node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CAV1 | TSG101 | ENSCHIP00000020742 | ENSCHIP00000011190 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. | Uncharacterized protein. | 0.458 |
ERCC1 | FEN1 | ENSCHIP00000031141 | ENSCHIP00000005017 | ERCC excision repair 1, endonuclease non-catalytic subunit. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.834 |
ERCC1 | RAD50 | ENSCHIP00000031141 | ENSCHIP00000003154 | ERCC excision repair 1, endonuclease non-catalytic subunit. | Zinc-hook domain-containing protein. | 0.449 |
ERCC1 | RTL1 | ENSCHIP00000031141 | ENSCHIP00000006993 | ERCC excision repair 1, endonuclease non-catalytic subunit. | Retrotransposon Gag like 1. | 0.541 |
ERCC1 | TIMELESS | ENSCHIP00000031141 | ENSCHIP00000007177 | ERCC excision repair 1, endonuclease non-catalytic subunit. | Timeless circadian regulator. | 0.430 |
ERCC1 | WRN | ENSCHIP00000031141 | ENSCHIP00000013642 | ERCC excision repair 1, endonuclease non-catalytic subunit. | WRN RecQ like helicase. | 0.827 |
FEN1 | ERCC1 | ENSCHIP00000005017 | ENSCHIP00000031141 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | ERCC excision repair 1, endonuclease non-catalytic subunit. | 0.834 |
FEN1 | PCNA | ENSCHIP00000005017 | ENSCHIP00000015091 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.997 |
FEN1 | PRIM1 | ENSCHIP00000005017 | ENSCHIP00000033299 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA primase; Belongs to the eukaryotic-type primase small subunit family. | 0.965 |
FEN1 | RAD50 | ENSCHIP00000005017 | ENSCHIP00000003154 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Zinc-hook domain-containing protein. | 0.909 |
FEN1 | RTL1 | ENSCHIP00000005017 | ENSCHIP00000006993 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Retrotransposon Gag like 1. | 0.418 |
FEN1 | TIMELESS | ENSCHIP00000005017 | ENSCHIP00000007177 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Timeless circadian regulator. | 0.735 |
FEN1 | WRN | ENSCHIP00000005017 | ENSCHIP00000013642 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | WRN RecQ like helicase. | 0.998 |
PCNA | FEN1 | ENSCHIP00000015091 | ENSCHIP00000005017 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.997 |
PCNA | PRIM1 | ENSCHIP00000015091 | ENSCHIP00000033299 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | DNA primase; Belongs to the eukaryotic-type primase small subunit family. | 0.961 |
PCNA | RAD50 | ENSCHIP00000015091 | ENSCHIP00000003154 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | Zinc-hook domain-containing protein. | 0.464 |
PCNA | WRN | ENSCHIP00000015091 | ENSCHIP00000013642 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | WRN RecQ like helicase. | 0.974 |
PRIM1 | FEN1 | ENSCHIP00000033299 | ENSCHIP00000005017 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.965 |
PRIM1 | PCNA | ENSCHIP00000033299 | ENSCHIP00000015091 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.961 |
PRIM1 | TIMELESS | ENSCHIP00000033299 | ENSCHIP00000007177 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. | Timeless circadian regulator. | 0.456 |