STRINGSTRING
PPARA PPARA NNAT NNAT MEST MEST ACADVL ACADVL HADHB HADHB ACAA2 ACAA2 RXRA RXRA CIDEA CIDEA EBF2 EBF2 SLC7A10 SLC7A10 ANGPTL4 ANGPTL4 ANGPTL2 ANGPTL2 ETFDH ETFDH HADHA HADHA PPIA PPIA LIPE LIPE ELOVL3 ELOVL3 PLIN5 PLIN5 LEP LEP FASN FASN PRDM16 PRDM16 SLC27A2 SLC27A2 PXDN PXDN PPARGC1A PPARGC1A PPARG PPARG TBX15 TBX15 DIO2 DIO2 FABP3 FABP3 PPARD PPARD ADRB3 ADRB3 DECR1 DECR1 SLC36A2 SLC36A2 LOC102190925 LOC102190925 TRIM28 TRIM28 UCP1 UCP1 EHHADH EHHADH FABP4 FABP4 IRS2 IRS2 TMEM26 TMEM26
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPARAPeroxisome proliferator activated receptor alpha. (470 aa)
NNATNeuronatin. (81 aa)
MESTMesoderm specific transcript. (335 aa)
ACADVLAcyl-CoA dehydrogenase very long chain. (655 aa)
HADHBHydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta; Belongs to the thiolase-like superfamily. Thiolase family. (475 aa)
ACAA2Acetyl-CoA acyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (398 aa)
RXRANR LBD domain-containing protein. (106 aa)
CIDEACIDE-N domain-containing protein. (219 aa)
EBF2EBF transcription factor 2. (575 aa)
SLC7A10Solute carrier family 7 member 10. (528 aa)
ANGPTL4Angiopoietin like 4. (413 aa)
ANGPTL2Angiopoietin like 2. (493 aa)
ETFDHElectron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (617 aa)
HADHAHydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha; Belongs to the enoyl-CoA hydratase/isomerase family. (763 aa)
PPIAPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (164 aa)
LIPELipase E, hormone sensitive type. (756 aa)
ELOVL3Elongation of very long chain fatty acids protein 3; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precurs [...] (270 aa)
PLIN5Perilipin; Belongs to the perilipin family. (456 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (192 aa)
FASNFatty acid synthase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. (2755 aa)
PRDM16PR/SET domain 16. (1271 aa)
SLC27A2Solute carrier family 27 member 2. (620 aa)
PXDNPeroxidasin. (1525 aa)
PPARGC1ARRM domain-containing protein. (797 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
TBX15T-box transcription factor 15. (602 aa)
DIO2Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine). (222 aa)
FABP3Heart-type fatty acid binding protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (133 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
ADRB3Beta-3 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta- 3 is involved in the regulation of lipolysis and thermogenesis. (430 aa)
DECR12,4-dienoyl-CoA reductase 1. (329 aa)
SLC36A2Solute carrier family 36 member 2. (482 aa)
LOC102190925Uncharacterized protein. (419 aa)
TRIM28Tripartite motif containing 28. (837 aa)
UCP1Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (305 aa)
EHHADHEnoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase. (723 aa)
FABP4Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
IRS2Insulin receptor substrate 2. (1465 aa)
TMEM26Transmembrane protein 26. (368 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.