STRINGSTRING
GPR55 GPR55 CD24 CD24 SMAD3 SMAD3 CASP3 CASP3 ACTB ACTB CCND1 CCND1 PLAT PLAT TNF TNF ENSCHIP00000004646 ENSCHIP00000004646 B2M B2M IL2 IL2 CD69 CD69 ERBB2 ERBB2 CTNNB1 CTNNB1 HCRT HCRT TP53 TP53 CD68 CD68 ULBP3 ULBP3 EPCAM EPCAM GAPDH GAPDH STAT3 STAT3 SMAD2 SMAD2 LEP LEP ALB ALB LOC102168547 LOC102168547 IFNG IFNG BCL2 BCL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GPR55G protein-coupled receptor 55; Belongs to the G-protein coupled receptor 1 family. (329 aa)
CD24Uncharacterized protein. (78 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (275 aa)
ACTBUncharacterized protein. (375 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (565 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
ENSCHIP00000004646Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (118 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (124 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (155 aa)
CD69CD69 molecule. (199 aa)
ERBB2Receptor protein-tyrosine kinase. (1250 aa)
CTNNB1Catenin beta 1. (781 aa)
HCRTOrexin; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Belongs to the orexin family. (131 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
CD68CD68 molecule. (335 aa)
ULBP3MHC_I-like_Ag-recog domain-containing protein. (245 aa)
EPCAMEpithelial cell adhesion molecule. (314 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (192 aa)
ALBSerum albumin. (608 aa)
LOC102168547Beta-2-microglobulin. (124 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
BCL2BH4_2 domain-containing protein. (229 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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