(14 nodes) (2011) Tfap2a and Foxd3 regulate early steps in the development of the neural crest progenitor population. network (Capra hircus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	FST	Uncharacterized protein. (344 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	LRP5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1615 aa)
	SOX10	SRY-box transcription factor 10. (469 aa)
	AXIN2	Axin 2. (844 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
	LRP6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
	DKK1	Dickkopf WNT signaling pathway inhibitor 1. (262 aa)
	CHRD	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (957 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AXIN2	BMP4	ENSCHIP00000022676	ENSCHIP00000023678	Axin 2.	Bone morphogenetic protein 4.	0.715
AXIN2	CTNNB1	ENSCHIP00000022676	ENSCHIP00000031016	Axin 2.	Catenin beta 1.	0.998
AXIN2	DKK1	ENSCHIP00000022676	ENSCHIP00000013400	Axin 2.	Dickkopf WNT signaling pathway inhibitor 1.	0.901
AXIN2	LRP5	ENSCHIP00000022676	ENSCHIP00000021146	Axin 2.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.946
AXIN2	LRP6	ENSCHIP00000022676	ENSCHIP00000013402	Axin 2.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.953
AXIN2	SHH	ENSCHIP00000022676	ENSCHIP00000027767	Axin 2.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.705
AXIN2	TP53	ENSCHIP00000022676	ENSCHIP00000030141	Axin 2.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.608
AXIN2	WNT1	ENSCHIP00000022676	ENSCHIP00000020293	Axin 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.869
AXIN2	WNT3A	ENSCHIP00000022676	ENSCHIP00000015590	Axin 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.924
AXIN2	WNT5A	ENSCHIP00000022676	ENSCHIP00000015533	Axin 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.893
BMP4	AXIN2	ENSCHIP00000023678	ENSCHIP00000022676	Bone morphogenetic protein 4.	Axin 2.	0.715
BMP4	CHRD	ENSCHIP00000023678	ENSCHIP00000008141	Bone morphogenetic protein 4.	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	0.995
BMP4	CTNNB1	ENSCHIP00000023678	ENSCHIP00000031016	Bone morphogenetic protein 4.	Catenin beta 1.	0.800
BMP4	DKK1	ENSCHIP00000023678	ENSCHIP00000013400	Bone morphogenetic protein 4.	Dickkopf WNT signaling pathway inhibitor 1.	0.733
BMP4	FST	ENSCHIP00000023678	ENSCHIP00000016699	Bone morphogenetic protein 4.	Uncharacterized protein.	0.878
BMP4	LRP5	ENSCHIP00000023678	ENSCHIP00000021146	Bone morphogenetic protein 4.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.503
BMP4	LRP6	ENSCHIP00000023678	ENSCHIP00000013402	Bone morphogenetic protein 4.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.466
BMP4	SHH	ENSCHIP00000023678	ENSCHIP00000027767	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.909
BMP4	SOX10	ENSCHIP00000023678	ENSCHIP00000022016	Bone morphogenetic protein 4.	SRY-box transcription factor 10.	0.606
BMP4	TP53	ENSCHIP00000023678	ENSCHIP00000030141	Bone morphogenetic protein 4.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.447