(22 nodes) (2011) HMGB factors are required for posterior digit development through integrating signaling pathway activities. network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PTCH1	Patched 1. (1453 aa)
	MSX1	Msh homeobox 1. (303 aa)
	DKK1	Dickkopf WNT signaling pathway inhibitor 1. (262 aa)
	GLI3	GLI family zinc finger 3. (1614 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
	NR3C1	Nuclear receptor subfamily 3 group C member 1. (781 aa)
	PAX9	Paired box 9. (342 aa)
	WNT3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
	LMX1B	LIM homeobox transcription factor 1 beta. (402 aa)
	AXIN2	Axin 2. (844 aa)
	MSX2-2	Uncharacterized protein. (154 aa)
	SOX9	SRY-box transcription factor 9. (525 aa)
	WNT7A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
	MSX2	Homeobox domain-containing protein. (267 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
	LEF1	HMG box domain-containing protein. (430 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	GLI1	GLI family zinc finger 1. (1105 aa)
	WNT9A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (376 aa)
	HMGB4	High mobility group box 4. (194 aa)
	HOXD13	Homeobox D13. (340 aa)
	CCND1	Cyclin D1; Belongs to the cyclin family. (295 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AXIN2	CCND1	ENSCHIP00000022676	ENSCHIP00000006815	Axin 2.	Cyclin D1; Belongs to the cyclin family.	0.845
AXIN2	CTNNB1	ENSCHIP00000022676	ENSCHIP00000031016	Axin 2.	Catenin beta 1.	0.998
AXIN2	DKK1	ENSCHIP00000022676	ENSCHIP00000013400	Axin 2.	Dickkopf WNT signaling pathway inhibitor 1.	0.901
AXIN2	GLI1	ENSCHIP00000022676	ENSCHIP00000003321	Axin 2.	GLI family zinc finger 1.	0.710
AXIN2	GLI3	ENSCHIP00000022676	ENSCHIP00000014153	Axin 2.	GLI family zinc finger 3.	0.489
AXIN2	LEF1	ENSCHIP00000022676	ENSCHIP00000030629	Axin 2.	HMG box domain-containing protein.	0.955
AXIN2	MSX1	ENSCHIP00000022676	ENSCHIP00000012268	Axin 2.	Msh homeobox 1.	0.544
AXIN2	MSX2	ENSCHIP00000022676	ENSCHIP00000027425	Axin 2.	Homeobox domain-containing protein.	0.556
AXIN2	MSX2-2	ENSCHIP00000022676	ENSCHIP00000023401	Axin 2.	Uncharacterized protein.	0.556
AXIN2	PAX9	ENSCHIP00000022676	ENSCHIP00000017561	Axin 2.	Paired box 9.	0.458
AXIN2	PTCH1	ENSCHIP00000022676	ENSCHIP00000011891	Axin 2.	Patched 1.	0.601
AXIN2	SHH	ENSCHIP00000022676	ENSCHIP00000027767	Axin 2.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.705
AXIN2	SOX9	ENSCHIP00000022676	ENSCHIP00000024523	Axin 2.	SRY-box transcription factor 9.	0.731
AXIN2	WNT3	ENSCHIP00000022676	ENSCHIP00000020033	Axin 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.841
AXIN2	WNT5A	ENSCHIP00000022676	ENSCHIP00000015533	Axin 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.893
AXIN2	WNT7A	ENSCHIP00000022676	ENSCHIP00000025727	Axin 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.771
AXIN2	WNT9A	ENSCHIP00000022676	ENSCHIP00000005413	Axin 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.743
CCND1	AXIN2	ENSCHIP00000006815	ENSCHIP00000022676	Cyclin D1; Belongs to the cyclin family.	Axin 2.	0.845
CCND1	CTNNB1	ENSCHIP00000006815	ENSCHIP00000031016	Cyclin D1; Belongs to the cyclin family.	Catenin beta 1.	0.934
CCND1	DKK1	ENSCHIP00000006815	ENSCHIP00000013400	Cyclin D1; Belongs to the cyclin family.	Dickkopf WNT signaling pathway inhibitor 1.	0.676