(17 nodes) (2015) Proteotoxic stress induces phosphorylation of p62SQSTM1 by ULK1 to regulate selective autophagic clearance of protein aggregates. network (Capra hircus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Others

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protein homology

Your Input:
	LAMP2	Lysosomal associated membrane protein 2. (494 aa)
	KEAP1	Kelch like ECH associated protein 1. (624 aa)
	SYN3	Synapsin III. (339 aa)
	FUNDC1	Uncharacterized protein. (155 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
	BECN1	Uncharacterized protein. (448 aa)
	SYN2	Synapsin II. (587 aa)
	WIPI2	WD repeat domain, phosphoinositide interacting 2. (436 aa)
	NES	Nestin; Belongs to the intermediate filament family. (1606 aa)
	HTT	Uncharacterized protein. (2830 aa)
	ULK2	Unc-51 like autophagy activating kinase 2. (1035 aa)
	NBR1	NBR1 autophagy cargo receptor. (988 aa)
	ATG101	Autophagy related 101. (218 aa)
	AMBRA1	Autophagy and beclin 1 regulator 1. (1300 aa)
	ATG13	Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (517 aa)
	ATG7	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (722 aa)
	ACTB	Uncharacterized protein. (375 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ATG13	ENSCHIP00000011080	ENSCHIP00000013146	Uncharacterized protein.	Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily.	0.502
ACTB	ATG7	ENSCHIP00000011080	ENSCHIP00000020049	Uncharacterized protein.	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	0.807
ACTB	BECN1	ENSCHIP00000011080	ENSCHIP00000024304	Uncharacterized protein.	Uncharacterized protein.	0.886
ACTB	HTT	ENSCHIP00000011080	ENSCHIP00000032883	Uncharacterized protein.	Uncharacterized protein.	0.686
ACTB	KEAP1	ENSCHIP00000011080	ENSCHIP00000009131	Uncharacterized protein.	Kelch like ECH associated protein 1.	0.780
ACTB	LAMP2	ENSCHIP00000011080	ENSCHIP00000010102	Uncharacterized protein.	Lysosomal associated membrane protein 2.	0.703
ACTB	MTOR	ENSCHIP00000011080	ENSCHIP00000021872	Uncharacterized protein.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.734
ACTB	NES	ENSCHIP00000011080	ENSCHIP00000032395	Uncharacterized protein.	Nestin; Belongs to the intermediate filament family.	0.800
ACTB	SYN2	ENSCHIP00000011080	ENSCHIP00000029976	Uncharacterized protein.	Synapsin II.	0.582
ACTB	SYN3	ENSCHIP00000011080	ENSCHIP00000020610	Uncharacterized protein.	Synapsin III.	0.563
AMBRA1	ATG101	ENSCHIP00000016753	ENSCHIP00000017295	Autophagy and beclin 1 regulator 1.	Autophagy related 101.	0.864
AMBRA1	ATG13	ENSCHIP00000016753	ENSCHIP00000013146	Autophagy and beclin 1 regulator 1.	Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily.	0.914
AMBRA1	ATG7	ENSCHIP00000016753	ENSCHIP00000020049	Autophagy and beclin 1 regulator 1.	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	0.800
AMBRA1	BECN1	ENSCHIP00000016753	ENSCHIP00000024304	Autophagy and beclin 1 regulator 1.	Uncharacterized protein.	0.999
AMBRA1	FUNDC1	ENSCHIP00000016753	ENSCHIP00000021710	Autophagy and beclin 1 regulator 1.	Uncharacterized protein.	0.768
AMBRA1	MTOR	ENSCHIP00000016753	ENSCHIP00000021872	Autophagy and beclin 1 regulator 1.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.430
AMBRA1	NBR1	ENSCHIP00000016753	ENSCHIP00000027565	Autophagy and beclin 1 regulator 1.	NBR1 autophagy cargo receptor.	0.591
AMBRA1	ULK2	ENSCHIP00000016753	ENSCHIP00000007944	Autophagy and beclin 1 regulator 1.	Unc-51 like autophagy activating kinase 2.	0.984
AMBRA1	WIPI2	ENSCHIP00000016753	ENSCHIP00000030756	Autophagy and beclin 1 regulator 1.	WD repeat domain, phosphoinositide interacting 2.	0.475
ATG101	AMBRA1	ENSCHIP00000017295	ENSCHIP00000016753	Autophagy related 101.	Autophagy and beclin 1 regulator 1.	0.864