 S100A12 FNBP4 FNBP4 RPS27A RPS27A AGER AGER TNIP2 TNIP2 ENSCHIP00000011946 ENSCHIP00000011946 MAPK7 MAPK7 MAPKAPK3 MAPKAPK3 MAPK9 MAPK9 MAP2K3 MAP2K3 IKBKB IKBKB TAB1 TAB1 ENSCHIP00000013634 ENSCHIP00000013634 RELA RELA RPS6KA1 RPS6KA1 SKP1 SKP1 UBC UBC PPP4R4 PPP4R4 PELI2 PELI2 KHNYN KHNYN FBXW11 FBXW11 TRAF6 TRAF6 MAP3K20 MAP3K20 TONSL TONSL MAPK3 MAPK3 ENSCHIP00000016054 ENSCHIP00000016054 RPS6KA2 RPS6KA2 LOC106503728 LOC106503728 ATF1 ATF1 CHUK CHUK RPS6KA5 RPS6KA5 VRK3 VRK3 PPP4R1 PPP4R1 CREB5 CREB5 NLRX1 NLRX1 NLRC5 NLRC5 MAP3K8 MAP3K8 RELCH RELCH HMGB1 HMGB1 RIPK2 RIPK2 MAPK11 MAPK11 PPP2R5D PPP2R5D CASP8 CASP8 NOD1 NOD1 LRRC31 LRRC31 ENSCHIP00000021132 ENSCHIP00000021132 N4BP1 N4BP1 PELI3 PELI3 NFKB2 NFKB2 PPP2R1B PPP2R1B VWC2 VWC2 TAB2 TAB2 IRAK2 IRAK2 MAP2K7 MAP2K7 S100B S100B ENSCHIP00000024230 ENSCHIP00000024230 ECSIT ECSIT PELI1 PELI1 LOC102168428 LOC102168428 MAPK15 MAPK15 RPS6KA3 RPS6KA3 LOC102168699 LOC102168699 UBB UBB NFKBIB NFKBIB ENSCHIP00000027126 ENSCHIP00000027126 PPP2R1A PPP2R1A ENSCHIP00000027691 ENSCHIP00000027691 IKBKG IKBKG LOC102168979 LOC102168979 DUSP3 DUSP3 PPP2CA PPP2CA LRRC45 LRRC45 UBA52 UBA52 MAP2K6 MAP2K6 NOD2 NOD2 NLRP9 NLRP9 LRRC34 LRRC34 LOC102173207 LOC102173207
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
MAPK8Mitogen-activated protein kinase. (442 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (412 aa)
ENSCHIP00000031302UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (155 aa)
CUL1CULLIN_2 domain-containing protein; Belongs to the cullin family. (776 aa)
ATF7Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. (483 aa)
LOC102180290USP domain-containing protein; Belongs to the peptidase C19 family. (349 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1507 aa)
APPAmyloid beta precursor protein. (770 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (410 aa)
UBE2V1Ubiquitin conjugating enzyme E2 V1. (147 aa)
NKIRAS2NFKB inhibitor interacting Ras like 2. (191 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
KXD1KxDL motif containing 1. (176 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (396 aa)
LRRC74BLeucine rich repeat containing 74B. (374 aa)
ENSCHIP00000000668Ubiquitin-like domain-containing protein. (103 aa)
MAPK14Mitogen-activated protein kinase. (350 aa)
LOC102174738Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
RPS6KA4Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (752 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (717 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
LRRC71Leucine rich repeat containing 71. (560 aa)
TRAF2TNF receptor-associated factor. (497 aa)
USP14Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (494 aa)
LRRC74ALeucine rich repeat containing 74A. (494 aa)
ENSCHIP00000003440Uncharacterized protein. (94 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
CCDC71LCoiled-coil domain containing 71 like. (233 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
DUSP7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (419 aa)
ELK1ETS transcription factor ELK1. (440 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (327 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ENSCHIP00000008753Uncharacterized protein. (589 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
LRRC14Leucine rich repeat containing 14. (493 aa)
ENSCHIP00000009219Ubiquitin-like domain-containing protein. (108 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (718 aa)
NKIRAS1NFKB inhibitor interacting Ras like 1. (192 aa)
LOC108637886Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform. (309 aa)
MAPK10Mitogen-activated protein kinase. (426 aa)
LOC100860781Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (128 aa)
S100A12Protein S100; Belongs to the S-100 family. (92 aa)
FNBP4Formin binding protein 4. (1017 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
AGERAdvanced glycosylation end-product specific receptor. (416 aa)
TNIP2TNFAIP3 interacting protein 2. (429 aa)
ENSCHIP00000011946Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (780 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (384 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (349 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
ENSCHIP00000013634Uncharacterized protein. (189 aa)
RELARELA proto-oncogene, NF-kB subunit. (571 aa)
RPS6KA1Ribosomal protein S6 kinase. (760 aa)
SKP1S-phase kinase associated protein 1. (163 aa)
UBCUbiquitin C. (655 aa)
PPP4R4Protein phosphatase 4 regulatory subunit 4. (874 aa)
PELI2E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (412 aa)
KHNYNKH and NYN domain containing. (670 aa)
FBXW11F-box and WD repeat domain containing 11. (563 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (573 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase 20. (800 aa)
TONSLTonsoku like, DNA repair protein. (1371 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
ENSCHIP00000016054Uncharacterized protein; Belongs to the SKP1 family. (157 aa)
RPS6KA2Ribosomal protein S6 kinase. (760 aa)
LOC106503728Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (130 aa)
ATF1Activating transcription factor 1. (310 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (740 aa)
RPS6KA5Ribosomal protein S6 kinase. (827 aa)
VRK3VRK serine/threonine kinase 3. (434 aa)
PPP4R1Protein phosphatase 4 regulatory subunit 1. (922 aa)
CREB5cAMP responsive element binding protein 5. (549 aa)
NLRX1NLR family member X1. (973 aa)
NLRC5NLR family CARD domain containing 5. (1868 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (468 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1212 aa)
HMGB1Uncharacterized protein. (215 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (537 aa)
MAPK11Mitogen-activated protein kinase. (417 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (590 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (488 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (954 aa)
LRRC31Leucine rich repeat containing 31. (480 aa)
ENSCHIP00000021132Ubiquitin-like domain-containing protein. (127 aa)
N4BP1NEDD4 binding protein 1. (897 aa)
PELI3E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (445 aa)
NFKB2Nuclear factor kappa B subunit 2. (900 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (615 aa)
VWC2Von Willebrand factor C domain containing 2. (326 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (622 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (558 aa)
S100BProtein S100; Belongs to the S-100 family. (92 aa)
ENSCHIP00000024230Serine/threonine-protein phosphatase. (303 aa)
ECSITECSIT signalling integrator. (431 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
LOC102168428Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (133 aa)
MAPK15Mitogen-activated protein kinase. (543 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
LOC102168699Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (130 aa)
UBBUbiquitin B. (323 aa)
NFKBIBNFKB inhibitor beta. (364 aa)
ENSCHIP00000027126UBIQUITIN_CONJUGAT_2 domain-containing protein. (132 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (598 aa)
ENSCHIP00000027691Ubiquitin-like domain-containing protein. (116 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (408 aa)
LOC102168979Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (130 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (185 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
LRRC45Leucine rich repeat containing 45. (671 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (344 aa)
NOD2Uncharacterized protein. (982 aa)
NLRP9NLR family pyrin domain containing 9. (1037 aa)
LRRC34Leucine rich repeat containing 34. (451 aa)
LOC102173207TMEM189_B_dmain domain-containing protein. (271 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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