(15 nodes) (2014) Dysregulation of Wnt inhibitory factor 1 (Wif1) expression resulted in aberrant Wnt-beta-catenin signaling and cell death of the cloaca endoderm, and anorectal malformations. network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
	GLB1	Beta-galactosidase. (646 aa)
	WIF1	WNT inhibitory factor 1. (379 aa)
	BMP7	Bone morphogenetic protein 7. (431 aa)
	WNT9A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (376 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (780 aa)
	GLB1L3	Beta-galactosidase. (664 aa)
	WNT7A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	GLI2	GLI family zinc finger 2. (1565 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	BMP7	ENSCHIP00000023678	ENSCHIP00000006043	Bone morphogenetic protein 4.	Bone morphogenetic protein 7.	0.778
BMP4	CTNNB1	ENSCHIP00000023678	ENSCHIP00000031016	Bone morphogenetic protein 4.	Catenin beta 1.	0.800
BMP4	GLI2	ENSCHIP00000023678	ENSCHIP00000017959	Bone morphogenetic protein 4.	GLI family zinc finger 2.	0.542
BMP4	SHH	ENSCHIP00000023678	ENSCHIP00000027767	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.909
BMP4	SMO	ENSCHIP00000023678	ENSCHIP00000027079	Bone morphogenetic protein 4.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.639
BMP4	WNT11	ENSCHIP00000023678	ENSCHIP00000024696	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.618
BMP4	WNT3A	ENSCHIP00000023678	ENSCHIP00000015590	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.874
BMP4	WNT4	ENSCHIP00000023678	ENSCHIP00000032708	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.636
BMP4	WNT5A	ENSCHIP00000023678	ENSCHIP00000015533	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.731
BMP4	WNT7A	ENSCHIP00000023678	ENSCHIP00000025727	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.541
BMP7	BMP4	ENSCHIP00000006043	ENSCHIP00000023678	Bone morphogenetic protein 7.	Bone morphogenetic protein 4.	0.778
BMP7	CTNNB1	ENSCHIP00000006043	ENSCHIP00000031016	Bone morphogenetic protein 7.	Catenin beta 1.	0.663
BMP7	GLI2	ENSCHIP00000006043	ENSCHIP00000017959	Bone morphogenetic protein 7.	GLI family zinc finger 2.	0.411
BMP7	SHH	ENSCHIP00000006043	ENSCHIP00000027767	Bone morphogenetic protein 7.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.697
BMP7	WNT11	ENSCHIP00000006043	ENSCHIP00000024696	Bone morphogenetic protein 7.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.534
BMP7	WNT3A	ENSCHIP00000006043	ENSCHIP00000015590	Bone morphogenetic protein 7.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.503
BMP7	WNT4	ENSCHIP00000006043	ENSCHIP00000032708	Bone morphogenetic protein 7.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.623
BMP7	WNT5A	ENSCHIP00000006043	ENSCHIP00000015533	Bone morphogenetic protein 7.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.519
CTNNB1	BMP4	ENSCHIP00000031016	ENSCHIP00000023678	Catenin beta 1.	Bone morphogenetic protein 4.	0.800
CTNNB1	BMP7	ENSCHIP00000031016	ENSCHIP00000006043	Catenin beta 1.	Bone morphogenetic protein 7.	0.663