(12 nodes) (2012) RNA-binding protein Musashi1 modulates glioma cell growth through the post-transcriptional regulation of Notch and PI3 kinaseAkt signaling pathways. network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	EIF4G2	Eukaryotic translation initiation factor 4 gamma 2. (905 aa)
	NUMB	NUMB endocytic adaptor protein. (650 aa)
	CCNB1	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (427 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (900 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (275 aa)
	ACTB	Uncharacterized protein. (375 aa)
	CCND1	Cyclin D1; Belongs to the cyclin family. (295 aa)
	EIF4G1	Eukaryotic translation initiation factor 4 gamma 1. (1607 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (402 aa)
	NUMBL	NUMB like endocytic adaptor protein. (594 aa)
	EIF4G3	Eukaryotic translation initiation factor 4 gamma 3. (1584 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	CASP3	ENSCHIP00000011080	ENSCHIP00000011490	Uncharacterized protein.	Caspase 3; Belongs to the peptidase C14A family.	0.996
ACTB	CCNB1	ENSCHIP00000011080	ENSCHIP00000015792	Uncharacterized protein.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.869
ACTB	CCND1	ENSCHIP00000011080	ENSCHIP00000006815	Uncharacterized protein.	Cyclin D1; Belongs to the cyclin family.	0.890
ACTB	FGF2	ENSCHIP00000011080	ENSCHIP00000019134	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.763
ACTB	NUMB	ENSCHIP00000011080	ENSCHIP00000017697	Uncharacterized protein.	NUMB endocytic adaptor protein.	0.420
ACTB	NUMBL	ENSCHIP00000011080	ENSCHIP00000024865	Uncharacterized protein.	NUMB like endocytic adaptor protein.	0.439
ACTB	PTEN	ENSCHIP00000011080	ENSCHIP00000002897	Uncharacterized protein.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.844
CASP3	ACTB	ENSCHIP00000011490	ENSCHIP00000011080	Caspase 3; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.996
CASP3	CCNB1	ENSCHIP00000011490	ENSCHIP00000015792	Caspase 3; Belongs to the peptidase C14A family.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.871
CASP3	CCND1	ENSCHIP00000011490	ENSCHIP00000006815	Caspase 3; Belongs to the peptidase C14A family.	Cyclin D1; Belongs to the cyclin family.	0.891
CASP3	FGF2	ENSCHIP00000011490	ENSCHIP00000019134	Caspase 3; Belongs to the peptidase C14A family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.717
CASP3	PTEN	ENSCHIP00000011490	ENSCHIP00000002897	Caspase 3; Belongs to the peptidase C14A family.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.829
CCNB1	ACTB	ENSCHIP00000015792	ENSCHIP00000011080	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Uncharacterized protein.	0.869
CCNB1	CASP3	ENSCHIP00000015792	ENSCHIP00000011490	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Caspase 3; Belongs to the peptidase C14A family.	0.871
CCNB1	CCND1	ENSCHIP00000015792	ENSCHIP00000006815	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Cyclin D1; Belongs to the cyclin family.	0.702
CCNB1	PTEN	ENSCHIP00000015792	ENSCHIP00000002897	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.630
CCND1	ACTB	ENSCHIP00000006815	ENSCHIP00000011080	Cyclin D1; Belongs to the cyclin family.	Uncharacterized protein.	0.890
CCND1	CASP3	ENSCHIP00000006815	ENSCHIP00000011490	Cyclin D1; Belongs to the cyclin family.	Caspase 3; Belongs to the peptidase C14A family.	0.891
CCND1	CCNB1	ENSCHIP00000006815	ENSCHIP00000015792	Cyclin D1; Belongs to the cyclin family.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.702
CCND1	FGF2	ENSCHIP00000006815	ENSCHIP00000019134	Cyclin D1; Belongs to the cyclin family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.707