STRINGSTRING
HHIP HHIP CTNNB1 CTNNB1 PRKACB PRKACB SHH SHH SMO SMO PAX3 PAX3 GRK2 GRK2 GAPDH GAPDH SUFU SUFU MYOG MYOG BMP4 BMP4 GLI2 GLI2 FGF8 FGF8 PRKACA PRKACA MEF2C MEF2C GLI3 GLI3 NEUROD1 NEUROD1 ASCL1 ASCL1 NANOG NANOG TGFB1 TGFB1 FGF4 FGF4 MYOD1 MYOD1 KIF7 KIF7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HHIPHedgehog interacting protein. (701 aa)
CTNNB1Catenin beta 1. (781 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (780 aa)
PAX3Paired box 3. (484 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (694 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (485 aa)
MYOGMyogenin. (224 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
GLI2GLI family zinc finger 2. (1565 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (360 aa)
MEF2CMADS-box domain-containing protein. (441 aa)
GLI3GLI family zinc finger 3. (1614 aa)
NEUROD1Neurogenic differentiation factor. (356 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (219 aa)
NANOGHomeobox domain-containing protein. (300 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (319 aa)
KIF7Kinesin family member 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1351 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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