(11 nodes) (2015) Effect of MPG gene rs2858056 polymorphism, copy number variation, and level of serum MPG protein on the risk for rheumatoid arthritis. network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PXDN	Peroxidasin. (1525 aa)
	CTLA4	Cytotoxic T-lymphocyte associated protein 4. (221 aa)
	SMUG1	Single-strand-selective monofunctional uracil-DNA glycosylase 1. (324 aa)
	MUTYH	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (605 aa)
	MPG	N-methylpurine DNA glycosylase. (371 aa)
	PTPN22	Protein tyrosine phosphatase non-receptor type 22. (795 aa)
	CRP	Pentaxin. (227 aa)
	TDG	Thymine DNA glycosylase. (403 aa)
	EGFR	Receptor protein-tyrosine kinase. (1208 aa)
	TNFAIP3	TNF alpha induced protein 3. (785 aa)
	OGG1	8-oxoguanine DNA glycosylase. (345 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRP	PXDN	ENSCHIP00000014055	ENSCHIP00000015493	Pentaxin.	Peroxidasin.	0.658
CTLA4	EGFR	ENSCHIP00000003886	ENSCHIP00000022759	Cytotoxic T-lymphocyte associated protein 4.	Receptor protein-tyrosine kinase.	0.629
CTLA4	PTPN22	ENSCHIP00000003886	ENSCHIP00000012679	Cytotoxic T-lymphocyte associated protein 4.	Protein tyrosine phosphatase non-receptor type 22.	0.723
CTLA4	PXDN	ENSCHIP00000003886	ENSCHIP00000015493	Cytotoxic T-lymphocyte associated protein 4.	Peroxidasin.	0.580
EGFR	CTLA4	ENSCHIP00000022759	ENSCHIP00000003886	Receptor protein-tyrosine kinase.	Cytotoxic T-lymphocyte associated protein 4.	0.629
EGFR	PTPN22	ENSCHIP00000022759	ENSCHIP00000012679	Receptor protein-tyrosine kinase.	Protein tyrosine phosphatase non-receptor type 22.	0.626
EGFR	PXDN	ENSCHIP00000022759	ENSCHIP00000015493	Receptor protein-tyrosine kinase.	Peroxidasin.	0.846
MPG	MUTYH	ENSCHIP00000008030	ENSCHIP00000007858	N-methylpurine DNA glycosylase.	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs.	0.572
MPG	OGG1	ENSCHIP00000008030	ENSCHIP00000026279	N-methylpurine DNA glycosylase.	8-oxoguanine DNA glycosylase.	0.731
MPG	SMUG1	ENSCHIP00000008030	ENSCHIP00000005961	N-methylpurine DNA glycosylase.	Single-strand-selective monofunctional uracil-DNA glycosylase 1.	0.804
MPG	TDG	ENSCHIP00000008030	ENSCHIP00000014377	N-methylpurine DNA glycosylase.	Thymine DNA glycosylase.	0.604
MUTYH	MPG	ENSCHIP00000007858	ENSCHIP00000008030	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs.	N-methylpurine DNA glycosylase.	0.572
MUTYH	OGG1	ENSCHIP00000007858	ENSCHIP00000026279	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs.	8-oxoguanine DNA glycosylase.	0.968
MUTYH	SMUG1	ENSCHIP00000007858	ENSCHIP00000005961	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs.	Single-strand-selective monofunctional uracil-DNA glycosylase 1.	0.545
MUTYH	TDG	ENSCHIP00000007858	ENSCHIP00000014377	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs.	Thymine DNA glycosylase.	0.656
OGG1	MPG	ENSCHIP00000026279	ENSCHIP00000008030	8-oxoguanine DNA glycosylase.	N-methylpurine DNA glycosylase.	0.731
OGG1	MUTYH	ENSCHIP00000026279	ENSCHIP00000007858	8-oxoguanine DNA glycosylase.	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs.	0.968
OGG1	SMUG1	ENSCHIP00000026279	ENSCHIP00000005961	8-oxoguanine DNA glycosylase.	Single-strand-selective monofunctional uracil-DNA glycosylase 1.	0.745
OGG1	TDG	ENSCHIP00000026279	ENSCHIP00000014377	8-oxoguanine DNA glycosylase.	Thymine DNA glycosylase.	0.804
PTPN22	CTLA4	ENSCHIP00000012679	ENSCHIP00000003886	Protein tyrosine phosphatase non-receptor type 22.	Cytotoxic T-lymphocyte associated protein 4.	0.723