STRINGSTRING
TP53 TP53 GRPEL1 GRPEL1 SLC25A3 SLC25A3 MSTO1 MSTO1 NDUFB6 NDUFB6 AIFM1 AIFM1 SDHD SDHD TIMM50 TIMM50 NEFH NEFH SLC25A19 SLC25A19 NDUFS7 NDUFS7 ENSCHIP00000004646 ENSCHIP00000004646 B2M B2M LOC108638252 LOC108638252 SDHC SDHC TIMM8B TIMM8B HSF1 HSF1 SLC25A37 SLC25A37 SOD2 SOD2 SLC25A20 SLC25A20 TIMM17A TIMM17A UCP1 UCP1 NEFL NEFL ATP5PB ATP5PB RELB RELB SDHB SDHB ACTB ACTB ATP5ME ATP5ME SLC25A22 SLC25A22 TIMM17B TIMM17B BID BID SLC25A1 SLC25A1 NDUFV2 NDUFV2 HPRT1 HPRT1 RHOT1 RHOT1 TIMM22 TIMM22 NDUFC1 NDUFC1 BAK1 BAK1 NDUFS5 NDUFS5 UCP2 UCP2 ATP5MC1 ATP5MC1 RHOT2 RHOT2 UQCRQ UQCRQ SDHA SDHA CASP2 CASP2 ATP5MC3 ATP5MC3 RBM5 RBM5 LOC102168547 LOC102168547 NEFM NEFM TIMM10B TIMM10B UCP3 UCP3 AR AR SLC25A25 SLC25A25 HSP90AA1 HSP90AA1 SLC25A13 SLC25A13 GAPDH GAPDH NDUFA8 NDUFA8 DNM1L DNM1L BCL2L1 BCL2L1 NFE2L2 NFE2L2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
GRPEL1GrpE protein homolog; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the GrpE family. (217 aa)
SLC25A3Solute carrier family 25 member 3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (362 aa)
MSTO1Misato mitochondrial distribution and morphology regulator 1. (572 aa)
NDUFB6NADH:ubiquinone oxidoreductase subunit B6. (128 aa)
AIFM1Apoptosis inducing factor mitochondria associated 1. (613 aa)
SDHDSuccinate dehydrogenase [ubiquinone] cytochrome b small subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (159 aa)
TIMM50Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. (355 aa)
NEFHIF rod domain-containing protein; Belongs to the intermediate filament family. (1049 aa)
SLC25A19Solute carrier family 25 member 19; Belongs to the mitochondrial carrier (TC 2.A.29) family. (318 aa)
NDUFS7NADH:ubiquinone oxidoreductase core subunit S7; Belongs to the complex I 20 kDa subunit family. (238 aa)
ENSCHIP00000004646Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (118 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (124 aa)
LOC108638252ATP synthase subunit; Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proto [...] (103 aa)
SDHCSuccinate dehydrogenase complex subunit C. (169 aa)
TIMM8BTranslocase of inner mitochondrial membrane 8 homolog B; Belongs to the small Tim family. (83 aa)
HSF1HSF_DOMAIN domain-containing protein. (537 aa)
SLC25A37Solute carrier family 25 member 37; Belongs to the mitochondrial carrier (TC 2.A.29) family. (338 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
SLC25A20Solute carrier family 25 member 20; Belongs to the mitochondrial carrier (TC 2.A.29) family. (301 aa)
TIMM17AMitochondrial import inner membrane translocase subunit TIM17; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. (171 aa)
UCP1Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (305 aa)
NEFLNeurofilament light; Belongs to the intermediate filament family. (554 aa)
ATP5PBATP synthase peripheral stalk-membrane subunit b. (256 aa)
RELBRELB proto-oncogene, NF-kB subunit. (645 aa)
SDHBSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (280 aa)
ACTBUncharacterized protein. (375 aa)
ATP5MEUncharacterized protein. (71 aa)
SLC25A22Solute carrier family 25 member 22; Belongs to the mitochondrial carrier (TC 2.A.29) family. (322 aa)
TIMM17BMitochondrial import inner membrane translocase subunit TIM17; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. (172 aa)
BIDUncharacterized protein. (244 aa)
SLC25A1Solute carrier family 25 member 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (311 aa)
NDUFV2NADH:ubiquinone oxidoreductase core subunit V2. (249 aa)
HPRT1Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (218 aa)
RHOT1Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. (704 aa)
TIMM22Translocase of inner mitochondrial membrane 22. (194 aa)
NDUFC1Uncharacterized protein. (76 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
NDUFS5NADH:ubiquinone oxidoreductase subunit S5. (106 aa)
UCP2Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
ATP5MC1ATP-synt_C domain-containing protein; Belongs to the ATPase C chain family. (136 aa)
RHOT2Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. (594 aa)
UQCRQUbiquinol-cytochrome c reductase complex III subunit VII. (82 aa)
SDHASuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (665 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (456 aa)
ATP5MC3ATP-synt_C domain-containing protein; Belongs to the ATPase C chain family. (141 aa)
RBM5RNA binding motif protein 5. (815 aa)
LOC102168547Beta-2-microglobulin. (124 aa)
NEFMNeurofilament medium; Belongs to the intermediate filament family. (922 aa)
TIMM10Bzf-Tim10_DDP domain-containing protein. (116 aa)
UCP3Uncoupling protein 3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (311 aa)
ARAndrogen receptor. (891 aa)
SLC25A25Solute carrier family 25 member 25; Belongs to the mitochondrial carrier (TC 2.A.29) family. (501 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (733 aa)
SLC25A13Solute carrier family 25 member 13; Belongs to the mitochondrial carrier (TC 2.A.29) family. (666 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
NDUFA8NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (175 aa)
DNM1LDynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (707 aa)
BCL2L1BH4_2 domain-containing protein. (233 aa)
NFE2L2Nuclear factor erythroid 2-related factor 2. (616 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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