12 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
	HIF1A	Uncharacterized protein. (823 aa)
	PKM	Pyruvate kinase; Belongs to the pyruvate kinase family. (531 aa)
	PHGDH	D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (533 aa)
	LDH-A	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (361 aa)
	SHMT2	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (502 aa)
	PGK2	Phosphoglycerate kinase. (417 aa)
	PKLR	Pyruvate kinase; Belongs to the pyruvate kinase family. (575 aa)
	PGK1	Phosphoglycerate kinase. (424 aa)
	PDK1	Protein-serine/threonine kinase. (438 aa)
	HK2	Hexokinase 2. (917 aa)
	SHMT1	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (484 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HIF1A	HK2	ENSCHIP00000014770	ENSCHIP00000009707	Uncharacterized protein.	Hexokinase 2.	0.721
HIF1A	LDH-A	ENSCHIP00000014770	ENSCHIP00000019303	Uncharacterized protein.	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily.	0.746
HIF1A	MYC	ENSCHIP00000014770	ENSCHIP00000011576	Uncharacterized protein.	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.791
HIF1A	PDK1	ENSCHIP00000014770	ENSCHIP00000009238	Uncharacterized protein.	Protein-serine/threonine kinase.	0.680
HIF1A	PGK1	ENSCHIP00000014770	ENSCHIP00000005700	Uncharacterized protein.	Phosphoglycerate kinase.	0.620
HIF1A	PGK2	ENSCHIP00000014770	ENSCHIP00000001811	Uncharacterized protein.	Phosphoglycerate kinase.	0.417
HIF1A	PKM	ENSCHIP00000014770	ENSCHIP00000015417	Uncharacterized protein.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.920
HK2	HIF1A	ENSCHIP00000009707	ENSCHIP00000014770	Hexokinase 2.	Uncharacterized protein.	0.721
HK2	LDH-A	ENSCHIP00000009707	ENSCHIP00000019303	Hexokinase 2.	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily.	0.857
HK2	PDK1	ENSCHIP00000009707	ENSCHIP00000009238	Hexokinase 2.	Protein-serine/threonine kinase.	0.779
HK2	PGK1	ENSCHIP00000009707	ENSCHIP00000005700	Hexokinase 2.	Phosphoglycerate kinase.	0.779
HK2	PGK2	ENSCHIP00000009707	ENSCHIP00000001811	Hexokinase 2.	Phosphoglycerate kinase.	0.566
HK2	PKLR	ENSCHIP00000009707	ENSCHIP00000002740	Hexokinase 2.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.615
HK2	PKM	ENSCHIP00000009707	ENSCHIP00000015417	Hexokinase 2.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.908
LDH-A	HIF1A	ENSCHIP00000019303	ENSCHIP00000014770	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily.	Uncharacterized protein.	0.746
LDH-A	HK2	ENSCHIP00000019303	ENSCHIP00000009707	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily.	Hexokinase 2.	0.857
LDH-A	PDK1	ENSCHIP00000019303	ENSCHIP00000009238	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily.	Protein-serine/threonine kinase.	0.748
LDH-A	PGK1	ENSCHIP00000019303	ENSCHIP00000005700	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily.	Phosphoglycerate kinase.	0.812
LDH-A	PGK2	ENSCHIP00000019303	ENSCHIP00000001811	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily.	Phosphoglycerate kinase.	0.566
LDH-A	PHGDH	ENSCHIP00000019303	ENSCHIP00000019405	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily.	D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.410