STRINGSTRING
MRGPRF MRGPRF SNAI2 SNAI2 NFATC4 NFATC4 COL16A1 COL16A1 ANTXR1 ANTXR1 PRDM1 PRDM1 EGR1 EGR1 MMP3 MMP3 TIMP3 TIMP3 FURIN FURIN COL4A1 COL4A1 FKBP10 FKBP10 VGLL3 VGLL3 FBN1 FBN1 COL1A1 COL1A1 NFATC1 NFATC1 SPARC SPARC ATF6B ATF6B TIMP4 TIMP4 COL6A2 COL6A2 ACTA2 ACTA2 THBS1 THBS1 KLF4 KLF4 LOX LOX EFEMP2 EFEMP2 RUNX1 RUNX1 E2F4 E2F4 PPARG PPARG TEAD1 TEAD1 PPIC PPIC FBN2 FBN2 TGFB1I1 TGFB1I1 SMAD6 SMAD6 FBN3 FBN3 TGFB1 TGFB1 ATOH8 ATOH8 PTGIS PTGIS ADAMTS18 ADAMTS18 INS INS CEBPD CEBPD PRRX1 PRRX1 PRSS23 PRSS23 LTBP2 LTBP2 POSTN POSTN CIZ1 CIZ1 BGN BGN CD248 CD248 SERPINH1 SERPINH1 MMP15 MMP15 TGFB3 TGFB3 COPZ2 COPZ2 PALLD PALLD COL4A2 COL4A2 COL1A2 COL1A2 CALU CALU TIMP2 TIMP2 LTBP1 LTBP1 PRRX2 PRRX2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MRGPRFMAS related GPR family member F; Belongs to the G-protein coupled receptor 1 family. (343 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
NFATC4Nuclear factor of activated T cells 4. (901 aa)
COL16A1Collagen type XVI alpha 1 chain. (1414 aa)
ANTXR1ANTXR cell adhesion molecule 1. (564 aa)
PRDM1PR/SET domain 1. (851 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
MMP3Matrix metallopeptidase 3. (477 aa)
TIMP3Tissue inhibitor of metalloproteinase 3 protein. (211 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (794 aa)
COL4A1Collagen type IV alpha 1 chain. (1608 aa)
FKBP10Peptidylprolyl isomerase. (574 aa)
VGLL3Vestigial like family member 3. (379 aa)
FBN1Fibrillin 1. (2860 aa)
COL1A1Collagen type I alpha 1 chain. (1463 aa)
NFATC1Nuclear factor of activated T cells 1. (1002 aa)
SPARCOsteonectin. (303 aa)
ATF6BActivating transcription factor 6 beta. (708 aa)
TIMP4TIMP metallopeptidase inhibitor 4. (224 aa)
COL6A2Collagen type VI alpha 2 chain. (1027 aa)
ACTA2Actin alpha 2, smooth muscle. (377 aa)
THBS1Thrombospondin 1. (1218 aa)
KLF4Kruppel like factor 4. (510 aa)
LOXLysyl oxidase. (418 aa)
EFEMP2EGF containing fibulin extracellular matrix protein 2. (443 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (453 aa)
E2F4E2F transcription factor 4. (405 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
TEAD1TEA domain transcription factor 1. (436 aa)
PPICPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (212 aa)
FBN2Fibrillin 2. (2900 aa)
TGFB1I1Transforming growth factor beta 1 induced transcript 1. (415 aa)
SMAD6Mothers against decapentaplegic homolog. (497 aa)
FBN3Fibrillin 3. (2792 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ATOH8Atonal bHLH transcription factor 8. (315 aa)
PTGISProstacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (503 aa)
ADAMTS18ADAM metallopeptidase with thrombospondin type 1 motif 18. (1223 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
CEBPDCCAAT/enhancer-binding protein. (256 aa)
PRRX1Paired related homeobox 1. (245 aa)
PRSS23Serine protease 23. (375 aa)
LTBP2Latent transforming growth factor beta binding protein 2. (1842 aa)
POSTNPeriostin. (836 aa)
CIZ1CDKN1A interacting zinc finger protein 1. (842 aa)
BGNBiglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (373 aa)
CD248CD248 molecule. (773 aa)
SERPINH1Serpin family H member 1; Belongs to the serpin family. (418 aa)
MMP15Matrix metallopeptidase 15. (675 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
COPZ2Coatomer subunit zeta; The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. (212 aa)
PALLDPalladin, cytoskeletal associated protein. (1345 aa)
COL4A2Collagen type IV alpha 2 chain. (1607 aa)
COL1A2Collagen type I alpha 2 chain. (1128 aa)
CALUCalumenin. (315 aa)
TIMP2TIMP metallopeptidase inhibitor 2. (220 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1491 aa)
PRRX2Paired related homeobox 2. (254 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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