STRINGSTRING
CD63 CD63 YWHAQ YWHAQ ENSCHIP00000009938 ENSCHIP00000009938 RAB5C RAB5C ITGA6 ITGA6 DPEP1 DPEP1 ACTB ACTB TSG101 TSG101 MYO1B MYO1B RALA RALA MFGE8 MFGE8 FSCN1 FSCN1 CAPZA2 CAPZA2 LCK LCK PTK2 PTK2 LOC100861197 LOC100861197 YBX1 YBX1 ITGA5 ITGA5 PKP2 PKP2 ITGA3 ITGA3 PAK4 PAK4 MACC1 MACC1 SLC2A1 SLC2A1 CASK CASK AARS1 AARS1 YWHAB YWHAB ACTR3 ACTR3 ICAM1 ICAM1 ENO1 ENO1 PKM PKM YWHAH YWHAH PXDN PXDN DSG2 DSG2 ANXA6 ANXA6 ITGB5 ITGB5 TCP1 TCP1 S100A14 S100A14 HSPA8 HSPA8 ILK ILK ATP1A1 ATP1A1 CORO1B CORO1B VPS37B VPS37B SDCBP SDCBP NME1 NME1 SLC3A2 SLC3A2 PTGFRN PTGFRN VCP VCP PKP4 PKP4 FASN FASN MYH10 MYH10 KRT8 KRT8 AARS2 AARS2 RALB RALB CCDC50 CCDC50 SCRIB SCRIB ARF3 ARF3 MYH9 MYH9 CNN1 CNN1 PTK7 PTK7 CD276 CD276 HSPA9 HSPA9 VPS28 VPS28 YWHAZ YWHAZ ENSCHIP00000022284 ENSCHIP00000022284 VIM VIM EGFR EGFR S100A6 S100A6 CHMP4A CHMP4A FMNL1 FMNL1 ANXA1 ANXA1 SLC1A5 SLC1A5 ARPC1B ARPC1B ANXA13 ANXA13 LGALS3BP LGALS3BP ITGA1 ITGA1 CD44 CD44 CACYBP CACYBP ANXA5 ANXA5 STRAP STRAP CNN3 CNN3 HNRNPD HNRNPD HSP90AA1 HSP90AA1 LIMS1 LIMS1 GAPDH GAPDH MIF MIF EPCAM EPCAM CNN2 CNN2 YWHAE YWHAE LOC108634039 LOC108634039 MYO10 MYO10 AK2 AK2 ANXA9 ANXA9 CAPZB CAPZB CTNND1 CTNND1 CFL1 CFL1 DYNC1H1 DYNC1H1 UGDH UGDH KRT10 KRT10 EHD4 EHD4 S100A4 S100A4 YWHAG YWHAG TUBB TUBB VPS35 VPS35 PFN1 PFN1 PPFIBP1 PPFIBP1 PROM1 PROM1 JUP JUP CHMP5 CHMP5 ITGA2 ITGA2 SDCBP2 SDCBP2 AHCY AHCY KRT1 KRT1 FMNL2 FMNL2 ANXA4 ANXA4 SLC12A2 SLC12A2 PDCD6IP PDCD6IP TAGLN2 TAGLN2 LOC102176495 LOC102176495 L1CAM L1CAM ANXA11 ANXA11 ANXA7 ANXA7 LAMP1 LAMP1 RAB7A RAB7A LOC102190442 LOC102190442 TPBG TPBG HSPD1 HSPD1 TGFBI TGFBI CTNNA1 CTNNA1 ANXA2 ANXA2 CPNE3 CPNE3 CHMP4C CHMP4C ITGB4 ITGB4 MYL6B MYL6B ADAM10 ADAM10 ARPC2 ARPC2 LCP1 LCP1 RAB10 RAB10 PDCD6 PDCD6 CD9 CD9 PA2G4 PA2G4 MARCKS MARCKS SLC44A1 SLC44A1 ABCC4 ABCC4 CD81 CD81 PGK1 PGK1 ITGAV ITGAV IQGAP1 IQGAP1 DLG1 DLG1 ATP5F1B ATP5F1B ABCC1 ABCC1 ITGB1 ITGB1 CHMP2A CHMP2A LOC102168811 LOC102168811 CDH13 CDH13 VPS4A VPS4A PKP3 PKP3 ANXA3 ANXA3 DDX5 DDX5 STXBP3 STXBP3 SYK SYK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CD63Tetraspanin. (237 aa)
YWHAQ14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (245 aa)
ENSCHIP00000009938Annexin. (100 aa)
RAB5CUncharacterized protein. (216 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1072 aa)
DPEP1Dipeptidase; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (410 aa)
ACTBUncharacterized protein. (375 aa)
TSG101Uncharacterized protein. (391 aa)
MYO1BMyosin IB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1140 aa)
RALARAS like proto-oncogene A. (206 aa)
MFGE8Lactadherin. (430 aa)
FSCN1Fascin. (493 aa)
CAPZA2F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (286 aa)
LCKTyrosine-protein kinase. (509 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1095 aa)
LOC100861197Glutathione S-transferase P; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration (By similarity); Belongs to the GST superfamily. Pi family. (210 aa)
YBX1CSD_1 domain-containing protein. (324 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1100 aa)
PKP2Plakophilin 2. (851 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1064 aa)
PAK4Non-specific serine/threonine protein kinase. (584 aa)
MACC1MET transcriptional regulator MACC1. (852 aa)
SLC2A1MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (500 aa)
CASKCalcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (926 aa)
AARS1Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (968 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
ACTR3Uncharacterized protein; Belongs to the actin family. (405 aa)
