STRINGSTRING
CSF2 CSF2 CSF1 CSF1 ACVRL1 ACVRL1 CSF1R CSF1R MST1R MST1R AATK AATK HOXB4 HOXB4 EPHA4 EPHA4 MPL MPL PDGFRB PDGFRB MERTK MERTK MRC1 MRC1 CD19 CD19 EPHA8 EPHA8 NTRK2 NTRK2 ACVR1 ACVR1 GAPDH GAPDH EPHA6 EPHA6 LYN LYN DDR2 DDR2 HCK HCK ABL1 ABL1 EPHB4 EPHB4 CD44 CD44 EPHA1 EPHA1 BTK BTK BMX BMX IL7R IL7R CXCR5 CXCR5 EPHA7 EPHA7 EGFR EGFR AXL AXL OSM OSM FLT1 FLT1 IL3RA IL3RA CCR7 CCR7 NGFR NGFR FGFR2 FGFR2 IL11 IL11 ROS1 ROS1 CD86 CD86 ANGPT1 ANGPT1 GAS6 GAS6 EPHA2 EPHA2 EPHA3 EPHA3 FGR FGR CXCL10 CXCL10 CXCR3 CXCR3 SPP1 SPP1 MATK MATK LIFR LIFR TYRO3 TYRO3 INSR INSR SRMS SRMS LCK LCK TIE1 TIE1 TXK TXK IL7 IL7 TNFRSF1A TNFRSF1A JAK1 JAK1 TNK2 TNK2 ZAP70 ZAP70 IL6 IL6 TGFB1 TGFB1 CSF2RB CSF2RB EDNRB EDNRB IL1A IL1A INS INS FGFR1 FGFR1 CD4 CD4 CD80 CD80 OSMR OSMR JAK3 JAK3 FYN FYN TNK1 TNK1 EPOR EPOR NGF NGF FGFR3 FGFR3 KDR KDR CCR8 CCR8 FRK FRK CSF3R CSF3R FLT3 FLT3 CD34 CD34 SRC SRC EPHB3 EPHB3 PDGFRA PDGFRA JAK2 JAK2 LOC102179993 LOC102179993 BMPR1A BMPR1A CSF2RA CSF2RA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CSF2Granulocyte-macrophage colony stimulating factor. (144 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (554 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
CSF1RColony stimulating factor 1 receptor. (958 aa)
MST1RMacrophage stimulating 1 receptor. (1401 aa)
AATKApoptosis associated tyrosine kinase. (1433 aa)
HOXB4Homeobox B4. (251 aa)
EPHA4EPH receptor A4. (986 aa)
MPLMPL proto-oncogene, thrombopoietin receptor. (643 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
MERTKMER proto-oncogene, tyrosine kinase. (992 aa)
MRC1Mannose receptor C-type 1. (1455 aa)
CD19CD19 molecule. (561 aa)
EPHA8EPH receptor A8. (1005 aa)
NTRK2Tyrosine-protein kinase receptor. (837 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
EPHA6Uncharacterized protein. (808 aa)
LYNTyrosine-protein kinase. (512 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (889 aa)
HCKTyrosine-protein kinase. (528 aa)
ABL1Tyrosine-protein kinase. (1151 aa)
EPHB4EPH receptor B4. (993 aa)
CD44CD44 molecule (Indian blood group). (715 aa)
EPHA1EPH receptor A1. (968 aa)
BTKTyrosine-protein kinase. (658 aa)
BMXTyrosine-protein kinase. (655 aa)
IL7RInterleukin 7 receptor. (459 aa)
CXCR5C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family. (374 aa)
EPHA7EPH receptor A7. (998 aa)
EGFRReceptor protein-tyrosine kinase. (1208 aa)
AXLAXL receptor tyrosine kinase. (887 aa)
OSMOncostatin M. (239 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1337 aa)
IL3RAUncharacterized protein. (510 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (379 aa)
NGFRNerve growth factor receptor. (427 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
IL11Interleukin 11. (191 aa)
ROS1Tyrosine-protein kinase receptor. (2319 aa)
CD86Ig-like domain-containing protein. (289 aa)
ANGPT1Angiopoietin 1. (488 aa)
GAS6Growth arrest specific 6. (671 aa)
EPHA2EPH receptor A2. (975 aa)
EPHA3EPH receptor A3. (984 aa)
FGRTyrosine-protein kinase. (527 aa)
CXCL10C-X-C motif chemokine. (102 aa)
CXCR3C-X-C chemokine receptor type 3; Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Binds to CCL21. Probably promotes cell chemotaxis response (By similarity). (367 aa)
SPP1Uncharacterized protein. (279 aa)
MATKTyrosine-protein kinase. (485 aa)
LIFRLIF receptor subunit alpha. (1066 aa)
TYRO3TYRO3 protein tyrosine kinase. (889 aa)
INSRTyrosine-protein kinase receptor. (1365 aa)
SRMSTyrosine-protein kinase. (494 aa)
LCKTyrosine-protein kinase. (509 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1139 aa)
TXKTyrosine-protein kinase. (527 aa)
IL7Interleukin 7. (181 aa)
TNFRSF1ATNF receptor superfamily member 1A. (449 aa)
JAK1Tyrosine-protein kinase. (1159 aa)
TNK2Tyrosine kinase non receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1086 aa)
ZAP70Tyrosine-protein kinase. (622 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
CSF2RBColony stimulating factor 2 receptor beta common subunit. (890 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (441 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (254 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
FGFR1Fibroblast growth factor receptor. (860 aa)
CD4CD4 molecule. (455 aa)
CD80CD80 molecule. (302 aa)
OSMROncostatin M receptor. (948 aa)
JAK3Tyrosine-protein kinase. (1138 aa)
FYNTyrosine-protein kinase. (537 aa)
TNK1Tyrosine kinase non receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (644 aa)
EPORErythropoietin receptor; Receptor for erythropoietin. (509 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (241 aa)
FGFR3Receptor protein-tyrosine kinase. (710 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1390 aa)
CCR8C-C motif chemokine receptor 8; Belongs to the G-protein coupled receptor 1 family. (366 aa)
FRKTyrosine-protein kinase. (515 aa)
CSF3RColony stimulating factor 3 receptor. (840 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (992 aa)
CD34Uncharacterized protein. (384 aa)
SRCTyrosine-protein kinase. (538 aa)
EPHB3EPH receptor B3. (999 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1108 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
LOC102179993G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (355 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
CSF2RAColony stimulating factor 2 receptor alpha subunit. (425 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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