31 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ERBB3	Erb-b2 receptor tyrosine kinase 3. (1344 aa)
	COL15A1	Collagen type XV alpha 1 chain. (1375 aa)
	ERBB2	Receptor protein-tyrosine kinase. (1250 aa)
	ERBB4	Protein kinase domain-containing protein. (462 aa)
	COL1A2	Collagen type I alpha 2 chain. (1128 aa)
	PER2	Period circadian regulator 2. (1269 aa)
	PLSCR4	Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (333 aa)
	COL14A1	Collagen type XIV alpha 1 chain. (1775 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	COL4A1	Collagen type IV alpha 1 chain. (1608 aa)
	FBN1	Fibrillin 1. (2860 aa)
	RANBP3	RAN binding protein 3. (557 aa)
	SPARC	Osteonectin. (303 aa)
	NID1	Nidogen 1. (1252 aa)
	COL12A1	Collagen type XII alpha 1 chain. (3046 aa)
	GSR	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (519 aa)
	COL21A1	VWFA domain-containing protein. (454 aa)
	COL8A1	Collagen type VIII alpha 1 chain. (745 aa)
	F5	Coagulation factor V; Belongs to the multicopper oxidase family. (2112 aa)
	CRYAB	Crystallin alpha B; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	ACTB	Uncharacterized protein. (375 aa)
	KLF5	Uncharacterized protein. (454 aa)
	COL5A2	Collagen type V alpha 2 chain. (1252 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (550 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
	THBD	Thrombomodulin. (578 aa)
	PROS1	Protein S. (684 aa)
	GLS	Glutaminase. (673 aa)
	POSTN	Periostin. (836 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	COL1A2	ENSCHIP00000011080	ENSCHIP00000031191	Uncharacterized protein.	Collagen type I alpha 2 chain.	0.563
ACTB	ERBB2	ENSCHIP00000011080	ENSCHIP00000031717	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.755
ACTB	ERBB3	ENSCHIP00000011080	ENSCHIP00000012135	Uncharacterized protein.	Erb-b2 receptor tyrosine kinase 3.	0.593
ACTB	ERBB4	ENSCHIP00000011080	ENSCHIP00000031292	Uncharacterized protein.	Protein kinase domain-containing protein.	0.563
ACTB	GAPDH	ENSCHIP00000011080	ENSCHIP00000025974	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.979
ACTB	GSR	ENSCHIP00000011080	ENSCHIP00000016690	Uncharacterized protein.	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	0.593
ACTB	INS	ENSCHIP00000011080	ENSCHIP00000007610	Uncharacterized protein.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.884
ACTB	KLF5	ENSCHIP00000011080	ENSCHIP00000010022	Uncharacterized protein.	Uncharacterized protein.	0.460
ACTB	PER2	ENSCHIP00000011080	ENSCHIP00000027981	Uncharacterized protein.	Period circadian regulator 2.	0.511
ACTB	POSTN	ENSCHIP00000011080	ENSCHIP00000004170	Uncharacterized protein.	Periostin.	0.515
ACTB	SMAD3	ENSCHIP00000011080	ENSCHIP00000011729	Uncharacterized protein.	Mothers against decapentaplegic homolog.	0.847
ACTB	SPARC	ENSCHIP00000011080	ENSCHIP00000023372	Uncharacterized protein.	Osteonectin.	0.437
ACTB	TGFB1	ENSCHIP00000011080	ENSCHIP00000008885	Uncharacterized protein.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.831
ACTB	TGFBR2	ENSCHIP00000011080	ENSCHIP00000008226	Uncharacterized protein.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.615
ACTB	THBD	ENSCHIP00000011080	ENSCHIP00000007479	Uncharacterized protein.	Thrombomodulin.	0.425
COL12A1	COL15A1	ENSCHIP00000020533	ENSCHIP00000032260	Collagen type XII alpha 1 chain.	Collagen type XV alpha 1 chain.	0.471
COL12A1	COL1A2	ENSCHIP00000020533	ENSCHIP00000031191	Collagen type XII alpha 1 chain.	Collagen type I alpha 2 chain.	0.698
COL12A1	COL4A1	ENSCHIP00000020533	ENSCHIP00000025370	Collagen type XII alpha 1 chain.	Collagen type IV alpha 1 chain.	0.491
COL12A1	COL5A2	ENSCHIP00000020533	ENSCHIP00000009695	Collagen type XII alpha 1 chain.	Collagen type V alpha 2 chain.	0.661
COL12A1	COL8A1	ENSCHIP00000020533	ENSCHIP00000016115	Collagen type XII alpha 1 chain.	Collagen type VIII alpha 1 chain.	0.504