ICAM1Intercellular adhesion molecule 1. (532 aa)
ENO1Enolase 1. (434 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (531 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa)
PXDNPeroxidasin. (1525 aa)
DSG2Desmoglein 2. (1119 aa)
ANXA6Annexin. (689 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (802 aa)
TCP1T-complex 1. (556 aa)
S100A14S100 calcium binding protein A14; Belongs to the S-100 family. (104 aa)
HSPA8Uncharacterized protein; Belongs to the heat shock protein 70 family. (646 aa)
ILKIntegrin linked kinase. (452 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1028 aa)
CORO1BCoronin; Belongs to the WD repeat coronin family. (488 aa)
VPS37BVPS37B subunit of ESCRT-I. (289 aa)
SDCBPSyndecan binding protein. (359 aa)
NME1Nucleoside diphosphate kinase. (157 aa)
SLC3A2Solute carrier family 3 member 2. (577 aa)
PTGFRNProstaglandin F2 receptor inhibitor. (879 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (816 aa)
PKP4Plakophilin 4. (1193 aa)
FASNFatty acid synthase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. (2755 aa)
MYH10Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1975 aa)
KRT8Keratin 8; Belongs to the intermediate filament family. (484 aa)
AARS2Alanyl-tRNA synthetase 2, mitochondrial; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (983 aa)
RALBRAS like proto-oncogene B. (206 aa)
CCDC50Coiled-coil domain containing 50. (481 aa)
SCRIBScribble planar cell polarity protein. (1582 aa)
ARF3ADP ribosylation factor 3; Belongs to the small GTPase superfamily. Arf family. (181 aa)
MYH9Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1986 aa)
CNN1Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (297 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa)
CD276CD276 molecule. (533 aa)
HSPA9Heat shock protein family A (Hsp70) member 9; Belongs to the heat shock protein 70 family. (679 aa)
VPS28Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. (221 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide; Belongs to the 14-3-3 family. (245 aa)
ENSCHIP00000022284Annexin. (275 aa)
VIMVimentin; Belongs to the intermediate filament family. (471 aa)
EGFRReceptor protein-tyrosine kinase. (1208 aa)
S100A6S100 calcium binding protein A6; Belongs to the S-100 family. (80 aa)
CHMP4ACharged multivesicular body protein 4A. (222 aa)
FMNL1Formin like 1. (1121 aa)
ANXA1Annexin. (346 aa)
SLC1A5Amino acid transporter. (530 aa)
ARPC1BActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (372 aa)
ANXA13Annexin. (371 aa)
LGALS3BPGalectin 3 binding protein. (553 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1179 aa)
CD44CD44 molecule (Indian blood group). (715 aa)
CACYBPCalcyclin binding protein. (230 aa)
ANXA5Annexin. (334 aa)
STRAPSerine/threonine kinase receptor associated protein. (350 aa)
CNN3Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (329 aa)
HNRNPDHeterogeneous nuclear ribonucleoprotein D. (355 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (733 aa)
LIMS1LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. (336 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
MIFMacrophage migration inhibitory factor. (115 aa)
EPCAMEpithelial cell adhesion molecule. (314 aa)
CNN2Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (309 aa)
YWHAE14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (243 aa)
LOC108634039Annexin. (449 aa)
MYO10Myosin X; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2040 aa)
AK2Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. (241 aa)
ANXA9Annexin. (345 aa)
CAPZBF-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (110 aa)
