(12 nodes) (2014) Dapper1 promotes autophagy by enhancing the Beclin1-Vps34-Atg14L complex formation. network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CALB1	Calbindin 1. (261 aa)
	ULK1	Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (1055 aa)
	ATG7	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (722 aa)
	AMBRA1	Autophagy and beclin 1 regulator 1. (1300 aa)
	LAMP1	Lysosomal associated membrane protein 1. (409 aa)
	BECN1	Uncharacterized protein. (448 aa)
	NES	Nestin; Belongs to the intermediate filament family. (1606 aa)
	GFAP	Glial fibrillary acidic protein; Belongs to the intermediate filament family. (428 aa)
	ATG12	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
	DVL2	Dishevelled segment polarity protein 2. (736 aa)
	UVRAG	UV radiation resistance associated. (699 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMBRA1	ATG12	ENSCHIP00000016753	ENSCHIP00000029307	Autophagy and beclin 1 regulator 1.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.761
AMBRA1	ATG5	ENSCHIP00000016753	ENSCHIP00000021333	Autophagy and beclin 1 regulator 1.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.801
AMBRA1	ATG7	ENSCHIP00000016753	ENSCHIP00000020049	Autophagy and beclin 1 regulator 1.	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	0.800
AMBRA1	BECN1	ENSCHIP00000016753	ENSCHIP00000024304	Autophagy and beclin 1 regulator 1.	Uncharacterized protein.	0.999
AMBRA1	ULK1	ENSCHIP00000016753	ENSCHIP00000020196	Autophagy and beclin 1 regulator 1.	Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.	0.979
AMBRA1	UVRAG	ENSCHIP00000016753	ENSCHIP00000031753	Autophagy and beclin 1 regulator 1.	UV radiation resistance associated.	0.979
ATG12	AMBRA1	ENSCHIP00000029307	ENSCHIP00000016753	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy and beclin 1 regulator 1.	0.761
ATG12	ATG5	ENSCHIP00000029307	ENSCHIP00000021333	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.999
ATG12	ATG7	ENSCHIP00000029307	ENSCHIP00000020049	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	0.999
ATG12	BECN1	ENSCHIP00000029307	ENSCHIP00000024304	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Uncharacterized protein.	0.977
ATG12	LAMP1	ENSCHIP00000029307	ENSCHIP00000000387	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Lysosomal associated membrane protein 1.	0.777
ATG12	ULK1	ENSCHIP00000029307	ENSCHIP00000020196	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.	0.930
ATG12	UVRAG	ENSCHIP00000029307	ENSCHIP00000031753	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	UV radiation resistance associated.	0.818
ATG5	AMBRA1	ENSCHIP00000021333	ENSCHIP00000016753	Autophagy protein 5; Involved in autophagic vesicle formation.	Autophagy and beclin 1 regulator 1.	0.801
ATG5	ATG12	ENSCHIP00000021333	ENSCHIP00000029307	Autophagy protein 5; Involved in autophagic vesicle formation.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.999
ATG5	ATG7	ENSCHIP00000021333	ENSCHIP00000020049	Autophagy protein 5; Involved in autophagic vesicle formation.	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	0.999
ATG5	BECN1	ENSCHIP00000021333	ENSCHIP00000024304	Autophagy protein 5; Involved in autophagic vesicle formation.	Uncharacterized protein.	0.986
ATG5	LAMP1	ENSCHIP00000021333	ENSCHIP00000000387	Autophagy protein 5; Involved in autophagic vesicle formation.	Lysosomal associated membrane protein 1.	0.910
ATG5	ULK1	ENSCHIP00000021333	ENSCHIP00000020196	Autophagy protein 5; Involved in autophagic vesicle formation.	Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.	0.965
ATG5	UVRAG	ENSCHIP00000021333	ENSCHIP00000031753	Autophagy protein 5; Involved in autophagic vesicle formation.	UV radiation resistance associated.	0.869