(11 nodes) (2016) Induction of autophagy promotes the growth of early preneoplastic rat liver nodules. network (Capra hircus)

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Your Input:
	ATG7	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (722 aa)
	ULK1	Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (1055 aa)
	UVRAG	UV radiation resistance associated. (699 aa)
	ATG12	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	BECN1	Uncharacterized protein. (448 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	BCL2	BH4_2 domain-containing protein. (229 aa)
	AMBRA1	Autophagy and beclin 1 regulator 1. (1300 aa)
	FOXO3	Forkhead box O3. (672 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (774 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMBRA1	ATG12	ENSCHIP00000016753	ENSCHIP00000029307	Autophagy and beclin 1 regulator 1.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.761
AMBRA1	ATG5	ENSCHIP00000016753	ENSCHIP00000021333	Autophagy and beclin 1 regulator 1.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.801
AMBRA1	ATG7	ENSCHIP00000016753	ENSCHIP00000020049	Autophagy and beclin 1 regulator 1.	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	0.800
AMBRA1	BCL2	ENSCHIP00000016753	ENSCHIP00000015831	Autophagy and beclin 1 regulator 1.	BH4_2 domain-containing protein.	0.731
AMBRA1	BECN1	ENSCHIP00000016753	ENSCHIP00000024304	Autophagy and beclin 1 regulator 1.	Uncharacterized protein.	0.999
AMBRA1	ULK1	ENSCHIP00000016753	ENSCHIP00000020196	Autophagy and beclin 1 regulator 1.	Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.	0.979
AMBRA1	UVRAG	ENSCHIP00000016753	ENSCHIP00000031753	Autophagy and beclin 1 regulator 1.	UV radiation resistance associated.	0.979
ATG12	AMBRA1	ENSCHIP00000029307	ENSCHIP00000016753	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy and beclin 1 regulator 1.	0.761
ATG12	ATG5	ENSCHIP00000029307	ENSCHIP00000021333	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.999
ATG12	ATG7	ENSCHIP00000029307	ENSCHIP00000020049	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	0.999
ATG12	BCL2	ENSCHIP00000029307	ENSCHIP00000015831	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	BH4_2 domain-containing protein.	0.780
ATG12	BECN1	ENSCHIP00000029307	ENSCHIP00000024304	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Uncharacterized protein.	0.977
ATG12	FOXO3	ENSCHIP00000029307	ENSCHIP00000019148	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Forkhead box O3.	0.526
ATG12	GAPDH	ENSCHIP00000029307	ENSCHIP00000025974	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Glyceraldehyde-3-phosphate dehydrogenase.	0.695
ATG12	ULK1	ENSCHIP00000029307	ENSCHIP00000020196	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.	0.930
ATG12	UVRAG	ENSCHIP00000029307	ENSCHIP00000031753	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	UV radiation resistance associated.	0.818
ATG5	AMBRA1	ENSCHIP00000021333	ENSCHIP00000016753	Autophagy protein 5; Involved in autophagic vesicle formation.	Autophagy and beclin 1 regulator 1.	0.801
ATG5	ATG12	ENSCHIP00000021333	ENSCHIP00000029307	Autophagy protein 5; Involved in autophagic vesicle formation.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.999
ATG5	ATG7	ENSCHIP00000021333	ENSCHIP00000020049	Autophagy protein 5; Involved in autophagic vesicle formation.	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	0.999
ATG5	BCL2	ENSCHIP00000021333	ENSCHIP00000015831	Autophagy protein 5; Involved in autophagic vesicle formation.	BH4_2 domain-containing protein.	0.863