STRINGSTRING
LIG4 LIG4 RAD50 RAD50 APEX1 APEX1 TERT TERT RAD52 RAD52 NEIL3 NEIL3 MBD4 MBD4 MLH3 MLH3 ERCC6 ERCC6 TP53BP1 TP53BP1 AXIN1 AXIN1 XPA XPA CCND1 CCND1 ARID1A ARID1A ARID2 ARID2 MLH1 MLH1 KEAP1 KEAP1 H2AX H2AX XRCC6 XRCC6 EXO1 EXO1 ACTB ACTB PRKDC PRKDC MSH6 MSH6 TSC2 TSC2 WRN WRN DDB1 DDB1 KMT2D KMT2D TDG TDG PXDN PXDN ATM ATM APOB APOB PMS2 PMS2 LEP LEP XRCC3 XRCC3 MRE11 MRE11 MSH2 MSH2 XRCC5 XRCC5 RPS6KA3 RPS6KA3 GAPDH GAPDH RAD23B RAD23B OGG1 OGG1 CHEK2 CHEK2 MUS81 MUS81 TP53 TP53 CHEK1 CHEK1 NFE2L2 NFE2L2 FANCD2 FANCD2 MSH3 MSH3 BRCA1 BRCA1 RAD51 RAD51
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LIG4DNA ligase. (911 aa)
RAD50Zinc-hook domain-containing protein. (1332 aa)
APEX1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1123 aa)
RAD52RAD52 homolog, DNA repair protein. (416 aa)
NEIL3Nei like DNA glycosylase 3. (606 aa)
MBD4Methyl-CpG-binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. (554 aa)
MLH3MutL homolog 3. (1463 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1481 aa)
TP53BP1Tumor protein p53 binding protein 1. (1966 aa)
AXIN1Axin 1. (867 aa)
XPAXPA, DNA damage recognition and repair factor. (273 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
ARID1AAT-rich interaction domain 1A. (2285 aa)
ARID2AT-rich interaction domain 2. (1835 aa)
MLH1MutL homolog 1. (758 aa)
KEAP1Kelch like ECH associated protein 1. (624 aa)
H2AXHistone H2A; Belongs to the histone H2A family. (143 aa)
XRCC6X-ray repair cross complementing 6. (607 aa)
EXO1Exonuclease 1. (835 aa)
ACTBUncharacterized protein. (375 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4117 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1361 aa)
TSC2Rap-GAP domain-containing protein. (1817 aa)
WRNWRN RecQ like helicase. (1405 aa)
DDB1Damage specific DNA binding protein 1. (1140 aa)
KMT2DLysine methyltransferase 2D. (5491 aa)
TDGThymine DNA glycosylase. (403 aa)
PXDNPeroxidasin. (1525 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3058 aa)
APOBApolipoprotein B. (4620 aa)
PMS2PMS1 homolog 2, mismatch repair system component. (887 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (192 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (341 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (724 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (946 aa)
XRCC5X-ray repair cross complementing 5. (736 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
RAD23BRAD23 homolog B, nucleotide excision repair protein. (408 aa)
OGG18-oxoguanine DNA glycosylase. (345 aa)
CHEK2Checkpoint kinase 2. (534 aa)
MUS81MUS81 structure-specific endonuclease subunit. (552 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
CHEK1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
NFE2L2Nuclear factor erythroid 2-related factor 2. (616 aa)
FANCD2FA complementation group D2. (1423 aa)
MSH3DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1119 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1843 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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