28 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102169981	Histone domain-containing protein. (136 aa)
	LOC102185882	Histone H3; Belongs to the histone H3 family. (136 aa)
	RECQL4	RecQ like helicase 4. (1176 aa)
	LOC108633916	Histone H3; Belongs to the histone H3 family. (136 aa)
	LOC106503499	Histone H3; Belongs to the histone H3 family. (136 aa)
	LOC102180554	Histone H3; Belongs to the histone H3 family. (136 aa)
	RECQL5	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (991 aa)
	LOC108634231	Histone H3; Belongs to the histone H3 family. (136 aa)
	H3-4	Histone H3; Belongs to the histone H3 family. (136 aa)
	PXDN	Peroxidasin. (1525 aa)
	RAD17	RAD17 checkpoint clamp loader component. (709 aa)
	FANCC	Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (568 aa)
	LOC102189503	Histone H3; Belongs to the histone H3 family. (136 aa)
	HUS1	Checkpoint protein; Belongs to the HUS1 family. (280 aa)
	FANCD2	FA complementation group D2. (1423 aa)
	TOPBP1	DNA topoisomerase II binding protein 1. (1521 aa)
	RAD51	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
	AICDA	Activation induced cytidine deaminase. (199 aa)
	WRN	WRN RecQ like helicase. (1405 aa)
	RAD51C	RAD51 paralog C. (371 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	LOC108636012	Histone H3; Belongs to the histone H3 family. (136 aa)
	LOC102182848	Histone H3; Belongs to the histone H3 family. (136 aa)
	LOC108633554	Histone domain-containing protein. (136 aa)
	FANCA	FA complementation group A. (1416 aa)
	LOC102171353	Histone H3; Belongs to the histone H3 family. (136 aa)
	FANCI	FA complementation group I. (1086 aa)
	LOC102191748	Histone domain-containing protein. (136 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FANCA	FANCC	ENSCHIP00000001913	ENSCHIP00000024710	FA complementation group A.	Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1.	0.999
FANCA	FANCD2	ENSCHIP00000001913	ENSCHIP00000032582	FA complementation group A.	FA complementation group D2.	0.992
FANCA	FANCI	ENSCHIP00000001913	ENSCHIP00000001071	FA complementation group A.	FA complementation group I.	0.989
FANCA	RAD17	ENSCHIP00000001913	ENSCHIP00000023070	FA complementation group A.	RAD17 checkpoint clamp loader component.	0.533
FANCA	RAD51	ENSCHIP00000001913	ENSCHIP00000033023	FA complementation group A.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.700
FANCA	RAD51C	ENSCHIP00000001913	ENSCHIP00000013986	FA complementation group A.	RAD51 paralog C.	0.821
FANCA	RECQL4	ENSCHIP00000001913	ENSCHIP00000007755	FA complementation group A.	RecQ like helicase 4.	0.712
FANCA	RECQL5	ENSCHIP00000001913	ENSCHIP00000005703	FA complementation group A.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.565
FANCA	TOPBP1	ENSCHIP00000001913	ENSCHIP00000032843	FA complementation group A.	DNA topoisomerase II binding protein 1.	0.486
FANCA	WRN	ENSCHIP00000001913	ENSCHIP00000013642	FA complementation group A.	WRN RecQ like helicase.	0.737
FANCC	FANCA	ENSCHIP00000024710	ENSCHIP00000001913	Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1.	FA complementation group A.	0.999
FANCC	FANCD2	ENSCHIP00000024710	ENSCHIP00000032582	Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1.	FA complementation group D2.	0.998
FANCC	FANCI	ENSCHIP00000024710	ENSCHIP00000001071	Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1.	FA complementation group I.	0.997
FANCC	RAD51	ENSCHIP00000024710	ENSCHIP00000033023	Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.587
FANCC	RAD51C	ENSCHIP00000024710	ENSCHIP00000013986	Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1.	RAD51 paralog C.	0.804
FANCC	RECQL4	ENSCHIP00000024710	ENSCHIP00000007755	Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1.	RecQ like helicase 4.	0.487
FANCC	WRN	ENSCHIP00000024710	ENSCHIP00000013642	Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1.	WRN RecQ like helicase.	0.487
FANCD2	FANCA	ENSCHIP00000032582	ENSCHIP00000001913	FA complementation group D2.	FA complementation group A.	0.992
FANCD2	FANCC	ENSCHIP00000032582	ENSCHIP00000024710	FA complementation group D2.	Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1.	0.998
FANCD2	FANCI	ENSCHIP00000032582	ENSCHIP00000001071	FA complementation group D2.	FA complementation group I.	0.999