STRINGSTRING
COL1A2 COL1A2 TNF TNF TET1 TET1 TGFB1 TGFB1 DNMT1 DNMT1 COL5A2 COL5A2 SP1 SP1 ACTB ACTB SMAD3 SMAD3 DNMT3A DNMT3A TDG TDG DCN DCN COL1A1 COL1A1 COL4A1 COL4A1 GAPDH GAPDH TGFB2 TGFB2 COL15A1 COL15A1 IL1B IL1B TGFB3 TGFB3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
COL1A2Collagen type I alpha 2 chain. (1128 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
TET1Tet methylcytosine dioxygenase 1. (2168 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1591 aa)
COL5A2Collagen type V alpha 2 chain. (1252 aa)
SP1Uncharacterized protein. (786 aa)
ACTBUncharacterized protein. (375 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
DNMT3ADNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (915 aa)
TDGThymine DNA glycosylase. (403 aa)
DCNDecorin; May affect the rate of fibrils formation. (360 aa)
COL1A1Collagen type I alpha 1 chain. (1463 aa)
COL4A1Collagen type IV alpha 1 chain. (1608 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
COL15A1Collagen type XV alpha 1 chain. (1375 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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