(20 nodes) (2014) AID downregulation is a novel function of the DNMT inhibitor 5-aza-deoxycytidine. network (Capra hircus)

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	BLNK	B cell linker. (384 aa)
	APOB	Apolipoprotein B. (4620 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	UCKL1	Uridine-cytidine kinase; Belongs to the uridine kinase family. (552 aa)
	DNMT3A	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (915 aa)
	ACTB	Uncharacterized protein. (375 aa)
	AICDA	Activation induced cytidine deaminase. (199 aa)
	UCK1	Uridine-cytidine kinase; Belongs to the uridine kinase family. (277 aa)
	RHOH	Ras homolog family member H. (191 aa)
	CDA	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (146 aa)
	BCL6	BCL6 transcription repressor. (706 aa)
	APOBEC2	Apolipoprotein B mRNA editing enzyme catalytic subunit 2. (224 aa)
	DCK	Deoxycytidine kinase. (260 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
	UCK2	Uridine-cytidine kinase; Belongs to the uridine kinase family. (261 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (495 aa)
	LMNA	Lamin A/C; Belongs to the intermediate filament family. (665 aa)
	RNF126	Ring finger protein 126. (313 aa)
	BCR	BCR activator of RhoGEF and GTPase. (1130 aa)
	PAX5	Paired box 5. (392 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	AICDA	ENSCHIP00000011080	ENSCHIP00000009604	Uncharacterized protein.	Activation induced cytidine deaminase.	0.434
ACTB	AKT1	ENSCHIP00000011080	ENSCHIP00000027335	Uncharacterized protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.755
ACTB	APOB	ENSCHIP00000011080	ENSCHIP00000016374	Uncharacterized protein.	Apolipoprotein B.	0.583
ACTB	BCL6	ENSCHIP00000011080	ENSCHIP00000032540	Uncharacterized protein.	BCL6 transcription repressor.	0.600
ACTB	DNMT3A	ENSCHIP00000011080	ENSCHIP00000012630	Uncharacterized protein.	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.729
ACTB	LMNA	ENSCHIP00000011080	ENSCHIP00000026441	Uncharacterized protein.	Lamin A/C; Belongs to the intermediate filament family.	0.847
ACTB	PAX5	ENSCHIP00000011080	ENSCHIP00000018891	Uncharacterized protein.	Paired box 5.	0.430
ACTB	TP53	ENSCHIP00000011080	ENSCHIP00000030141	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.907
AICDA	ACTB	ENSCHIP00000009604	ENSCHIP00000011080	Activation induced cytidine deaminase.	Uncharacterized protein.	0.434
AICDA	APOB	ENSCHIP00000009604	ENSCHIP00000016374	Activation induced cytidine deaminase.	Apolipoprotein B.	0.525
AICDA	APOBEC2	ENSCHIP00000009604	ENSCHIP00000032325	Activation induced cytidine deaminase.	Apolipoprotein B mRNA editing enzyme catalytic subunit 2.	0.421
AICDA	BCL6	ENSCHIP00000009604	ENSCHIP00000032540	Activation induced cytidine deaminase.	BCL6 transcription repressor.	0.951
AICDA	CDA	ENSCHIP00000009604	ENSCHIP00000033674	Activation induced cytidine deaminase.	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	0.680
AICDA	DCK	ENSCHIP00000009604	ENSCHIP00000030481	Activation induced cytidine deaminase.	Deoxycytidine kinase.	0.484
AICDA	PAX5	ENSCHIP00000009604	ENSCHIP00000018891	Activation induced cytidine deaminase.	Paired box 5.	0.880
AICDA	RNF126	ENSCHIP00000009604	ENSCHIP00000024305	Activation induced cytidine deaminase.	Ring finger protein 126.	0.562
AICDA	TP53	ENSCHIP00000009604	ENSCHIP00000030141	Activation induced cytidine deaminase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.444
AKT1	ACTB	ENSCHIP00000027335	ENSCHIP00000011080	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.755
AKT1	TP53	ENSCHIP00000027335	ENSCHIP00000030141	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.986
APOB	ACTB	ENSCHIP00000016374	ENSCHIP00000011080	Apolipoprotein B.	Uncharacterized protein.	0.583