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RAB7A RAB7A FH FH PKLR PKLR OGDH OGDH ACO2 ACO2 ALDH7A1 ALDH7A1 ENSCHIP00000004162 ENSCHIP00000004162 SUMO1 SUMO1 RPS6 RPS6 SUMO4 SUMO4 ATP5F1B ATP5F1B NOP10 NOP10 FAH FAH ACTB ACTB ALDOA ALDOA LAMC1 LAMC1 PSMA7 PSMA7 ATP5F1A ATP5F1A AARS1 AARS1 CFL2 CFL2 SUMO3 SUMO3 ENO1 ENO1 PKM PKM ALDH4A1 ALDH4A1 PELO PELO CSTF2 CSTF2 HYOU1 HYOU1 SDHA SDHA UCHL3 UCHL3 AARS2 AARS2 DERL1 DERL1 NARS1 NARS1 MTOR MTOR HDAC1 HDAC1 ACAT1 ACAT1 CACYBP CACYBP GAPDH GAPDH ACLY ACLY ALDH2 ALDH2 MDH2 MDH2 CFL1 CFL1 TUBB TUBB ATP5PD ATP5PD SUMO2 SUMO2 RAB35 RAB35 CS CS ALDH3A2 ALDH3A2 ATP5F1D ATP5F1D
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RAB7AUncharacterized protein. (207 aa)
FHFumarate hydratase. (514 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (575 aa)
OGDHOxoglutarate dehydrogenase. (1038 aa)
ACO2Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (780 aa)
ALDH7A1Aldehyde dehydrogenase 7 family member A1; Belongs to the aldehyde dehydrogenase family. (539 aa)
ENSCHIP00000004162Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (515 aa)
SUMO1Small ubiquitin-related modifier. (101 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (255 aa)
SUMO4Small ubiquitin-related modifier. (95 aa)
ATP5F1BATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (528 aa)
NOP10NOP10 ribonucleoprotein. (64 aa)
FAHFumarylacetoacetase. (419 aa)
ACTBUncharacterized protein. (375 aa)
ALDOAFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (416 aa)
LAMC1Laminin subunit gamma 1. (1608 aa)
PSMA7Proteasome subunit alpha type. (248 aa)
ATP5F1AATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (560 aa)
AARS1Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (968 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
SUMO3Small ubiquitin-related modifier. (104 aa)
ENO1Enolase 1. (434 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (531 aa)
ALDH4A1Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (576 aa)
PELOProtein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (386 aa)
CSTF2Cleavage stimulation factor subunit 2. (592 aa)
HYOU1Hypoxia up-regulated 1. (1033 aa)
SDHASuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (665 aa)
UCHL3Ubiquitin carboxyl-terminal hydrolase. (230 aa)
AARS2Alanyl-tRNA synthetase 2, mitochondrial; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (983 aa)
DERL1Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (251 aa)
NARS1Asparaginyl-tRNA synthetase. (559 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (464 aa)
ACAT1Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (409 aa)
CACYBPCalcyclin binding protein. (230 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
ACLYATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. (1101 aa)
ALDH2Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (524 aa)
MDH2Malate dehydrogenase. (338 aa)
CFL1Cofilin 1; Belongs to the actin-binding proteins ADF family. (165 aa)
TUBBTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (444 aa)
ATP5PDATP synthase subunit d, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...] (162 aa)
SUMO2Small ubiquitin-related modifier. (95 aa)
RAB35RAB35, member RAS oncogene family. (183 aa)
CSCitrate synthase; Belongs to the citrate synthase family. (454 aa)
ALDH3A2Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (500 aa)
ATP5F1DATP synthase F1 subunit delta. (168 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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