(23 nodes) (2015) Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via melanocortin receptors 1, 2 and 5. network (Capra hircus)

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Predicted Interactions

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Your Input:
	MYL2	Myosin light chain 2. (178 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (396 aa)
	JAK2	Tyrosine-protein kinase. (1132 aa)
	MC4R	Melanocortin 4 receptor. (332 aa)
	MC2R	Melanocortin 2 receptor. (297 aa)
	CD34	Uncharacterized protein. (384 aa)
	EPOR	Erythropoietin receptor; Receptor for erythropoietin. (509 aa)
	LOC102176799	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	GAPDHS	Glyceraldehyde-3-phosphate dehydrogenase. (385 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
	LOC102181016	Gp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (318 aa)
	RHOA	Ras-like protein family member A. (193 aa)
	LIF	LIF interleukin 6 family cytokine. (202 aa)
	PXDN	Peroxidasin. (1525 aa)
	THPO	Thrombopoietin. (353 aa)
	LOC102190507	Uncharacterized protein. (139 aa)
	ALB	Serum albumin. (608 aa)
	MC5R	Melanocortin 5 receptor. (325 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	KITLG	Processed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity); Belongs to the SCF family. (274 aa)
	EPO	Erythropoietin. (208 aa)
	MCL1	MCL1 apoptosis regulator, BCL2 family member. (350 aa)
	TFRC	Transferrin receptor. (790 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALB	CD34	ENSCHIP00000020234	ENSCHIP00000002645	Serum albumin.	Uncharacterized protein.	0.856
ALB	EPO	ENSCHIP00000020234	ENSCHIP00000031030	Serum albumin.	Erythropoietin.	0.712
ALB	EPOR	ENSCHIP00000020234	ENSCHIP00000004454	Serum albumin.	Erythropoietin receptor; Receptor for erythropoietin.	0.427
ALB	GAPDH	ENSCHIP00000020234	ENSCHIP00000025974	Serum albumin.	Glyceraldehyde-3-phosphate dehydrogenase.	0.948
ALB	GAPDHS	ENSCHIP00000020234	ENSCHIP00000005676	Serum albumin.	Glyceraldehyde-3-phosphate dehydrogenase.	0.888
ALB	IL6	ENSCHIP00000020234	ENSCHIP00000009414	Serum albumin.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.897
ALB	JAK2	ENSCHIP00000020234	ENSCHIP00000001875	Serum albumin.	Tyrosine-protein kinase.	0.666
ALB	KITLG	ENSCHIP00000020234	ENSCHIP00000030559	Serum albumin.	Processed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity); Belongs to the SCF family.	0.665
ALB	LIF	ENSCHIP00000020234	ENSCHIP00000012397	Serum albumin.	LIF interleukin 6 family cytokine.	0.677
ALB	LOC102176799	ENSCHIP00000020234	ENSCHIP00000004827	Serum albumin.	Glyceraldehyde-3-phosphate dehydrogenase.	0.914
ALB	LOC102181016	ENSCHIP00000020234	ENSCHIP00000010405	Serum albumin.	Gp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.	0.919
ALB	LOC102190507	ENSCHIP00000020234	ENSCHIP00000018311	Serum albumin.	Uncharacterized protein.	0.704
ALB	MAPK1	ENSCHIP00000020234	ENSCHIP00000000204	Serum albumin.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.496
ALB	MCL1	ENSCHIP00000020234	ENSCHIP00000033441	Serum albumin.	MCL1 apoptosis regulator, BCL2 family member.	0.580
ALB	PXDN	ENSCHIP00000020234	ENSCHIP00000015493	Serum albumin.	Peroxidasin.	0.988
ALB	RHOA	ENSCHIP00000020234	ENSCHIP00000011951	Serum albumin.	Ras-like protein family member A.	0.773
ALB	TFRC	ENSCHIP00000020234	ENSCHIP00000033446	Serum albumin.	Transferrin receptor.	0.752
ALB	THPO	ENSCHIP00000020234	ENSCHIP00000018239	Serum albumin.	Thrombopoietin.	0.559
CD34	ALB	ENSCHIP00000002645	ENSCHIP00000020234	Uncharacterized protein.	Serum albumin.	0.856
CD34	EPO	ENSCHIP00000002645	ENSCHIP00000031030	Uncharacterized protein.	Erythropoietin.	0.772