(13 nodes) (2015) Interrupted E2F1-miR-34c-SCF negative feedback loop by hyper-methylation promotes colorectal cancer cell proliferation. network (Capra hircus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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Predicted Interactions

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Your Input:
	MYB	MYB proto-oncogene, transcription factor. (640 aa)
	SNAI1	Snail family transcriptional repressor 1. (264 aa)
	E2F1	E2F transcription factor 1. (441 aa)
	SIRT1	Deacetylase sirtuin-type domain-containing protein. (732 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	KITLG	Processed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity); Belongs to the SCF family. (274 aa)
	E2F3	E2F_TDP domain-containing protein. (460 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
	MMUT	Methylmalonyl-CoA mutase. (771 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	KIT	Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (974 aa)
	ACTB	Uncharacterized protein. (375 aa)
	BCL2	BH4_2 domain-containing protein. (229 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	BCL2	ENSCHIP00000011080	ENSCHIP00000015831	Uncharacterized protein.	BH4_2 domain-containing protein.	0.940
ACTB	CTNNB1	ENSCHIP00000011080	ENSCHIP00000031016	Uncharacterized protein.	Catenin beta 1.	0.906
ACTB	E2F1	ENSCHIP00000011080	ENSCHIP00000014803	Uncharacterized protein.	E2F transcription factor 1.	0.716
ACTB	E2F3	ENSCHIP00000011080	ENSCHIP00000007013	Uncharacterized protein.	E2F_TDP domain-containing protein.	0.400
ACTB	GAPDH	ENSCHIP00000011080	ENSCHIP00000025974	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.979
ACTB	KIT	ENSCHIP00000011080	ENSCHIP00000025751	Uncharacterized protein.	Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...]	0.719
ACTB	KITLG	ENSCHIP00000011080	ENSCHIP00000030559	Uncharacterized protein.	Processed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity); Belongs to the SCF family.	0.654
ACTB	MMUT	ENSCHIP00000011080	ENSCHIP00000027222	Uncharacterized protein.	Methylmalonyl-CoA mutase.	0.806
ACTB	SIRT1	ENSCHIP00000011080	ENSCHIP00000007571	Uncharacterized protein.	Deacetylase sirtuin-type domain-containing protein.	0.852
ACTB	SNAI1	ENSCHIP00000011080	ENSCHIP00000012596	Uncharacterized protein.	Snail family transcriptional repressor 1.	0.706
ACTB	TP53	ENSCHIP00000011080	ENSCHIP00000030141	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.907
BCL2	ACTB	ENSCHIP00000015831	ENSCHIP00000011080	BH4_2 domain-containing protein.	Uncharacterized protein.	0.940
BCL2	CTNNB1	ENSCHIP00000015831	ENSCHIP00000031016	BH4_2 domain-containing protein.	Catenin beta 1.	0.820
BCL2	E2F1	ENSCHIP00000015831	ENSCHIP00000014803	BH4_2 domain-containing protein.	E2F transcription factor 1.	0.711
BCL2	E2F3	ENSCHIP00000015831	ENSCHIP00000007013	BH4_2 domain-containing protein.	E2F_TDP domain-containing protein.	0.491
BCL2	GAPDH	ENSCHIP00000015831	ENSCHIP00000025974	BH4_2 domain-containing protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.941
BCL2	KIT	ENSCHIP00000015831	ENSCHIP00000025751	BH4_2 domain-containing protein.	Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...]	0.564
BCL2	KITLG	ENSCHIP00000015831	ENSCHIP00000030559	BH4_2 domain-containing protein.	Processed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity); Belongs to the SCF family.	0.452
BCL2	MMUT	ENSCHIP00000015831	ENSCHIP00000027222	BH4_2 domain-containing protein.	Methylmalonyl-CoA mutase.	0.740
BCL2	SIRT1	ENSCHIP00000015831	ENSCHIP00000007571	BH4_2 domain-containing protein.	Deacetylase sirtuin-type domain-containing protein.	0.785