10 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RECQL4	RecQ like helicase 4. (1176 aa)
	LMNB2	Lamin B2; Belongs to the intermediate filament family. (641 aa)
	LMNB1	Lamin B1; Belongs to the intermediate filament family. (586 aa)
	WRN	WRN RecQ like helicase. (1405 aa)
	PXDN	Peroxidasin. (1525 aa)
	RECQL	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (649 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
	RAD50	Zinc-hook domain-containing protein. (1332 aa)
	RAD52	RAD52 homolog, DNA repair protein. (416 aa)
	RECQL5	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (991 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LMNB1	LMNB2	ENSCHIP00000011489	ENSCHIP00000011094	Lamin B1; Belongs to the intermediate filament family.	Lamin B2; Belongs to the intermediate filament family.	0.955
LMNB1	PXDN	ENSCHIP00000011489	ENSCHIP00000015493	Lamin B1; Belongs to the intermediate filament family.	Peroxidasin.	0.801
LMNB1	TP53	ENSCHIP00000011489	ENSCHIP00000030141	Lamin B1; Belongs to the intermediate filament family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.727
LMNB2	LMNB1	ENSCHIP00000011094	ENSCHIP00000011489	Lamin B2; Belongs to the intermediate filament family.	Lamin B1; Belongs to the intermediate filament family.	0.955
LMNB2	PXDN	ENSCHIP00000011094	ENSCHIP00000015493	Lamin B2; Belongs to the intermediate filament family.	Peroxidasin.	0.763
LMNB2	TP53	ENSCHIP00000011094	ENSCHIP00000030141	Lamin B2; Belongs to the intermediate filament family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.641
PXDN	LMNB1	ENSCHIP00000015493	ENSCHIP00000011489	Peroxidasin.	Lamin B1; Belongs to the intermediate filament family.	0.801
PXDN	LMNB2	ENSCHIP00000015493	ENSCHIP00000011094	Peroxidasin.	Lamin B2; Belongs to the intermediate filament family.	0.763
PXDN	TP53	ENSCHIP00000015493	ENSCHIP00000030141	Peroxidasin.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.893
RAD50	RAD52	ENSCHIP00000003154	ENSCHIP00000004740	Zinc-hook domain-containing protein.	RAD52 homolog, DNA repair protein.	0.904
RAD50	RECQL4	ENSCHIP00000003154	ENSCHIP00000007755	Zinc-hook domain-containing protein.	RecQ like helicase 4.	0.817
RAD50	RECQL5	ENSCHIP00000003154	ENSCHIP00000005703	Zinc-hook domain-containing protein.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.757
RAD50	TP53	ENSCHIP00000003154	ENSCHIP00000030141	Zinc-hook domain-containing protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.522
RAD50	WRN	ENSCHIP00000003154	ENSCHIP00000013642	Zinc-hook domain-containing protein.	WRN RecQ like helicase.	0.937
RAD52	RAD50	ENSCHIP00000004740	ENSCHIP00000003154	RAD52 homolog, DNA repair protein.	Zinc-hook domain-containing protein.	0.904
RAD52	RECQL	ENSCHIP00000004740	ENSCHIP00000029033	RAD52 homolog, DNA repair protein.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.549
RAD52	RECQL4	ENSCHIP00000004740	ENSCHIP00000007755	RAD52 homolog, DNA repair protein.	RecQ like helicase 4.	0.915
RAD52	RECQL5	ENSCHIP00000004740	ENSCHIP00000005703	RAD52 homolog, DNA repair protein.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.882
RAD52	TP53	ENSCHIP00000004740	ENSCHIP00000030141	RAD52 homolog, DNA repair protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.545
RAD52	WRN	ENSCHIP00000004740	ENSCHIP00000013642	RAD52 homolog, DNA repair protein.	WRN RecQ like helicase.	0.995