16 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CSF1	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (554 aa)
	BGLAP	Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. (97 aa)
	COL1A2	Collagen type I alpha 2 chain. (1128 aa)
	PDIA3	Protein disulfide-isomerase. (505 aa)
	TNFRSF11B	Tumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (402 aa)
	XBP1	BZIP domain-containing protein. (261 aa)
	COL1A1	Collagen type I alpha 1 chain. (1463 aa)
	SPARC	Osteonectin. (303 aa)
	CRTAP	Cartilage associated protein. (404 aa)
	MMP9	Uncharacterized protein. (709 aa)
	RACK1	Receptor for activated C kinase 1. (317 aa)
	ACTB	Uncharacterized protein. (375 aa)
	TIMP1	NTR domain-containing protein. (207 aa)
	SERPINH1	Serpin family H member 1; Belongs to the serpin family. (418 aa)
	P3H3	Prolyl 3-hydroxylase 3. (727 aa)
	ERP44	Endoplasmic reticulum protein 44. (406 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	BGLAP	ENSCHIP00000011080	ENSCHIP00000031297	Uncharacterized protein.	Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.	0.696
ACTB	COL1A1	ENSCHIP00000011080	ENSCHIP00000023918	Uncharacterized protein.	Collagen type I alpha 1 chain.	0.776
ACTB	COL1A2	ENSCHIP00000011080	ENSCHIP00000031191	Uncharacterized protein.	Collagen type I alpha 2 chain.	0.563
ACTB	CSF1	ENSCHIP00000011080	ENSCHIP00000033660	Uncharacterized protein.	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	0.729
ACTB	MMP9	ENSCHIP00000011080	ENSCHIP00000016938	Uncharacterized protein.	Uncharacterized protein.	0.881
ACTB	PDIA3	ENSCHIP00000011080	ENSCHIP00000029698	Uncharacterized protein.	Protein disulfide-isomerase.	0.524
ACTB	RACK1	ENSCHIP00000011080	ENSCHIP00000014661	Uncharacterized protein.	Receptor for activated C kinase 1.	0.490
ACTB	SPARC	ENSCHIP00000011080	ENSCHIP00000023372	Uncharacterized protein.	Osteonectin.	0.437
ACTB	TIMP1	ENSCHIP00000011080	ENSCHIP00000006216	Uncharacterized protein.	NTR domain-containing protein.	0.567
ACTB	XBP1	ENSCHIP00000011080	ENSCHIP00000027960	Uncharacterized protein.	BZIP domain-containing protein.	0.770
BGLAP	ACTB	ENSCHIP00000031297	ENSCHIP00000011080	Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.	Uncharacterized protein.	0.696
BGLAP	COL1A1	ENSCHIP00000031297	ENSCHIP00000023918	Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.	Collagen type I alpha 1 chain.	0.837
BGLAP	COL1A2	ENSCHIP00000031297	ENSCHIP00000031191	Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.	Collagen type I alpha 2 chain.	0.582
BGLAP	CSF1	ENSCHIP00000031297	ENSCHIP00000033660	Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	0.442
BGLAP	MMP9	ENSCHIP00000031297	ENSCHIP00000016938	Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.	Uncharacterized protein.	0.526
BGLAP	SPARC	ENSCHIP00000031297	ENSCHIP00000023372	Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.	Osteonectin.	0.951
BGLAP	TNFRSF11B	ENSCHIP00000031297	ENSCHIP00000029638	Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.	Tumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis.	0.515
COL1A1	ACTB	ENSCHIP00000023918	ENSCHIP00000011080	Collagen type I alpha 1 chain.	Uncharacterized protein.	0.776
COL1A1	BGLAP	ENSCHIP00000023918	ENSCHIP00000031297	Collagen type I alpha 1 chain.	Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.	0.837
COL1A1	COL1A2	ENSCHIP00000023918	ENSCHIP00000031191	Collagen type I alpha 1 chain.	Collagen type I alpha 2 chain.	0.999