14 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RAD52	RAD52 homolog, DNA repair protein. (416 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
	BRCA2	BRCA2 DNA repair associated. (3405 aa)
	ALB	Serum albumin. (608 aa)
	KLF4	Kruppel like factor 4. (510 aa)
	ZEB1	Zinc finger E-box binding homeobox 1. (1127 aa)
	EME1	Essential meiotic structure-specific endonuclease 1. (580 aa)
	PXDN	Peroxidasin. (1525 aa)
	WRN	WRN RecQ like helicase. (1405 aa)
	GEN1	GEN1 Holliday junction 5' flap endonuclease. (931 aa)
	ACTB	Uncharacterized protein. (375 aa)
	KLF5	Uncharacterized protein. (454 aa)
	RECQL4	RecQ like helicase 4. (1176 aa)
	RECQL5	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (991 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ALB	ENSCHIP00000011080	ENSCHIP00000020234	Uncharacterized protein.	Serum albumin.	0.961
ACTB	BRCA2	ENSCHIP00000011080	ENSCHIP00000024039	Uncharacterized protein.	BRCA2 DNA repair associated.	0.617
ACTB	KLF4	ENSCHIP00000011080	ENSCHIP00000017278	Uncharacterized protein.	Kruppel like factor 4.	0.761
ACTB	KLF5	ENSCHIP00000011080	ENSCHIP00000010022	Uncharacterized protein.	Uncharacterized protein.	0.460
ACTB	PXDN	ENSCHIP00000011080	ENSCHIP00000015493	Uncharacterized protein.	Peroxidasin.	0.962
ACTB	RAD52	ENSCHIP00000011080	ENSCHIP00000004740	Uncharacterized protein.	RAD52 homolog, DNA repair protein.	0.410
ACTB	TP53	ENSCHIP00000011080	ENSCHIP00000030141	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.907
ACTB	ZEB1	ENSCHIP00000011080	ENSCHIP00000015942	Uncharacterized protein.	Zinc finger E-box binding homeobox 1.	0.778
ALB	ACTB	ENSCHIP00000020234	ENSCHIP00000011080	Serum albumin.	Uncharacterized protein.	0.961
ALB	BRCA2	ENSCHIP00000020234	ENSCHIP00000024039	Serum albumin.	BRCA2 DNA repair associated.	0.503
ALB	KLF4	ENSCHIP00000020234	ENSCHIP00000017278	Serum albumin.	Kruppel like factor 4.	0.673
ALB	PXDN	ENSCHIP00000020234	ENSCHIP00000015493	Serum albumin.	Peroxidasin.	0.988
ALB	TP53	ENSCHIP00000020234	ENSCHIP00000030141	Serum albumin.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.844
ALB	ZEB1	ENSCHIP00000020234	ENSCHIP00000015942	Serum albumin.	Zinc finger E-box binding homeobox 1.	0.592
BRCA2	ACTB	ENSCHIP00000024039	ENSCHIP00000011080	BRCA2 DNA repair associated.	Uncharacterized protein.	0.617
BRCA2	ALB	ENSCHIP00000024039	ENSCHIP00000020234	BRCA2 DNA repair associated.	Serum albumin.	0.503
BRCA2	EME1	ENSCHIP00000024039	ENSCHIP00000015587	BRCA2 DNA repair associated.	Essential meiotic structure-specific endonuclease 1.	0.706
BRCA2	GEN1	ENSCHIP00000024039	ENSCHIP00000011906	BRCA2 DNA repair associated.	GEN1 Holliday junction 5' flap endonuclease.	0.697
BRCA2	PXDN	ENSCHIP00000024039	ENSCHIP00000015493	BRCA2 DNA repair associated.	Peroxidasin.	0.511
BRCA2	RAD52	ENSCHIP00000024039	ENSCHIP00000004740	BRCA2 DNA repair associated.	RAD52 homolog, DNA repair protein.	0.907