6 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HDAC2	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
	FOXA1	Forkhead box A1. (468 aa)
	AR	Androgen receptor. (891 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (192 aa)
	FOXA2	Forkhead box A2. (467 aa)
	ACTB	Uncharacterized protein. (375 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	AR	ENSCHIP00000011080	ENSCHIP00000024342	Uncharacterized protein.	Androgen receptor.	0.792
ACTB	FOXA1	ENSCHIP00000011080	ENSCHIP00000027706	Uncharacterized protein.	Forkhead box A1.	0.421
ACTB	FOXA2	ENSCHIP00000011080	ENSCHIP00000011890	Uncharacterized protein.	Forkhead box A2.	0.541
ACTB	HDAC2	ENSCHIP00000011080	ENSCHIP00000028926	Uncharacterized protein.	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.719
ACTB	LEP	ENSCHIP00000011080	ENSCHIP00000021235	Uncharacterized protein.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...]	0.846
AR	ACTB	ENSCHIP00000024342	ENSCHIP00000011080	Androgen receptor.	Uncharacterized protein.	0.792
AR	FOXA1	ENSCHIP00000024342	ENSCHIP00000027706	Androgen receptor.	Forkhead box A1.	0.935
AR	FOXA2	ENSCHIP00000024342	ENSCHIP00000011890	Androgen receptor.	Forkhead box A2.	0.653
AR	HDAC2	ENSCHIP00000024342	ENSCHIP00000028926	Androgen receptor.	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.584
AR	LEP	ENSCHIP00000024342	ENSCHIP00000021235	Androgen receptor.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...]	0.863
FOXA1	ACTB	ENSCHIP00000027706	ENSCHIP00000011080	Forkhead box A1.	Uncharacterized protein.	0.421
FOXA1	AR	ENSCHIP00000027706	ENSCHIP00000024342	Forkhead box A1.	Androgen receptor.	0.935
FOXA1	FOXA2	ENSCHIP00000027706	ENSCHIP00000011890	Forkhead box A1.	Forkhead box A2.	0.415
FOXA1	HDAC2	ENSCHIP00000027706	ENSCHIP00000028926	Forkhead box A1.	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.417
FOXA1	LEP	ENSCHIP00000027706	ENSCHIP00000021235	Forkhead box A1.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...]	0.566
FOXA2	ACTB	ENSCHIP00000011890	ENSCHIP00000011080	Forkhead box A2.	Uncharacterized protein.	0.541
FOXA2	AR	ENSCHIP00000011890	ENSCHIP00000024342	Forkhead box A2.	Androgen receptor.	0.653
FOXA2	FOXA1	ENSCHIP00000011890	ENSCHIP00000027706	Forkhead box A2.	Forkhead box A1.	0.415
HDAC2	ACTB	ENSCHIP00000028926	ENSCHIP00000011080	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Uncharacterized protein.	0.719
HDAC2	AR	ENSCHIP00000028926	ENSCHIP00000024342	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Androgen receptor.	0.584