38 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ZEB1	Zinc finger E-box binding homeobox 1. (1127 aa)
	CUL4A	Cullin 4A; Belongs to the cullin family. (764 aa)
	VCL	Vinculin. (1134 aa)
	SRC	Tyrosine-protein kinase. (538 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (402 aa)
	FRK	Tyrosine-protein kinase. (515 aa)
	FYN	Tyrosine-protein kinase. (537 aa)
	DET1	Uncharacterized protein. (550 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
	ETV1	ETS variant 1. (477 aa)
	LCK	Tyrosine-protein kinase. (509 aa)
	PTK2	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1095 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (596 aa)
	DDB1	Damage specific DNA binding protein 1. (1140 aa)
	ETV5	Ets variant protein 5. (510 aa)
	ETS2	Protein C-ets-2; Transcription factor; Belongs to the ETS family. (470 aa)
	FGR	Tyrosine-protein kinase. (527 aa)
	ETS1	Uncharacterized protein. (485 aa)
	PXDN	Peroxidasin. (1525 aa)
	YAP1	Yes associated protein 1. (503 aa)
	COP1	COP1 E3 ubiquitin ligase. (739 aa)
	PTPRG	Protein tyrosine phosphatase receptor type G. (1392 aa)
	FOXO1	Forkhead box O1. (668 aa)
	SKP2	F-box domain-containing protein. (424 aa)
	MDM2	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
	EGFR	Receptor protein-tyrosine kinase. (1208 aa)
	ETV6	ETS variant 6. (452 aa)
	ZEB2	Zinc finger E-box binding homeobox 2. (1214 aa)
	TRIB1	Tribbles pseudokinase 1. (372 aa)
	CLDN1	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
	PGR	Progesterone receptor. (912 aa)
	HCK	Tyrosine-protein kinase. (528 aa)
	ATAD2	ATPase family AAA domain containing 2. (1385 aa)
	ETV4	ETS variant 4. (490 aa)
	CNN2	Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (309 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	RBX1	RING-type domain-containing protein. (108 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAD2	ESR1	ENSCHIP00000024961	ENSCHIP00000012243	ATPase family AAA domain containing 2.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.947
CLDN1	CTNNB1	ENSCHIP00000023835	ENSCHIP00000031016	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Catenin beta 1.	0.818
CLDN1	EGFR	ENSCHIP00000023835	ENSCHIP00000022759	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Receptor protein-tyrosine kinase.	0.637
CLDN1	INS	ENSCHIP00000023835	ENSCHIP00000007610	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.442
CLDN1	PXDN	ENSCHIP00000023835	ENSCHIP00000015493	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Peroxidasin.	0.680
CLDN1	ZEB1	ENSCHIP00000023835	ENSCHIP00000015942	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Zinc finger E-box binding homeobox 1.	0.663
CNN2	CTNNB1	ENSCHIP00000026998	ENSCHIP00000031016	Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.	Catenin beta 1.	0.410
CNN2	ESR1	ENSCHIP00000026998	ENSCHIP00000012243	Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.513
CNN2	INS	ENSCHIP00000026998	ENSCHIP00000007610	Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.406
CNN2	PXDN	ENSCHIP00000026998	ENSCHIP00000015493	Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.	Peroxidasin.	0.621
CNN2	SRC	ENSCHIP00000026998	ENSCHIP00000002619	Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.	Tyrosine-protein kinase.	0.514
CNN2	VCL	ENSCHIP00000026998	ENSCHIP00000000453	Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.	Vinculin.	0.722
COP1	CUL4A	ENSCHIP00000017712	ENSCHIP00000000333	COP1 E3 ubiquitin ligase.	Cullin 4A; Belongs to the cullin family.	0.844
COP1	DDB1	ENSCHIP00000017712	ENSCHIP00000013716	COP1 E3 ubiquitin ligase.	Damage specific DNA binding protein 1.	0.926
COP1	DET1	ENSCHIP00000017712	ENSCHIP00000006521	COP1 E3 ubiquitin ligase.	Uncharacterized protein.	0.986
COP1	ETV1	ENSCHIP00000017712	ENSCHIP00000009235	COP1 E3 ubiquitin ligase.	ETS variant 1.	0.705
COP1	ETV4	ENSCHIP00000017712	ENSCHIP00000026874	COP1 E3 ubiquitin ligase.	ETS variant 4.	0.587
COP1	ETV5	ENSCHIP00000017712	ENSCHIP00000013907	COP1 E3 ubiquitin ligase.	Ets variant protein 5.	0.777
COP1	RBX1	ENSCHIP00000017712	ENSCHIP00000031287	COP1 E3 ubiquitin ligase.	RING-type domain-containing protein.	0.801
COP1	TP53	ENSCHIP00000017712	ENSCHIP00000030141	COP1 E3 ubiquitin ligase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.900