(32 nodes) (2011) Atlas of Wnt and R-spondin gene expression in the developing male mouse lower urogenital tract. network (Capra hircus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	ACTA2	Actin alpha 2, smooth muscle. (377 aa)
	WNT8A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	WNT2B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (394 aa)
	WNT9A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (376 aa)
	WNT10B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	RSPO3	R-spondin 3. (303 aa)
	SFRP1	Secreted frizzled related protein 1. (308 aa)
	WNT5B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
	WNT7B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (416 aa)
	DKK1	Dickkopf WNT signaling pathway inhibitor 1. (262 aa)
	RSPO4	R-spondin 4. (232 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
	WNT16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
	WNT3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	RSPO2	R-spondin 2. (243 aa)
	AXIN2	Axin 2. (844 aa)
	AR	Androgen receptor. (891 aa)
	SOX9	SRY-box transcription factor 9. (525 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	WNT8B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (364 aa)
	WNT7A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
	WNT10A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (416 aa)
	WNT6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
	LEF1	HMG box domain-containing protein. (430 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	DKK2	Dickkopf WNT signaling pathway inhibitor 2. (259 aa)
	SRD5A2	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (254 aa)
	CTNNB1	Catenin beta 1. (781 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTA2	CTNNB1	ENSCHIP00000018506	ENSCHIP00000031016	Actin alpha 2, smooth muscle.	Catenin beta 1.	0.407
ACTA2	SOX9	ENSCHIP00000018506	ENSCHIP00000024523	Actin alpha 2, smooth muscle.	SRY-box transcription factor 9.	0.563
AR	CTNNB1	ENSCHIP00000024342	ENSCHIP00000031016	Androgen receptor.	Catenin beta 1.	0.943
AR	SOX9	ENSCHIP00000024342	ENSCHIP00000024523	Androgen receptor.	SRY-box transcription factor 9.	0.526
AR	SRD5A2	ENSCHIP00000024342	ENSCHIP00000031177	Androgen receptor.	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	0.627
AXIN2	CTNNB1	ENSCHIP00000022676	ENSCHIP00000031016	Axin 2.	Catenin beta 1.	0.998
AXIN2	DKK1	ENSCHIP00000022676	ENSCHIP00000013400	Axin 2.	Dickkopf WNT signaling pathway inhibitor 1.	0.901
AXIN2	DKK2	ENSCHIP00000022676	ENSCHIP00000031823	Axin 2.	Dickkopf WNT signaling pathway inhibitor 2.	0.679
AXIN2	FGF10	ENSCHIP00000022676	ENSCHIP00000010028	Axin 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.417
AXIN2	LEF1	ENSCHIP00000022676	ENSCHIP00000030629	Axin 2.	HMG box domain-containing protein.	0.955
AXIN2	RSPO2	ENSCHIP00000022676	ENSCHIP00000022352	Axin 2.	R-spondin 2.	0.588
AXIN2	RSPO3	ENSCHIP00000022676	ENSCHIP00000011558	Axin 2.	R-spondin 3.	0.547
AXIN2	RSPO4	ENSCHIP00000022676	ENSCHIP00000014527	Axin 2.	R-spondin 4.	0.418
AXIN2	SFRP1	ENSCHIP00000022676	ENSCHIP00000012579	Axin 2.	Secreted frizzled related protein 1.	0.789
AXIN2	SOX9	ENSCHIP00000022676	ENSCHIP00000024523	Axin 2.	SRY-box transcription factor 9.	0.731
AXIN2	WNT1	ENSCHIP00000022676	ENSCHIP00000020293	Axin 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.869
AXIN2	WNT10A	ENSCHIP00000022676	ENSCHIP00000026568	Axin 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.739
AXIN2	WNT10B	ENSCHIP00000022676	ENSCHIP00000007408	Axin 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.736
AXIN2	WNT11	ENSCHIP00000022676	ENSCHIP00000024696	Axin 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.772
AXIN2	WNT16	ENSCHIP00000022676	ENSCHIP00000015921	Axin 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.727