(25 nodes) (2016) A Shh-Foxf-Fgf18-Shh Molecular Circuit Regulating Palate Development. network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PTCH1	Patched 1. (1453 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	FOXD2	Forkhead box D2. (486 aa)
	FOXD1	Forkhead box D1. (479 aa)
	FGFR3	Receptor protein-tyrosine kinase. (710 aa)
	DLX5	Distal-less homeobox 5. (289 aa)
	FGFR1	Fibroblast growth factor receptor. (860 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	ACTB	Uncharacterized protein. (375 aa)
	MSX1	Msh homeobox 1. (303 aa)
	GLI3	GLI family zinc finger 3. (1614 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	SHOX2	Short stature homeobox 2. (319 aa)
	GLI2	GLI family zinc finger 2. (1565 aa)
	FGFR2	Fibroblast growth factor receptor. (841 aa)
	BARX1	BARX homeobox 1. (254 aa)
	FOXF1	Forkhead box F1. (391 aa)
	OSR2	Odd-skipped related transciption factor 2. (276 aa)
	FOXF2	Forkhead box F2. (437 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (780 aa)
	FGFR4	Fibroblast growth factor receptor. (870 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
	FOXC2	Forkhead box C2. (486 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	BMP4	ENSCHIP00000011080	ENSCHIP00000023678	Uncharacterized protein.	Bone morphogenetic protein 4.	0.697
ACTB	BMPR1A	ENSCHIP00000011080	ENSCHIP00000000640	Uncharacterized protein.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.402
ACTB	FGF10	ENSCHIP00000011080	ENSCHIP00000010028	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.589
ACTB	FGF18	ENSCHIP00000011080	ENSCHIP00000008198	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.534
ACTB	FGF7	ENSCHIP00000011080	ENSCHIP00000014609	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.593
ACTB	FGFR1	ENSCHIP00000011080	ENSCHIP00000007607	Uncharacterized protein.	Fibroblast growth factor receptor.	0.691
ACTB	FGFR2	ENSCHIP00000011080	ENSCHIP00000018620	Uncharacterized protein.	Fibroblast growth factor receptor.	0.624
ACTB	FGFR3	ENSCHIP00000011080	ENSCHIP00000003263	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.530
ACTB	FGFR4	ENSCHIP00000011080	ENSCHIP00000027592	Uncharacterized protein.	Fibroblast growth factor receptor.	0.543
ACTB	GLI2	ENSCHIP00000011080	ENSCHIP00000017959	Uncharacterized protein.	GLI family zinc finger 2.	0.598
ACTB	GLI3	ENSCHIP00000011080	ENSCHIP00000014153	Uncharacterized protein.	GLI family zinc finger 3.	0.540
ACTB	PTCH1	ENSCHIP00000011080	ENSCHIP00000011891	Uncharacterized protein.	Patched 1.	0.541
ACTB	SHH	ENSCHIP00000011080	ENSCHIP00000027767	Uncharacterized protein.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.702
ACTB	SMO	ENSCHIP00000011080	ENSCHIP00000027079	Uncharacterized protein.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.618
BARX1	BMP4	ENSCHIP00000018825	ENSCHIP00000023678	BARX homeobox 1.	Bone morphogenetic protein 4.	0.568
BARX1	FGF10	ENSCHIP00000018825	ENSCHIP00000010028	BARX homeobox 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.423
BARX1	FOXF1	ENSCHIP00000018825	ENSCHIP00000020087	BARX homeobox 1.	Forkhead box F1.	0.424
BARX1	FOXF2	ENSCHIP00000018825	ENSCHIP00000022344	BARX homeobox 1.	Forkhead box F2.	0.440
BARX1	GLI2	ENSCHIP00000018825	ENSCHIP00000017959	BARX homeobox 1.	GLI family zinc finger 2.	0.420
BARX1	MSX1	ENSCHIP00000018825	ENSCHIP00000012268	BARX homeobox 1.	Msh homeobox 1.	0.489