(8 nodes) (2012) Systemic shRNA mediated knock down of S100A4 in colorectal cancer xenografted mice reduces metastasis formation. network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PXDN	Peroxidasin. (1525 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	SP3	Sp3 transcription factor. (778 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
	S100A4	Protein S100; Belongs to the S-100 family. (101 aa)
	CTNNB1	Catenin beta 1. (781 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTNNB1	GAPDH	ENSCHIP00000031016	ENSCHIP00000025974	Catenin beta 1.	Glyceraldehyde-3-phosphate dehydrogenase.	0.940
CTNNB1	PXDN	ENSCHIP00000031016	ENSCHIP00000015493	Catenin beta 1.	Peroxidasin.	0.877
CTNNB1	S100A4	ENSCHIP00000031016	ENSCHIP00000030714	Catenin beta 1.	Protein S100; Belongs to the S-100 family.	0.563
CTNNB1	SMAD3	ENSCHIP00000031016	ENSCHIP00000011729	Catenin beta 1.	Mothers against decapentaplegic homolog.	0.932
CTNNB1	TGFB1	ENSCHIP00000031016	ENSCHIP00000008885	Catenin beta 1.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.753
CTNNB1	TP53	ENSCHIP00000031016	ENSCHIP00000030141	Catenin beta 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.892
GAPDH	CTNNB1	ENSCHIP00000025974	ENSCHIP00000031016	Glyceraldehyde-3-phosphate dehydrogenase.	Catenin beta 1.	0.940
GAPDH	PXDN	ENSCHIP00000025974	ENSCHIP00000015493	Glyceraldehyde-3-phosphate dehydrogenase.	Peroxidasin.	0.974
GAPDH	S100A4	ENSCHIP00000025974	ENSCHIP00000030714	Glyceraldehyde-3-phosphate dehydrogenase.	Protein S100; Belongs to the S-100 family.	0.573
GAPDH	SMAD3	ENSCHIP00000025974	ENSCHIP00000011729	Glyceraldehyde-3-phosphate dehydrogenase.	Mothers against decapentaplegic homolog.	0.895
GAPDH	SP3	ENSCHIP00000025974	ENSCHIP00000029194	Glyceraldehyde-3-phosphate dehydrogenase.	Sp3 transcription factor.	0.483
GAPDH	TGFB1	ENSCHIP00000025974	ENSCHIP00000008885	Glyceraldehyde-3-phosphate dehydrogenase.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.860
GAPDH	TP53	ENSCHIP00000025974	ENSCHIP00000030141	Glyceraldehyde-3-phosphate dehydrogenase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.902
PXDN	CTNNB1	ENSCHIP00000015493	ENSCHIP00000031016	Peroxidasin.	Catenin beta 1.	0.877
PXDN	GAPDH	ENSCHIP00000015493	ENSCHIP00000025974	Peroxidasin.	Glyceraldehyde-3-phosphate dehydrogenase.	0.974
PXDN	S100A4	ENSCHIP00000015493	ENSCHIP00000030714	Peroxidasin.	Protein S100; Belongs to the S-100 family.	0.428
PXDN	SMAD3	ENSCHIP00000015493	ENSCHIP00000011729	Peroxidasin.	Mothers against decapentaplegic homolog.	0.781
PXDN	TGFB1	ENSCHIP00000015493	ENSCHIP00000008885	Peroxidasin.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.742
PXDN	TP53	ENSCHIP00000015493	ENSCHIP00000030141	Peroxidasin.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.893
S100A4	CTNNB1	ENSCHIP00000030714	ENSCHIP00000031016	Protein S100; Belongs to the S-100 family.	Catenin beta 1.	0.563