STRINGSTRING
AFP AFP MMP12 MMP12 PROM1 PROM1 HGFAC HGFAC LAMB1 LAMB1 ITGA7 ITGA7 TGFB2 TGFB2 COL14A1 COL14A1 COL9A3 COL9A3 PLAU PLAU TGFB3 TGFB3 GJA1 GJA1 ITGB4 ITGB4 AGRN AGRN BGN BGN HGF HGF TIMP1 TIMP1 KLKB1 KLKB1 ITGB1 ITGB1 LAMA5 LAMA5 ENSCHIP00000007600 ENSCHIP00000007600 MMP14 MMP14 PLG PLG TGFB1 TGFB1 COL5A2 COL5A2 ITGB6 ITGB6 ITGB2 ITGB2 LOC100861197 LOC100861197 CD24 CD24 MMP2 MMP2 COL8A1 COL8A1 MMP9 MMP9 DCN DCN DLK1 DLK1 COL6A3 COL6A3 PRSS8 PRSS8 NID2 NID2 ITGA4 ITGA4 VIM VIM MMP19 MMP19 NID1 NID1 SPARC SPARC COL1A1 COL1A1 FBN1 FBN1 COL4A1 COL4A1 SPINT1 SPINT1 CCN2 CCN2 HPN HPN COL1A2 COL1A2 COL16A1 COL16A1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AFPAlpha fetoprotein. (610 aa)
MMP12Matrix metallopeptidase 12. (470 aa)
PROM1Prominin 1. (855 aa)
HGFACHGF activator. (640 aa)
LAMB1Laminin subunit beta 1. (1842 aa)
ITGA7Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1181 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
COL14A1Collagen type XIV alpha 1 chain. (1775 aa)
COL9A3Uncharacterized protein. (392 aa)
PLAUPlasminogen activator, urokinase. (440 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
GJA1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
ITGB4Integrin beta. (1850 aa)
AGRNAgrin. (2041 aa)
BGNBiglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (373 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (814 aa)
TIMP1NTR domain-containing protein. (207 aa)
KLKB1Kallikrein B1; Belongs to the peptidase S1 family. (636 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
LAMA5Laminin subunit alpha 5. (2263 aa)
ENSCHIP00000007600Uncharacterized protein. (352 aa)
MMP14ZnMc domain-containing protein. (584 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (816 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
COL5A2Collagen type V alpha 2 chain. (1252 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (844 aa)
ITGB2Integrin beta-2; Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor [...] (774 aa)
LOC100861197Glutathione S-transferase P; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration (By similarity); Belongs to the GST superfamily. Pi family. (210 aa)
CD24Uncharacterized protein. (78 aa)
MMP2Matrix metallopeptidase 2. (661 aa)
COL8A1Collagen type VIII alpha 1 chain. (745 aa)
MMP9Uncharacterized protein. (709 aa)
DCNDecorin; May affect the rate of fibrils formation. (360 aa)
DLK1Uncharacterized protein. (380 aa)
COL6A3Collagen type VI alpha 3 chain. (3111 aa)
PRSS8Serine protease 8; Belongs to the peptidase S1 family. (343 aa)
NID2Nidogen 2. (1305 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1033 aa)
VIMVimentin; Belongs to the intermediate filament family. (471 aa)
MMP19Matrix metallopeptidase 19. (520 aa)
NID1Nidogen 1. (1252 aa)
SPARCOsteonectin. (303 aa)
COL1A1Collagen type I alpha 1 chain. (1463 aa)
FBN1Fibrillin 1. (2860 aa)
COL4A1Collagen type IV alpha 1 chain. (1608 aa)
SPINT1Serine peptidase inhibitor, Kunitz type 1. (508 aa)
CCN2Cellular communication network factor 2. (349 aa)
HPNHepsin; Belongs to the peptidase S1 family. (417 aa)
COL1A2Collagen type I alpha 2 chain. (1128 aa)
COL16A1Collagen type XVI alpha 1 chain. (1414 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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