(4 nodes) (2013) Benidipine protects kidney through inhibiting ROCK1 activity and reducing the epithelium-mesenchymal transdifferentiation in type 1 diabetic rats. network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RHOA	Ras-like protein family member A. (193 aa)
	PXDN	Peroxidasin. (1525 aa)
	ROCK1	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
	ACTB	Uncharacterized protein. (375 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	PXDN	ENSCHIP00000011080	ENSCHIP00000015493	Uncharacterized protein.	Peroxidasin.	0.962
ACTB	RHOA	ENSCHIP00000011080	ENSCHIP00000011951	Uncharacterized protein.	Ras-like protein family member A.	0.986
ACTB	ROCK1	ENSCHIP00000011080	ENSCHIP00000015667	Uncharacterized protein.	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	0.726
PXDN	ACTB	ENSCHIP00000015493	ENSCHIP00000011080	Peroxidasin.	Uncharacterized protein.	0.962
PXDN	RHOA	ENSCHIP00000015493	ENSCHIP00000011951	Peroxidasin.	Ras-like protein family member A.	0.764
PXDN	ROCK1	ENSCHIP00000015493	ENSCHIP00000015667	Peroxidasin.	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	0.658
RHOA	ACTB	ENSCHIP00000011951	ENSCHIP00000011080	Ras-like protein family member A.	Uncharacterized protein.	0.986
RHOA	PXDN	ENSCHIP00000011951	ENSCHIP00000015493	Ras-like protein family member A.	Peroxidasin.	0.764
RHOA	ROCK1	ENSCHIP00000011951	ENSCHIP00000015667	Ras-like protein family member A.	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	0.999
ROCK1	ACTB	ENSCHIP00000015667	ENSCHIP00000011080	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	Uncharacterized protein.	0.726
ROCK1	PXDN	ENSCHIP00000015667	ENSCHIP00000015493	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	Peroxidasin.	0.658
ROCK1	RHOA	ENSCHIP00000015667	ENSCHIP00000011951	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	Ras-like protein family member A.	0.999