CTNND1Catenin delta 1. (939 aa)
CFL1Cofilin 1; Belongs to the actin-binding proteins ADF family. (165 aa)
DYNC1H1Dynein cytoplasmic 1 heavy chain 1. (4641 aa)
UGDHUDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (494 aa)
KRT10Keratin 10; Belongs to the intermediate filament family. (564 aa)
EHD4EH domain containing 4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (540 aa)
S100A4Protein S100; Belongs to the S-100 family. (101 aa)
YWHAGTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (247 aa)
TUBBTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (444 aa)
VPS35Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (796 aa)
PFN1Profilin; Belongs to the profilin family. (140 aa)
PPFIBP1PPFIA binding protein 1. (1033 aa)
PROM1Prominin 1. (855 aa)
JUPJunction plakoglobin. (745 aa)
CHMP5Charged multivesicular body protein 5. (219 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1179 aa)
SDCBP2Syndecan binding protein 2. (292 aa)
AHCYAdenosylhomocysteinase; Belongs to the adenosylhomocysteinase family. (432 aa)
KRT1Keratin 1; Belongs to the intermediate filament family. (614 aa)
FMNL2Formin like 2. (1093 aa)
ANXA4Annexin. (320 aa)
SLC12A2Solute carrier family 12 member 2. (1202 aa)
PDCD6IPBRO1 domain-containing protein. (880 aa)
TAGLN2Transgelin; Belongs to the calponin family. (199 aa)
LOC102176495Annexin. (331 aa)
L1CAML1 cell adhesion molecule. (1257 aa)
ANXA11Annexin. (503 aa)
ANXA7Annexin. (485 aa)
LAMP1Lysosomal associated membrane protein 1. (409 aa)
RAB7AUncharacterized protein. (207 aa)
LOC102190442Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (270 aa)
TPBGTrophoblast glycoprotein. (420 aa)
HSPD1Heat shock protein family D (Hsp60) member 1; Belongs to the chaperonin (HSP60) family. (573 aa)
TGFBITransforming growth factor beta induced. (683 aa)
CTNNA1Catenin alpha 1. (1018 aa)
ANXA2Annexin. (339 aa)
CPNE3Copine 3. (533 aa)
CHMP4CCharged multivesicular body protein 4C. (236 aa)
ITGB4Integrin beta. (1850 aa)
MYL6BMyosin light chain 6B. (211 aa)
ADAM10ADAM metallopeptidase domain 10. (750 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (303 aa)
LCP1Lymphocyte cytosolic protein 1. (627 aa)
RAB10RAB10, member RAS oncogene family. (200 aa)
PDCD6Uncharacterized protein. (185 aa)
CD9Tetraspanin. (226 aa)
PA2G4Peptidase_M24 domain-containing protein. (394 aa)
MARCKSMyristoylated alanine rich protein kinase C substrate. (333 aa)
SLC44A1Solute carrier family 44 member 1; Belongs to the CTL (choline transporter-like) family. (717 aa)
ABCC4Uncharacterized protein. (1323 aa)
CD81Tetraspanin. (236 aa)
PGK1Phosphoglycerate kinase. (424 aa)
ITGAVIntegrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1048 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1657 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (927 aa)
ATP5F1BATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (528 aa)
ABCC1ATP binding cassette subfamily C member 1. (1595 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
CHMP2ACharged multivesicular body protein 2A. (222 aa)
LOC102168811Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (289 aa)
CDH13Cadherin 13. (663 aa)
VPS4AUncharacterized protein; Belongs to the AAA ATPase family. (442 aa)
PKP3Uncharacterized protein. (412 aa)
ANXA3Annexin. (323 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (622 aa)
STXBP3Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (593 aa)
SYKSpleen associated tyrosine kinase. (636 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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