(23 nodes) (2012) Coaggregation of RNA-binding proteins in a model of TDP-43 proteinopathy with selective RGG motif methylation and a role for RRM1 ubiquitination. network (Capra hircus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	SUMO2	Small ubiquitin-related modifier. (95 aa)
	PABPC1	Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (636 aa)
	CCL2	C-C motif chemokine. (98 aa)
	CCT7	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. (543 aa)
	EIF4A1	Eukaryotic translation initiation factor 4A1; Belongs to the DEAD box helicase family. (406 aa)
	RBM14	RNA binding motif protein 14. (669 aa)
	KHDRBS1	KH RNA binding domain containing, signal transduction associated 1. (443 aa)
	PA2G4	Peptidase_M24 domain-containing protein. (394 aa)
	SNCA	Alpha-synuclein; Belongs to the synuclein family. (140 aa)
	EIF4G1	Eukaryotic translation initiation factor 4 gamma 1. (1607 aa)
	PRMT2	Protein arginine methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (434 aa)
	NONO	Non-POU domain containing octamer binding. (470 aa)
	CANX	Calnexin. (593 aa)
	HNRNPA0	Heterogeneous nuclear ribonucleoprotein A0. (304 aa)
	HNRNPU	Heterogeneous nuclear ribonucleoprotein U. (806 aa)
	USP14	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (494 aa)
	NEDD8	NEDD8 ubiquitin like modifier. (77 aa)
	RRM1	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (791 aa)
	ALYREF	Aly/REF export factor. (267 aa)
	ISG15	Interferon-stimulated protein 17/ubiquitin cross-reactive protein. (157 aa)
	LOC102176111	Triosephosphate isomerase. (201 aa)
	TPI1	Triosephosphate isomerase. (295 aa)
	UBC	Ubiquitin C. (655 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALYREF	CCT7	ENSCHIP00000017673	ENSCHIP00000026590	Aly/REF export factor.	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.	0.447
ALYREF	EIF4A1	ENSCHIP00000017673	ENSCHIP00000025335	Aly/REF export factor.	Eukaryotic translation initiation factor 4A1; Belongs to the DEAD box helicase family.	0.569
ALYREF	EIF4G1	ENSCHIP00000017673	ENSCHIP00000005945	Aly/REF export factor.	Eukaryotic translation initiation factor 4 gamma 1.	0.477
ALYREF	HNRNPA0	ENSCHIP00000017673	ENSCHIP00000001329	Aly/REF export factor.	Heterogeneous nuclear ribonucleoprotein A0.	0.559
ALYREF	HNRNPU	ENSCHIP00000017673	ENSCHIP00000002234	Aly/REF export factor.	Heterogeneous nuclear ribonucleoprotein U.	0.499
ALYREF	NONO	ENSCHIP00000017673	ENSCHIP00000000521	Aly/REF export factor.	Non-POU domain containing octamer binding.	0.493
ALYREF	PABPC1	ENSCHIP00000017673	ENSCHIP00000028120	Aly/REF export factor.	Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family.	0.461
ALYREF	RBM14	ENSCHIP00000017673	ENSCHIP00000023332	Aly/REF export factor.	RNA binding motif protein 14.	0.542
CANX	SNCA	ENSCHIP00000000791	ENSCHIP00000009503	Calnexin.	Alpha-synuclein; Belongs to the synuclein family.	0.441
CCL2	ISG15	ENSCHIP00000027804	ENSCHIP00000017154	C-C motif chemokine.	Interferon-stimulated protein 17/ubiquitin cross-reactive protein.	0.668
CCT7	ALYREF	ENSCHIP00000026590	ENSCHIP00000017673	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.	Aly/REF export factor.	0.447
CCT7	PA2G4	ENSCHIP00000026590	ENSCHIP00000005047	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.	Peptidase_M24 domain-containing protein.	0.482
EIF4A1	ALYREF	ENSCHIP00000025335	ENSCHIP00000017673	Eukaryotic translation initiation factor 4A1; Belongs to the DEAD box helicase family.	Aly/REF export factor.	0.569
EIF4A1	EIF4G1	ENSCHIP00000025335	ENSCHIP00000005945	Eukaryotic translation initiation factor 4A1; Belongs to the DEAD box helicase family.	Eukaryotic translation initiation factor 4 gamma 1.	0.995
EIF4A1	HNRNPA0	ENSCHIP00000025335	ENSCHIP00000001329	Eukaryotic translation initiation factor 4A1; Belongs to the DEAD box helicase family.	Heterogeneous nuclear ribonucleoprotein A0.	0.445
EIF4A1	HNRNPU	ENSCHIP00000025335	ENSCHIP00000002234	Eukaryotic translation initiation factor 4A1; Belongs to the DEAD box helicase family.	Heterogeneous nuclear ribonucleoprotein U.	0.484
EIF4A1	PA2G4	ENSCHIP00000025335	ENSCHIP00000005047	Eukaryotic translation initiation factor 4A1; Belongs to the DEAD box helicase family.	Peptidase_M24 domain-containing protein.	0.409
EIF4A1	PABPC1	ENSCHIP00000025335	ENSCHIP00000028120	Eukaryotic translation initiation factor 4A1; Belongs to the DEAD box helicase family.	Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family.	0.875
EIF4G1	ALYREF	ENSCHIP00000005945	ENSCHIP00000017673	Eukaryotic translation initiation factor 4 gamma 1.	Aly/REF export factor.	0.477
EIF4G1	EIF4A1	ENSCHIP00000005945	ENSCHIP00000025335	Eukaryotic translation initiation factor 4 gamma 1.	Eukaryotic translation initiation factor 4A1; Belongs to the DEAD box helicase family.	0.995