(13 nodes) (2014) Phosphorylation of ribosomal protein S6 kinase 1 at Thr421Ser424 and dephosphorylation at Thr389 regulates SP600125-induced polyploidization of megakaryocytic cell lines. network (Capra hircus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

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protein homology

Your Input:
	CD34	Uncharacterized protein. (384 aa)
	RPS6KB1	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (518 aa)
	EIF4E	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
	EEF2K	Eukaryotic elongation factor 2 kinase. (722 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
	EIF4B	RRM domain-containing protein. (615 aa)
	ACTB	Uncharacterized protein. (375 aa)
	PXDN	Peroxidasin. (1525 aa)
	CCNB1	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (427 aa)
	THPO	Thrombopoietin. (353 aa)
	EIF4EBP1	Uncharacterized protein. (118 aa)
	CD19	CD19 molecule. (561 aa)
	CCND3	Cyclin D3; Belongs to the cyclin family. (292 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	CCNB1	ENSCHIP00000011080	ENSCHIP00000015792	Uncharacterized protein.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.869
ACTB	CCND3	ENSCHIP00000011080	ENSCHIP00000033357	Uncharacterized protein.	Cyclin D3; Belongs to the cyclin family.	0.681
ACTB	CD19	ENSCHIP00000011080	ENSCHIP00000027580	Uncharacterized protein.	CD19 molecule.	0.754
ACTB	CD34	ENSCHIP00000011080	ENSCHIP00000002645	Uncharacterized protein.	Uncharacterized protein.	0.812
ACTB	EIF4B	ENSCHIP00000011080	ENSCHIP00000009582	Uncharacterized protein.	RRM domain-containing protein.	0.429
ACTB	EIF4E	ENSCHIP00000011080	ENSCHIP00000005408	Uncharacterized protein.	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	0.712
ACTB	EIF4EBP1	ENSCHIP00000011080	ENSCHIP00000020433	Uncharacterized protein.	Uncharacterized protein.	0.589
ACTB	INS	ENSCHIP00000011080	ENSCHIP00000007610	Uncharacterized protein.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.884
ACTB	PXDN	ENSCHIP00000011080	ENSCHIP00000015493	Uncharacterized protein.	Peroxidasin.	0.962
ACTB	RPS6KB1	ENSCHIP00000011080	ENSCHIP00000002789	Uncharacterized protein.	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	0.711
CCNB1	ACTB	ENSCHIP00000015792	ENSCHIP00000011080	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Uncharacterized protein.	0.869
CCNB1	INS	ENSCHIP00000015792	ENSCHIP00000007610	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.444
CCNB1	PXDN	ENSCHIP00000015792	ENSCHIP00000015493	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Peroxidasin.	0.744
CCND3	ACTB	ENSCHIP00000033357	ENSCHIP00000011080	Cyclin D3; Belongs to the cyclin family.	Uncharacterized protein.	0.681
CCND3	PXDN	ENSCHIP00000033357	ENSCHIP00000015493	Cyclin D3; Belongs to the cyclin family.	Peroxidasin.	0.510
CD19	ACTB	ENSCHIP00000027580	ENSCHIP00000011080	CD19 molecule.	Uncharacterized protein.	0.754
CD19	CD34	ENSCHIP00000027580	ENSCHIP00000002645	CD19 molecule.	Uncharacterized protein.	0.930
CD19	INS	ENSCHIP00000027580	ENSCHIP00000007610	CD19 molecule.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.617
CD19	PXDN	ENSCHIP00000027580	ENSCHIP00000015493	CD19 molecule.	Peroxidasin.	0.750
CD19	THPO	ENSCHIP00000027580	ENSCHIP00000018239	CD19 molecule.	Thrombopoietin.	0.521