(23 nodes) (2012) Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue. network (Capra hircus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Your Input:
	TH	Tyrosine hydroxylase. (516 aa)
	ADIPOQ	C1q domain-containing protein. (283 aa)
	ALDH1A2	Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
	LOC106501717	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	ADRB1	Adrenoceptor beta 1. (467 aa)
	FABP4	Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
	UCP1	Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (305 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
	NRF1	Nuclear respiratory factor 1. (503 aa)
	ACTB	Uncharacterized protein. (375 aa)
	ADRB3	Beta-3 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta- 3 is involved in the regulation of lipolysis and thermogenesis. (430 aa)
	GLB1	Beta-galactosidase. (646 aa)
	TFAM	Transcription factor A, mitochondrial. (246 aa)
	RARA	Retinoic acid receptor alpha. (462 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
	CYP26A1	Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. (497 aa)
	ALDH1A3	Aldehyde dehydrogenase 1 family member A3; Belongs to the aldehyde dehydrogenase family. (512 aa)
	GLB1L3	Beta-galactosidase. (664 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	RBP4	Retinol-binding protein; Retinol-binding protein that mediates retinol transport in blood plasma. (203 aa)
	CIDEA	CIDE-N domain-containing protein. (219 aa)
	RXRA	NR LBD domain-containing protein. (106 aa)
	LOC102173997	Capra hircus breed Kapro cytochrome c mRNA; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ADIPOQ	ENSCHIP00000011080	ENSCHIP00000032803	Uncharacterized protein.	C1q domain-containing protein.	0.751
ACTB	CIDEA	ENSCHIP00000011080	ENSCHIP00000028243	Uncharacterized protein.	CIDE-N domain-containing protein.	0.430
ACTB	FABP4	ENSCHIP00000011080	ENSCHIP00000004118	Uncharacterized protein.	Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	0.656
ACTB	GAPDH	ENSCHIP00000011080	ENSCHIP00000025974	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.979
ACTB	INS	ENSCHIP00000011080	ENSCHIP00000007610	Uncharacterized protein.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.884
ACTB	LOC102173997	ENSCHIP00000011080	ENSCHIP00000031546	Uncharacterized protein.	Capra hircus breed Kapro cytochrome c mRNA; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.884
ACTB	LOC106501717	ENSCHIP00000011080	ENSCHIP00000032023	Uncharacterized protein.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.884
ACTB	NRF1	ENSCHIP00000011080	ENSCHIP00000008463	Uncharacterized protein.	Nuclear respiratory factor 1.	0.564
ACTB	PPARG	ENSCHIP00000011080	ENSCHIP00000015163	Uncharacterized protein.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.984
ACTB	RXRA	ENSCHIP00000011080	ENSCHIP00000028697	Uncharacterized protein.	NR LBD domain-containing protein.	0.400
ACTB	TFAM	ENSCHIP00000011080	ENSCHIP00000013167	Uncharacterized protein.	Transcription factor A, mitochondrial.	0.770
ACTB	TH	ENSCHIP00000011080	ENSCHIP00000032072	Uncharacterized protein.	Tyrosine hydroxylase.	0.760
ACTB	UCP1	ENSCHIP00000011080	ENSCHIP00000007597	Uncharacterized protein.	Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.722
ADIPOQ	ACTB	ENSCHIP00000032803	ENSCHIP00000011080	C1q domain-containing protein.	Uncharacterized protein.	0.751
ADIPOQ	ADRB3	ENSCHIP00000032803	ENSCHIP00000011884	C1q domain-containing protein.	Beta-3 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta- 3 is involved in the regulation of lipolysis and thermogenesis.	0.706
ADIPOQ	CIDEA	ENSCHIP00000032803	ENSCHIP00000028243	C1q domain-containing protein.	CIDE-N domain-containing protein.	0.754
ADIPOQ	FABP4	ENSCHIP00000032803	ENSCHIP00000004118	C1q domain-containing protein.	Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	0.983
ADIPOQ	GAPDH	ENSCHIP00000032803	ENSCHIP00000025974	C1q domain-containing protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.719
ADIPOQ	INS	ENSCHIP00000032803	ENSCHIP00000007610	C1q domain-containing protein.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.920
ADIPOQ	PPARG	ENSCHIP00000032803	ENSCHIP00000015163	C1q domain-containing protein.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.920